HOXC4: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-C4''' is a [[protein]] that in humans is encoded by the ''HOXC4'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460  | date = Aug 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3  | date = Dec 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXC4 homeobox C4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3221| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox C4
| HGNCid = 5126
| Symbol = HOXC4
| AltSymbols =; HOX3; HOX3E; cp19
| OMIM = 142974
| ECnumber = 
| Homologene = 8408
| MGIid = 96195
| GeneAtlas_image1 = PBB_GE_HOXC4_206194_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3221
    | Hs_Ensembl = ENSG00000198353
    | Hs_RefseqProtein = NP_055435
    | Hs_RefseqmRNA = NM_014620
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 52733928
    | Hs_GenLoc_end = 52736080
    | Hs_Uniprot = P09017
    | Mm_EntrezGene = 15423
    | Mm_Ensembl = ENSMUSG00000075394
    | Mm_RefseqmRNA = NM_013553
    | Mm_RefseqProtein = NP_038581
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 102862757
    | Mm_GenLoc_end = 102864026
    | Mm_Uniprot = Q08624
  }}
}}
'''Homeobox C4''', also known as '''HOXC4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXC4 homeobox C4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3221| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.<ref name="entrez">{{cite web | title = Entrez Gene: HOXC4 homeobox C4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3221| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
HOXC4 has been shown to [[Protein-protein interaction|interact]] with [[Ku70]].<ref name=pmid11279128>{{cite journal | vauthors = Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ | title = The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 16848–56  | date = May 2001 | pmid = 11279128 | doi = 10.1074/jbc.M100768200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
| citations =
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi= }}
* {{cite journal | vauthors = Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH | title = Cognate homeo-box loci mapped on homologous human and mouse chromosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 83 | issue = 23 | pages = 9104–8 | year = 1986 | pmid = 2878432 | pmc = 387083 | doi = 10.1073/pnas.83.23.9104 }}
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi= }}
* {{cite journal | vauthors = Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E | title = At least three human homeoboxes on chromosome 12 belong to the same transcription unit | journal = Nucleic Acids Res. | volume = 16 | issue = 12 | pages = 5379–90 | year = 1988 | pmid = 2898768 | pmc = 336773 | doi = 10.1093/nar/16.12.5379 }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | year = 1995 | pmid = 7566098 | doi = | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Meazza R, Faiella A, Corsetti MT, Airoldi I, Ferrini S, Boncinelli E, Corte G | title = Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes | journal = Blood | volume = 85 | issue = 8 | pages = 2084–90 | year = 1995 | pmid = 7718879 | doi =  }}
*{{cite journal | author=Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH |title=Cognate homeo-box loci mapped on homologous human and mouse chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9104-8 |year= 1987 |pmid= 2878432 |doi= }}
* {{cite journal | vauthors = Rieger E, Bijl JJ, van Oostveen JW, Soyer HP, Oudejans CB, Jiwa NM, Walboomers JM, Meijer CJ | title = Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation | journal = J. Invest. Dermatol. | volume = 103 | issue = 3 | pages = 341–6 | year = 1994 | pmid = 7915745 | doi = 10.1111/1523-1747.ep12394888 }}
*{{cite journal | author=Simeone A, Pannese M, Acampora D, ''et al.'' |title=At least three human homeoboxes on chromosome 12 belong to the same transcription unit. |journal=Nucleic Acids Res. |volume=16 |issue= 12 |pages= 5379-90 |year= 1988 |pmid= 2898768 |doi=  }}
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1–2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
* {{cite journal | vauthors = Bijl JJ, Rieger E, van Oostveen JW, Walboomers JM, Kreike M, Willemze R, Meijer CJ | title = HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas | journal = Am. J. Pathol. | volume = 151 | issue = 4 | pages = 1067–74 | year = 1997 | pmid = 9327740 | pmc = 1858029 | doi =  }}
*{{cite journal | author=Meazza R, Faiella A, Corsetti MT, ''et al.'' |title=Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes. |journal=Blood |volume=85 |issue= 8 |pages= 2084-90 |year= 1995 |pmid= 7718879 |doi= }}
* {{cite journal | vauthors = Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ | title = The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 16848–56 | year = 2001 | pmid = 11279128 | doi = 10.1074/jbc.M100768200 }}
*{{cite journal | author=Rieger E, Bijl JJ, van Oostveen JW, ''et al.'' |title=Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation. |journal=J. Invest. Dermatol. |volume=103 |issue= 3 |pages= 341-6 |year= 1994 |pmid= 7915745 |doi=  }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | year = 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P | title = Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 23141–50 | year = 2003 | pmid = 12672812 | doi = 10.1074/jbc.M212952200 }}
*{{cite journal | author=Bijl JJ, Rieger E, van Oostveen JW, ''et al.'' |title=HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. |journal=Am. J. Pathol. |volume=151 |issue= 4 |pages= 1067-74 |year= 1997 |pmid= 9327740 |doi= }}
* {{cite journal | vauthors = Kim EC, Edmonston CR, Wu X, Schaffer A, Casali P | title = The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination | journal = J. Biol. Chem. | volume = 279 | issue = 40 | pages = 42258–69 | year = 2004 | pmid = 15252056 | pmc = 4631311 | doi = 10.1074/jbc.M407496200 }}
*{{cite journal | author=Schild-Poulter C, Pope L, Giffin W, ''et al.'' |title=The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 16848-56 |year= 2001 |pmid= 11279128 |doi= 10.1074/jbc.M100768200 }}
* {{cite journal | vauthors = Speleman F, Cauwelier B, Dastugue N, Cools J, Verhasselt B, Poppe B, Van Roy N, Vandesompele J, Graux C, Uyttebroeck A, Boogaerts M, De Moerloose B, Benoit Y, Selleslag D, Billiet J, Robert A, Huguet F, Vandenberghe P, De Paepe A, Marynen P, Hagemeijer A | title = A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias | journal = Leukemia | volume = 19 | issue = 3 | pages = 358–66 | year = 2005 | pmid = 15674412 | doi = 10.1038/sj.leu.2403657 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M | title = The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors | journal = Nucleic Acids Res. | volume = 34 | issue = 6 | pages = 1735–44 | year = 2006 | pmid = 16582099 | pmc = 1421504 | doi = 10.1093/nar/gkl105 }}
*{{cite journal | author=Schaffer A, Kim EC, Wu X, ''et al.'' |title=Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 23141-50 |year= 2003 |pmid= 12672812 |doi= 10.1074/jbc.M212952200 }}
*{{cite journal | author=Kim EC, Edmonston CR, Wu X, ''et al.'' |title=The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 42258-69 |year= 2004 |pmid= 15252056 |doi= 10.1074/jbc.M407496200 }}
*{{cite journal  | author=Speleman F, Cauwelier B, Dastugue N, ''et al.'' |title=A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. |journal=Leukemia |volume=19 |issue= 3 |pages= 358-66 |year= 2005 |pmid= 15674412 |doi= 10.1038/sj.leu.2403657 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Wissmüller S, Kosian T, Wolf M, ''et al.'' |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735-44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105 }}
}}
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{{Transcription factors}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-12-stub}}

Latest revision as of 14:01, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.[3]

See also

Interactions

HOXC4 has been shown to interact with Ku70.[4]

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXC4 homeobox C4".
  4. ↑ Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ (May 2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. 276 (20): 16848–56. doi:10.1074/jbc.M100768200. PMID 11279128.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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