HES6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Transcription cofactor HES-6''' is a [[protein]] that in humans is encoded by the ''HES6'' [[gene]].<ref name="pmid10851137">{{cite journal | vauthors = Bae S, Bessho Y, Hojo M, Kageyama R | title = The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation | journal = Development | volume = 127 | issue = 13 | pages = 2933–43  | date = Aug 2000 | pmid = 10851137 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55502| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Hairy and enhancer of split 6 (Drosophila)
| HGNCid = 18254
| Symbol = HES6
| AltSymbols =;
| OMIM = 610331
| ECnumber = 
| Homologene = 23111
| MGIid = 1859852
| GeneAtlas_image1 = PBB_GE_HES6_gnf1h00306_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55502
    | Hs_Ensembl = ENSG00000144485
    | Hs_RefseqProtein = NP_061115
    | Hs_RefseqmRNA = NM_018645
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 238812207
    | Hs_GenLoc_end = 238813418
    | Hs_Uniprot = Q96HZ4
    | Mm_EntrezGene = 55927
    | Mm_Ensembl = ENSMUSG00000067071
    | Mm_RefseqmRNA = NM_019479
    | Mm_RefseqProtein = NP_062352
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 93241889
    | Mm_GenLoc_end = 93243628
    | Mm_Uniprot = Q9JHE6
  }}
}}
'''Hairy and enhancer of split 6 (Drosophila)''', also known as '''HES6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55502| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
HES6 has been shown to [[Protein-protein interaction|interact]] with [[TLE1]].<ref name=pmid11551980>{{cite journal | vauthors = Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R | title = HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | journal = J. Cell Biol. | volume = 154 | issue = 6 | pages = 1161–71  | date = Sep 2001 | pmid = 11551980 | pmc = 2150829 | doi = 10.1083/jcb.200104058 }}</ref>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF | title = Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale | journal = Acta Psychiatr Scand | volume = 52 | issue = 1 | pages = 1–6 | year = 1975 | pmid = 1155198 | doi = 10.1111/j.1600-0447.1975.tb00017.x }}
| citations =
* {{cite journal | vauthors = Vasiliauskas D, Stern CD | title = Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors | journal = Mech. Dev. | volume = 98 | issue = 1-2 | pages = 133–7 | year = 2000 | pmid = 11044617 | doi = 10.1016/S0925-4773(00)00443-3 }}
*{{cite journal | author=Bech P, Bolwig TG, Dein E, ''et al.'' |title=Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale. |journal=[[Acta Psychiatrica Scandinavica]] |volume=52 |issue= 1 |pages= 1-6 |year= 1975 |pmid= 1155198 |doi= }}
* {{cite journal | vauthors = Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R | title = HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | journal = J. Cell Biol. | volume = 154 | issue = 6 | pages = 1161–71 | year = 2001 | pmid = 11551980 | pmc = 2150829 | doi = 10.1083/jcb.200104058 }}
*{{cite journal  | author=Bae S, Bessho Y, Hojo M, Kageyama R |title=The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. |journal=Development |volume=127 |issue= 13 |pages= 2933-43 |year= 2000 |pmid= 10851137 |doi=  }}
* {{cite journal | vauthors = Swearingen ML, Sun D, Bourner M, Weinstein EJ | title = Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array | journal = Cancer Lett. | volume = 198 | issue = 2 | pages = 229–39 | year = 2003 | pmid = 12957362 | doi = 10.1016/S0304-3835(03)00313-6 }}
*{{cite journal | author=Vasiliauskas D, Stern CD |title=Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors. |journal=Mech. Dev. |volume=98 |issue= 1-2 |pages= 133-7 |year= 2001 |pmid= 11044617 |doi= }}
* {{cite journal | vauthors = Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S | title = Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms | journal = Mol. Cell. Biol. | volume = 23 | issue = 19 | pages = 6922–35 | year = 2003 | pmid = 12972610 | pmc = 193938 | doi = 10.1128/MCB.23.19.6922-6935.2003 }}
*{{cite journal | author=Gao X, Chandra T, Gratton MO, ''et al.'' |title=HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program. |journal=J. Cell Biol. |volume=154 |issue= 6 |pages= 1161-71 |year= 2001 |pmid= 11551980 |doi= 10.1083/jcb.200104058 }}
* {{cite journal | vauthors = Kang SA, Seol JH, Kim J | title = The conserved WRPW motif of Hes6 mediates proteasomal degradation | journal = Biochem. Biophys. Res. Commun. | volume = 332 | issue = 1 | pages = 33–6 | year = 2005 | pmid = 15896295 | doi = 10.1016/j.bbrc.2005.04.089 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F | title = HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion | journal = Biochem. Biophys. Res. Commun. | volume = 355 | issue = 2 | pages = 331–7 | year = 2007 | pmid = 17300753 | pmc = 1852427 | doi = 10.1016/j.bbrc.2007.01.153 }}
*{{cite journal  | author=Swearingen ML, Sun D, Bourner M, Weinstein EJ |title=Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array. |journal=Cancer Lett. |volume=198 |issue= 2 |pages= 229-39 |year= 2003 |pmid= 12957362 |doi= }}
* {{cite journal | vauthors = Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D | title = Impaired expression of Notch signaling genes in aged human skeletal muscle | journal = J. Gerontol. A Biol. Sci. Med. Sci. | volume = 62 | issue = 1 | pages = 9–17 | year = 2007 | pmid = 17301032 | doi = 10.1093/gerona/62.1.9 }}
*{{cite journal | author=Gratton MO, Torban E, Jasmin SB, ''et al.'' |title=Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6922-35 |year= 2003 |pmid= 12972610 |doi=  }}
* {{cite journal | vauthors = Scheffer D, Sage C, Corey DP, Pingault V | title = Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells | journal = FEBS Lett. | volume = 581 | issue = 24 | pages = 4651–6 | year = 2007 | pmid = 17826772 | doi = 10.1016/j.febslet.2007.08.059 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Kang SA, Seol JH, Kim J |title=The conserved WRPW motif of Hes6 mediates proteasomal degradation. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 1 |pages= 33-6 |year= 2005 |pmid= 15896295 |doi= 10.1016/j.bbrc.2005.04.089 }}
*{{cite journal | author=Ball AJ, Abrahamsson AE, Tyrberg B, ''et al.'' |title=HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 2 |pages= 331-7 |year= 2007 |pmid= 17300753 |doi= 10.1016/j.bbrc.2007.01.153 }}
*{{cite journal | author=Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D |title=Impaired expression of Notch signaling genes in aged human skeletal muscle. |journal=J. Gerontol. A Biol. Sci. Med. Sci. |volume=62 |issue= 1 |pages= 9-17 |year= 2007 |pmid= 17301032 |doi= }}
*{{cite journal | author=Scheffer D, Sage C, Corey DP, Pingault V |title=Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. |journal=FEBS Lett. |volume=581 |issue= 24 |pages= 4651-6 |year= 2007 |pmid= 17826772 |doi= 10.1016/j.febslet.2007.08.059 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|HES6+protein,+human}}
* {{MeshName|HES6+protein,+human}}


{{Transcription factors|g1}}
{{NLM content}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Revision as of 02:38, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[1][2]

Interactions

HES6 has been shown to interact with TLE1.[3]

References

  1. ↑ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.
  2. ↑ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".
  3. ↑ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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