HOXB3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-B3''' is a [[protein]] that in humans is encoded by the ''HOXB3'' [[gene]].<ref name="pmid1973146">{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc =  | doi =10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc =  | doi =10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB3 homeobox B3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3213| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Homeobox B3
| HGNCid = 5114
| Symbol = HOXB3
| AltSymbols =; HOX2; HOX2G; Hox-2.7
| OMIM = 142966
| ECnumber =
| Homologene = 1617
| MGIid = 96184
  | GeneAtlas_image1 = PBB_GE_HOXB3_208414_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3213
    | Hs_Ensembl = ENSG00000120093
    | Hs_RefseqProtein = NP_002137
    | Hs_RefseqmRNA = NM_002146
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43982246
    | Hs_GenLoc_end = 44006848
    | Hs_Uniprot = P14651
    | Mm_EntrezGene = 15410
    | Mm_Ensembl = ENSMUSG00000048763
    | Mm_RefseqmRNA = NM_001079869
    | Mm_RefseqProtein = NP_001073338
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96157147
    | Mm_GenLoc_end = 96162597
    | Mm_Uniprot = P09026
  }}
}}
'''Homeobox B3''', also known as '''HOXB3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXB3 homeobox B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3213| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).<ref name="entrez">{{cite web | title = Entrez Gene: HOXB3 homeobox B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3213| accessdate = }}</ref>
| summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).<ref name="entrez" />
}}
}}


==See also==
==See also==
* [[Homeobox]]
*[[Homeobox]]


