HIC2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Hypermethylated in cancer 2 protein''' is a [[protein]] that in humans is encoded by the ''HIC2'' [[gene]].<ref name="pmid11554746">{{cite journal |vauthors=Deltour S, Pinte S, Guerardel C, Leprince D | title = Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1 | journal = Biochem Biophys Res Commun | volume = 287 | issue = 2 | pages = 427–34 |date=Sep 2001 | pmid = 11554746 | pmc =  | doi = 10.1006/bbrc.2001.5624 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIC2 hypermethylated in cancer 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23119| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Hypermethylated in cancer 2
| HGNCid = 18595
| Symbol = HIC2
| AltSymbols =; HRG22; KIAA1020; ZBTB30
| OMIM = 607712
| ECnumber = 
| Homologene = 9020
| MGIid = 1929869
| GeneAtlas_image1 = PBB_GE_HIC2_212964_at_tn.png
| GeneAtlas_image2 = PBB_GE_HIC2_212965_at_tn.png
| GeneAtlas_image3 = PBB_GE_HIC2_212966_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23119
    | Hs_Ensembl = ENSG00000169635
    | Hs_RefseqProtein = NP_055909
    | Hs_RefseqmRNA = NM_015094
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 20101693
    | Hs_GenLoc_end = 20135748
    | Hs_Uniprot = Q96JB3
    | Mm_EntrezGene = 58180
    | Mm_Ensembl = ENSMUSG00000050240
    | Mm_RefseqmRNA = NM_178922
    | Mm_RefseqProtein = NP_849253
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 17147150
    | Mm_GenLoc_end = 17176993
    | Mm_Uniprot = Q9JLZ6
  }}
}}
'''Hypermethylated in cancer 2''', also known as '''HIC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIC2 hypermethylated in cancer 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23119| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Young TM, Wang Q, Pe'ery T, Mathews MB |title=The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6373-84 |year= 2003 |pmid= 12944466 |doi=  }}
*{{cite journal  |vauthors=Young TM, Wang Q, Pe'ery T, Mathews MB |title=The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6373–84 |year= 2003 |pmid= 12944466 |doi=10.1128/MCB.23.18.6373-6384.2003  | pmc=193714 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Deltour S, Pinte S, Guerardel C, ''et al.'' |title=The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4890-901 |year= 2002 |pmid= 12052894 |doi= }}
*{{cite journal   |vauthors=Deltour S, Pinte S, Guerardel C, etal |title=The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4890–901 |year= 2002 |pmid= 12052894 |doi=10.1128/MCB.22.13.4890-4901.2002  | pmc=133903  }}
*{{cite journal  | author=Deltour S, Pinte S, Guérardel C, Leprince D |title=Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 2 |pages= 427-34 |year= 2001 |pmid= 11554746 |doi= 10.1006/bbrc.2001.5624 }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|HIC2+protein,+human}}
* {{MeshName|HIC2+protein,+human}}
{{NLM content}}
{{Transcription factors|g2}}
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[[Category:Transcription factors]]




{{gene-22-stub}}
{{gene-22-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 13:36, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.[1][2]


References

  1. ↑ Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
  2. ↑ "Entrez Gene: HIC2 hypermethylated in cancer 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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