HAND2

Heart and neural crest derivatives expressed 2
Identifiers
Symbols	HAND2 ; DHAND2; FLJ16260; Hed; MGC125303; MGC125304; Thing2; dHand
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32092
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Heart and neural crest derivatives expressed 2, also known as HAND2, is a human gene.

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

Further reading

• Srivastava D (1999). "HAND proteins: molecular mediators of cardiac development and congenital heart disease". Trends Cardiovasc. Med. 9 (1–2): 11–8. PMID 10189962.
• Firulli AB, McFadden DG, Lin Q; et al. (1998). "Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1". Nat. Genet. 18 (3): 266–70. doi:10.1038/ng0398-266. PMID 9500550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Russell MW, Kemp P, Wang L; et al. (1999). "Molecular cloning of the human HAND2 gene". Biochim. Biophys. Acta. 1443 (3): 393–9. PMID 9878849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Firulli BA, Hadzic DB, McDaid JR, Firulli AB (2000). "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function". J. Biol. Chem. 275 (43): 33567–73. doi:10.1074/jbc.M005888200. PMID 10924525.CS1 maint: Multiple names: authors list (link)
• McFadden DG, Charité J, Richardson JA; et al. (2001). "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart". Development. 127 (24): 5331–41. PMID 11076755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai YS, Cserjesi P (2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer". J. Biol. Chem. 277 (15): 12604–12. doi:10.1074/jbc.M200283200. PMID 11812799.
• Dai YS, Cserjesi P, Markham BE, Molkentin JD (2002). "The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism". J. Biol. Chem. 277 (27): 24390–8. doi:10.1074/jbc.M202490200. PMID 11994297.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srivastava D, Gottlieb PD, Olson EN (2003). "Molecular mechanisms of ventricular hypoplasia". Cold Spring Harb. Symp. Quant. Biol. 67: 121–5. PMID 12858532.CS1 maint: Multiple names: authors list (link)
• Rychlik JL, Gerbasi V, Lewis EJ (2004). "The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA". J. Biol. Chem. 278 (49): 49652–60. doi:10.1074/jbc.M308577200. PMID 14506227.CS1 maint: Multiple names: authors list (link)
• Firulli BA, Howard MJ, McDaid JR; et al. (2004). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. PMID 14636580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murakami M, Kataoka K, Tominaga J; et al. (2004). "Differential cooperation between dHAND and three different E-proteins". Biochem. Biophys. Res. Commun. 323 (1): 168–74. doi:10.1016/j.bbrc.2004.08.072. PMID 15351717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rychlik JL, Hsieh M, Eiden LE, Lewis EJ (2006). "Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type". J. Mol. Neurosci. 27 (3): 281–92. PMID 16280598.CS1 maint: Multiple names: authors list (link)
• Han Z, Yi P, Li X, Olson EN (2006). "Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis". Development. 133 (6): 1175–82. doi:10.1242/dev.02285. PMID 16467358.CS1 maint: Multiple names: authors list (link)

External links

• HAND2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.