HOXD11: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-D11''' is a [[protein]] that in humans is encoded by the ''HOXD11'' [[gene]].<ref name="pmid1973146">{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=August 1990| pmid = 1973146 | pmc =  | doi =10.1016/0888-7543(90)90186-X  }}</ref><ref name="pmid1358459">{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=December 1992| pmid = 1358459 | pmc = | doi =10.1016/0092-8674(92)90588-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXD11 homeobox D11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3237| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in [[morphogenesis]] in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.<ref name="entrez"/>
{{GNF_Protein_box
<ref name="pmid7925020">{{cite journal |vauthors=Davis AP, Capecchi MR | title = Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11 | journal = Development | volume = 120 | issue = 8 | pages = 2187–98 | date=1 August 1994| pmid = 7925020 | url = http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=7925020 }}</ref><ref name="pmid7596412">{{cite journal |vauthors=Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR | title = Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11 | journal = Nature | volume = 375 | issue = 6534 | pages = 791–5 |date=June 1995 | pmid = 7596412 | doi = 10.1038/375791a0 | url = }}</ref><ref name="pmid8620844">{{cite journal |vauthors=Davis AP, Capecchi MR | title = A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse | journal = Development | volume = 122 | issue = 4 | pages = 1175–85 | date=1 April 1996| pmid = 8620844 | url = http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=8620844 }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Homeobox D11
| HGNCid = 5134
| Symbol = HOXD11
| AltSymbols =; HOX4; HOX4F
| OMIM = 142986
| ECnumber = 
| Homologene = 7368
| MGIid = 96203
| GeneAtlas_image1 = PBB_GE_HOXD11_214604_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3237
    | Hs_Ensembl = ENSG00000128713
    | Hs_RefseqProtein = NP_067015
    | Hs_RefseqmRNA = NM_021192
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 176680330
    | Hs_GenLoc_end = 176682562
    | Hs_Uniprot = P31277
    | Mm_EntrezGene = 15431
    | Mm_Ensembl = ENSMUSG00000042499
    | Mm_RefseqmRNA = NM_008273
    | Mm_RefseqProtein = NP_032299
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 74482838
    | Mm_GenLoc_end = 74487855
    | Mm_Uniprot = P23813
  }}
}}
'''Homeobox D11''', also known as '''HOXD11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD11 homeobox D11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3237| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD11 homeobox D11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3237| accessdate = }}</ref><ref>Davis AP, Capecchi MR.'''Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11.''' ''Development.'' 1994 Aug;120(8):2187-98.  [http://www.ncbi.nlm.nih.gov/pubmed/7925020 PMID:7925020]</ref><ref>Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR.'''Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.''' ''Nature.'' 1995 Jun 29;375(6534):791-5.  [http://www.ncbi.nlm.nih.gov/pubmed/7596412 PMID:7596412]</ref><ref>Davis AP, Capecchi MR.'''A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.''' ''Development.'' 1996 Apr;122(4):1175-85.  [http://www.ncbi.nlm.nih.gov/pubmed/8620844 PMID:8620844]</ref>
}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{Reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Johnson RL, Tabin CJ |title=Molecular models for vertebrate limb development. |journal=Cell |volume=90 |issue= 6 |pages= 979-90 |year= 1997 |pmid= 9323126 |doi=  }}
*{{cite journal  |vauthors=Johnson RL, Tabin CJ |title=Molecular models for vertebrate limb development |journal=Cell |volume=90 |issue= 6 |pages= 979–90 |year= 1997 |pmid= 9323126 |doi=10.1016/S0092-8674(00)80364-5 }}
*{{cite journal  | author=Goodman FR |title=Limb malformations and the human HOX genes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256-65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776 }}
*{{cite journal  | author=Goodman FR |title=Limb malformations and the human HOX genes |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256–65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776 }}
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
*{{cite journal   |vauthors=Acampora D, D'Esposito M, Faiella A, etal |title=The human HOX gene family |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=10.1093/nar/17.24.10385  | pmc=335308 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
*{{cite journal   |vauthors=Shen WF, Montgomery JC, Rozenfeld S, etal |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448–58 |year= 1997 |pmid= 9343407 |doi= | pmc=232497 }}
