HOXA7: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-A7''' is a [[protein]] that in humans is encoded by the ''HOXA7'' [[gene]].<ref name="pmid1973146">{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc =  | doi =10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc =  | doi =10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXA7 homeobox A7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3204| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HOXA7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ahd.
| PDB = {{PDB2|1ahd}}, {{PDB2|1hom}}, {{PDB2|1san}}, {{PDB2|2hoa}}, {{PDB2|9ant}}
| Name = Homeobox A7
| HGNCid = 5108
| Symbol = HOXA7
| AltSymbols =; HOX1; ANTP; HOX1.1; HOX1A
| OMIM = 142950
| ECnumber =
| Homologene = 56001
| MGIid = 96179
  | GeneAtlas_image1 = PBB_GE_HOXA7_206847_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3204
    | Hs_Ensembl = ENSG00000122592
    | Hs_RefseqProtein = NP_008827
    | Hs_RefseqmRNA = NM_006896
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 27160815
    | Hs_GenLoc_end = 27162821
    | Hs_Uniprot = P31268
    | Mm_EntrezGene = 15404
    | Mm_Ensembl = ENSMUSG00000038236
    | Mm_RefseqmRNA = NM_010455
    | Mm_RefseqProtein = NP_034585
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 52144081
    | Mm_GenLoc_end = 52147057
    | Mm_Uniprot = Q8JZW2
  }}
}}
'''Homeobox A7''', also known as '''HOXA7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXA7 homeobox A7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3204| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.<ref name="entrez">{{cite web | title = Entrez Gene: HOXA7 homeobox A7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3204| accessdate = }}</ref>
| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.<ref name="entrez">{{cite web | title = Entrez Gene: HOXA7 homeobox A7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3204| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
*{{cite journal  |vauthors=Balling R, Mutter G, Gruss P, Kessel M |title=Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. |journal=Cell |volume=58 |issue= 2 |pages= 337–47 |year= 1989 |pmid= 2568891 |doi=10.1016/0092-8674(89)90848-9 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
*{{cite journal   |vauthors=Acampora D, D'Esposito M, Faiella A, etal |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=10.1093/nar/17.24.10385  | pmc=335308 }}
*{{cite journal  | author=Balling R, Mutter G, Gruss P, Kessel M |title=Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. |journal=Cell |volume=58 |issue= 2 |pages= 337-47 |year= 1989 |pmid= 2568891 |doi=  }}
*{{cite journal   |vauthors=Boncinelli E, Acampora D, Pannese M, etal |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=  10.1139/g89-133}}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
*{{cite journal   |vauthors=Verlinsky Y, Morozov G, Gindilis V, etal |title=Homeobox gene expression in human oocytes and preembryos. |journal=Mol. Reprod. Dev. |volume=41 |issue= 2 |pages= 127–32 |year= 1995 |pmid= 7654365 |doi= 10.1002/mrd.1080410202 }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi=  }}
*{{cite journal   |vauthors=Apiou F, Flagiello D, Cillo C, etal |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=10.1159/000134320 }}
*{{cite journal | author=Verlinsky Y, Morozov G, Gindilis V, ''et al.'' |title=Homeobox gene expression in human oocytes and preembryos. |journal=Mol. Reprod. Dev. |volume=41 |issue= 2 |pages= 127-32 |year= 1995 |pmid= 7654365 |doi= 10.1002/mrd.1080410202 }}
*{{cite journal   |vauthors=Knoepfler PS, Calvo KR, Chen H, etal |title=Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14553–8 |year= 1998 |pmid= 9405651 |doi=10.1073/pnas.94.26.14553  | pmc=25052 }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi=  }}
*{{cite journal   |vauthors=Min W, Woo HJ, Lee CS, etal |title=307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation. |journal=DNA Cell Biol. |volume=17 |issue= 3 |pages= 293–9 |year= 1998 |pmid= 9539109 |doi=10.1089/dna.1998.17.293 }}
*{{cite journal | author=Knoepfler PS, Calvo KR, Chen H, ''et al.'' |title=Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14553-8 |year= 1998 |pmid= 9405651 |doi=  }}
*{{cite journal   |vauthors=McIlhatton MA, Bremner P, McMullin MF, etal |title=Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2-3 |pages= 329–33 |year= 1998 |pmid= 9804983 |doi=  10.1016/s0167-4781(98)00170-5}}
*{{cite journal | author=Min W, Woo HJ, Lee CS, ''et al.'' |title=307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation. |journal=DNA Cell Biol. |volume=17 |issue= 3 |pages= 293-9 |year= 1998 |pmid= 9539109 |doi=  }}
*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal | author=McIlhatton MA, Bremner P, McMullin MF, ''et al.'' |title=Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2-3 |pages= 329-33 |year= 1998 |pmid= 9804983 |doi=  }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal   |vauthors=Kim MH, Jin H, Seol EY, etal |title=Sequence analysis and tissue specific expression of human HOXA7. |journal=Mol. Biotechnol. |volume=14 |issue= 1 |pages= 19–24 |year= 2000 |pmid= 10911612 |doi=10.1385/MB:14:1:19 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  |vauthors=La Celle PT, Polakowska RR |title=Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32844–53 |year= 2001 |pmid= 11435435 |doi= 10.1074/jbc.M104598200 }}
*{{cite journal | author=Kim MH, Jin H, Seol EY, ''et al.'' |title=Sequence analysis and tissue specific expression of human HOXA7. |journal=Mol. Biotechnol. |volume=14 |issue= 1 |pages= 19-24 |year= 2000 |pmid= 10911612 |doi=  }}
*{{cite journal   |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal  | author=La Celle PT, Polakowska RR |title=Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32844-53 |year= 2001 |pmid= 11435435 |doi= 10.1074/jbc.M104598200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  |vauthors=Bertrand FE, Spengeman JD, Shah N, LeBien TW |title=B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression. |journal=Leukemia |volume=17 |issue= 12 |pages= 2454–9 |year= 2004 |pmid= 14562113 |doi= 10.1038/sj.leu.2403178 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bertrand FE, Spengeman JD, Shah N, LeBien TW |title=B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression. |journal=Leukemia |volume=17 |issue= 12 |pages= 2454-9 |year= 2004 |pmid= 14562113 |doi= 10.1038/sj.leu.2403178 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3204}}


== External links ==
== External links ==
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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-7-stub}}

Latest revision as of 14:00, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[3]

See also

References

  1. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. 3.0 3.1 "Entrez Gene: HOXA7 homeobox A7".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.