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi= }}
*{{cite journal  | author=Giampaolo A |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=10.1111/j.1432-0436.1989.tb00598.x |name-list-format=vanc| author2=Acampora D  | author3=Zappavigna V  | display-authors=3  | last4=Pannese  | first4=Maria  | last5=d'Esposito  | first5=Maurizio  | last6=Care  | first6=Alessandra  | last7=Feiella  | first7=Antonio  | last8=Stornaiuolo  | first8=Anna  | last9=Russo  | first9=Giovanni }}
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
*{{cite journal  | author=Acampora D |title=The human HOX gene family |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=10.1093/nar/17.24.10385  | pmc=335308 |name-list-format=vanc| author2=D'Esposito M | author3=Faiella A | display-authors=3  | last4=Pannese  | first4=Maria  | last5=Migliaccio  | first5=Enrica  | last6=Morelli  | first6=Franco  | last7=Stornaiuolo  | first7=Anna  | last8=Nigro | first8=Vincenzo  | last9=Simeone  | first9=Antonio  }}
*{{cite journal  | author=Giampaolo A, Acampora D, Zappavigna V, ''et al.'' |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191-7 |year= 1989 |pmid= 2570724 |doi= }}
*{{cite journal  | author=Boncinelli E |title=Organization of human class I homeobox genes |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=  10.1139/g89-133|name-list-format=vanc| author2=Acampora D | author3=Pannese M  | display-authors=3  | last4=d'Esposito  | first4=M  | last5=Somma  | first5=R  | last6=Gaudino  | first6=G  | last7=Stornaiuolo  | first7=A  | last8=Cafiero  | first8=M  | last9=Faiella  | first9=A }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
*{{cite journal  | author=Guazzi S |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=  | pmc=395231 |name-list-format=vanc| author2=Lonigro R  | author3=Pintonello L  | display-authors=3  | last4=Boncinelli  | first4=E | last5=Di Lauro  | first5=R  | last6=Mavilio  | first6=F }}
*{{cite journal  | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi=  }}
*{{cite journal  | author=Apiou F |title=Fine mapping of human HOX gene clusters |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1–2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=10.1159/000134320 |name-list-format=vanc| author2=Flagiello D  | author3=Cillo C  | display-authors=3  | last4=Malfoy  | first4=B.  | last5=Poupon  | first5=M.-F.  | last6=Dutrillaux  | first6=B. }}
*{{cite journal | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
*{{cite journal  |vauthors=Bingle CD, Gowan S |title=Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter |journal=Biochem. J. |volume=319 ( Pt 3) |issue= Pt 3|pages= 669–74 |year= 1996 |pmid= 8920965 |doi= | pmc=1217841 }}
*{{cite journal  | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi=  }}
*{{cite journal  | author=Sauvageau G |title=Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation |journal=Immunity |volume=6 |issue= 1 |pages= 13–22 |year= 1997 |pmid= 9052833 |doi=10.1016/S1074-7613(00)80238-1 |name-list-format=vanc| author2=Thorsteinsdottir U  | author3=Hough MR  | display-authors=3  | last4=Hugo  | first4=Patrice  | last5=Lawrence  | first5=H.Jeffrey  | last6=Largman  | first6=Corey  | last7=Humphries  | first7=R.Keith }}
*{{cite journal | author=Bingle CD, Gowan S |title=Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter. |journal=Biochem. J. |volume=319 ( Pt 3) |issue=  |pages= 669-74 |year= 1996 |pmid= 8920965 |doi=  }}
*{{cite journal  |vauthors=Guazzi S, Pintonello ML, Viganò A, Boncinelli E |title=Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11092–9 |year= 1998 |pmid= 9556594 |doi=10.1074/jbc.273.18.11092  }}
*{{cite journal  | author=Sauvageau G, Thorsteinsdottir U, Hough MR, ''et al.'' |title=Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. |journal=Immunity |volume=6 |issue= 1 |pages= 13-22 |year= 1997 |pmid= 9052833 |doi= }}
*{{cite journal  |vauthors=Viganò MA, Di Rocco G, Zappavigna V, Mavilio F |title=Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6201–12 |year= 1998 |pmid= 9774637 |doi= | pmc=109207 }}
*{{cite journal | author=Guazzi S, Pintonello ML, Viganò A, Boncinelli E |title=Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11092-9 |year= 1998 |pmid= 9556594 |doi=  }}
*{{cite journal  | author=Kosaki K |title=Complete mutation analysis panel of the 39 human HOX genes |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 |name-list-format=vanc| author2=Kosaki R | author3=Suzuki T  | display-authors=3  | last4=Yoshihashi  | first4=Hiroshi  | last5=Takahashi  | first5=Takao  | last6=Sasaki  | first6=Katsumi  | last7=Tomita  | first7=Masaru  | last8=McGinnis  | first8=William  | last9=Matsuo  | first9=Nobutake }}
*{{cite journal  | author=Viganò MA, Di Rocco G, Zappavigna V, Mavilio F |title=Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6201-12 |year= 1998 |pmid= 9774637 |doi=  }}
*{{cite journal  |vauthors=Nakamura N, Yoshimi T, Miura T |title=Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3 |journal=Cell Growth Differ. |volume=13 |issue= 4 |pages= 195–203 |year= 2002 |pmid= 11971819 |doi= }}
*{{cite journal  | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Nakamura N, Yoshimi T, Miura T |title=Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3. |journal=Cell Growth Differ. |volume=13 |issue= 4 |pages= 195-203 |year= 2002 |pmid= 11971819 |doi=  }}
*{{cite journal  |vauthors=Pineault N, Abramovich C, Ohta H, Humphries RK |title=Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1 |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1907–17 |year= 2004 |pmid= 14966272 |doi=10.1128/MCB.24.5.1907-1917.2004  | pmc=350554  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Roche J |title=Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics |journal=Leukemia |volume=18 |issue= 6 |pages= 1059–63 |year= 2004 |pmid= 15085154 |doi= 10.1038/sj.leu.2403366  |name-list-format=vanc| author2=Zeng C  | author3=Barón A  | display-authors=3  | last4=Gadgil  | first4=S  | last5=Gemmill  | first5=R M  | last6=Tigaud  | first6=I  | last7=Thomas  | first7=X  | last8=Drabkin  | first8=H A }}
*{{cite journal  | author=Pineault N, Abramovich C, Ohta H, Humphries RK |title=Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1907-17 |year= 2004 |pmid= 14966272 |doi=  }}
*{{cite journal  | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971  |name-list-format=vanc| author2=Wei H  | author3=Zhang S  | display-authors=3  | last4=Lei  | first4=Shirley  | last5=Murage  | first5=Jaji  | last6=Fisk  | first6=Gregory J  | last7=Li  | first7=Yan  | last8=Xu  | first8=Chunhui  | last9=Fang  | first9=Rixun }}
*{{cite journal  | author=Roche J, Zeng C, Barón A, ''et al.'' |title=Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics. |journal=Leukemia |volume=18 |issue= 6 |pages= 1059-63 |year= 2004 |pmid= 15085154 |doi= 10.1038/sj.leu.2403366 }}
*{{cite journal  | author=Speleman F |title=A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias |journal=Leukemia |volume=19 |issue= 3 |pages= 358–66 |year= 2005 |pmid= 15674412 |doi= 10.1038/sj.leu.2403657  |name-list-format=vanc| author2=Cauwelier B  | author3=Dastugue N  | display-authors=3  | last4=Cools  | first4=J  | last5=Verhasselt  | first5=B  | last6=Poppe  | first6=B  | last7=Van Roy  | first7=N  | last8=Vandesompele  | first8=J  | last9=Graux  | first9=C }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Speleman F, Cauwelier B, Dastugue N, ''et al.'' |title=A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. |journal=Leukemia |volume=19 |issue= 3 |pages= 358-66 |year= 2005 |pmid= 15674412 |doi= 10.1038/sj.leu.2403657 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
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{{Transcription factors}}
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Latest revision as of 14:01, 31 August 2017

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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RefSeq (mRNA)

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Wikidata
View/Edit Human

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[3]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXB3 homeobox B3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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