*{{cite journal  | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
*{{cite journal  |vauthors=Hérault Y, Beckers J, Gérard M, Duboule D |title=Hox gene expression in limbs: colinearity by opposite regulatory controls |journal=Dev. Biol. |volume=208 |issue= 1 |pages= 157–65 |year= 1999 |pmid= 10075849 |doi= 10.1006/dbio.1998.9179 }}
*{{cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, ''et al.'' |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448-58 |year= 1997 |pmid= 9343407 |doi=  }}
*{{cite journal   |vauthors=Del Campo M, Jones MC, Veraksa AN, etal |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=10.1086/302467  | pmc=1378080 }}
*{{cite journal  | author=Hérault Y, Beckers J, Gérard M, Duboule D |title=Hox gene expression in limbs: colinearity by opposite regulatory controls. |journal=Dev. Biol. |volume=208 |issue= 1 |pages= 157-65 |year= 1999 |pmid= 10075849 |doi= 10.1006/dbio.1998.9179 }}
*{{cite journal  |vauthors=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1 |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1–2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=10.1159/000015651 }}
*{{cite journal | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi=  }}
*{{cite journal  |vauthors=Patterson LT, Pembaur M, Potter SS |title=Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney |journal=Development |volume=128 |issue= 11 |pages= 2153–61 |year= 2001 |pmid= 11493536 |doi=  }}
*{{cite journal  | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi=  }}
*{{cite journal  |vauthors=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb Microdeletion Removing HOXD9–HOXD13 and EVX2 Causes Synpolydactyly |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547–55 |year= 2002 |pmid= 11778160 |doi=10.1086/338921  | pmc=384929 }}
*{{cite journal  | author=Patterson LT, Pembaur M, Potter SS |title=Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. |journal=Development |volume=128 |issue= 11 |pages= 2153-61 |year= 2001 |pmid= 11493536 |doi=  }}
*{{cite journal   |vauthors=Taketani T, Taki T, Shibuya N, etal |title=The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15) |journal=Cancer Res. |volume=62 |issue= 1 |pages= 33–7 |year= 2002 |pmid= 11782354 |doi=  }}
*{{cite journal  | author=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547-55 |year= 2002 |pmid= 11778160 |doi=  }}
*{{cite journal   |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Taketani T, Taki T, Shibuya N, ''et al.'' |title=The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15). |journal=Cancer Res. |volume=62 |issue= 1 |pages= 33-7 |year= 2002 |pmid= 11782354 |doi=  }}
*{{cite journal  |vauthors=Boulet AM, Capecchi MR |title=Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse |journal=Dev. Biol. |volume=249 |issue= 1 |pages= 96–107 |year= 2002 |pmid= 12217321 |doi=10.1006/dbio.2002.0755 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Boulet AM, Capecchi MR |title=Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. |journal=Dev. Biol. |volume=249 |issue= 1 |pages= 96-107 |year= 2002 |pmid= 12217321 |doi=  }}
*{{cite journal   |vauthors=Zhao X, Sun M, Zhao J, etal |title=Mutations in HOXD13 Underlie Syndactyly Type V and a Novel Brachydactyly-Syndactyly Syndrome |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 361–71 |year= 2007 |pmid= 17236141 |doi= 10.1086/511387 | pmc=1785357 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Zhao X, Sun M, Zhao J, ''et al.'' |title=Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 361-71 |year= 2007 |pmid= 17236141 |doi= 10.1086/511387 }}
}}
}}
{{refend}}
{{Refend}}


== External links ==
== External links ==
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{{NLM content}}
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{{Transcription factors}}
{{Transcription factors|g3}}
 
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Latest revision as of 14:01, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.[3] [4][5][6]

See also

References

  1. ↑ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXD11 homeobox D11".
  4. ↑ Davis AP, Capecchi MR (1 August 1994). "Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11". Development. 120 (8): 2187–98. PMID 7925020.
  5. ↑ Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR (June 1995). "Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11". Nature. 375 (6534): 791–5. doi:10.1038/375791a0. PMID 7596412.
  6. ↑ Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development. 122 (4): 1175–85. PMID 8620844.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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