GTF3C2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''General transcription factor 3C polypeptide 2''' is a [[protein]] that in humans is encoded by the ''GTF3C2'' [[gene]].<ref name="pmid7729686">{{cite journal | vauthors = Sinn E, Wang Z, Kovelman R, Roeder RG | title = Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 675–85  | date = Jun 1995 | pmid = 7729686 | pmc =  | doi = 10.1101/gad.9.6.675 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2976| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = General transcription factor IIIC, polypeptide 2, beta 110kDa
| HGNCid = 4665
| Symbol = GTF3C2
| AltSymbols =; KIAA0011; TFIIIC-BETA; TFIIIC110
| OMIM = 604883
| ECnumber = 
| Homologene = 37490
| MGIid = 1919002
| GeneAtlas_image1 = PBB_GE_GTF3C2_212429_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GTF3C2_204366_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GTF3C2_210620_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003709 |text = RNA polymerase III transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000127 |text = transcription factor TFIIIC complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006383 |text = transcription from RNA polymerase III promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2976
    | Hs_Ensembl = ENSG00000115207
    | Hs_RefseqProtein = NP_001030598
    | Hs_RefseqmRNA = NM_001035521
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 27402220
    | Hs_GenLoc_end = 27433372
    | Hs_Uniprot = Q8WUA4
    | Mm_EntrezGene = 71752
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_027901
    | Mm_RefseqProtein = NP_082177
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''General transcription factor IIIC, polypeptide 2, beta 110kDa''', also known as '''GTF3C2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2976| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GTF3C2 has been shown to [[Protein-protein interaction|interact]] with [[GTF3C4]]<ref name=pmid10523658>{{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7697–704 | date = Nov 1999 | pmid = 10523658 | pmc = 84812 | doi=10.1128/mcb.19.11.7697}}</ref> and [[GTF3C5]].<ref name=pmid10373544>{{cite journal | vauthors = Hsieh YJ, Wang Z, Kovelman R, Roeder RG | title = Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 4944–52  | date = Jul 1999 | pmid = 10373544 | pmc = 84305 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jang KL, Collins MK, Latchman DS | title = The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC | journal = J. Acquir. Immune Defic. Syndr. | volume = 5 | issue = 11 | pages = 1142–7 | year = 1992 | pmid = 1403646 | doi =  }}
| citations =
* {{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 | journal = DNA Res. | volume = 1 | issue = 1 | pages = 27–35 | year = 1994 | pmid = 7584026 | doi = 10.1093/dnares/1.1.27 }}
*{{cite journal | author=Jang KL, Collins MK, Latchman DS |title=The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. |journal=J. Acquir. Immune Defic. Syndr. |volume=5 |issue= 11 |pages= 1142-7 |year= 1992 |pmid= 1403646 |doi=  }}
* {{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) | journal = DNA Res. | volume = 1 | issue = 1 | pages = 47–56 | year = 1994 | pmid = 7584028 | doi = 10.1093/dnares/1.1.47 }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi= }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi= }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Sinn E, Wang Z, Kovelman R, Roeder RG |title=Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 675-85 |year= 1995 |pmid= 7729686 |doi= }}
* {{cite journal | vauthors = Chu WM, Wang Z, Roeder RG, Schmid CW | title = RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2 | journal = J. Biol. Chem. | volume = 272 | issue = 23 | pages = 14755–61 | year = 1997 | pmid = 9169441 | doi = 10.1074/jbc.272.23.14755 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Oettel S, Härtel F, Kober I, Iben S, Seifart KH | title = Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes | journal = Nucleic Acids Res. | volume = 25 | issue = 12 | pages = 2440–7 | year = 1997 | pmid = 9171097 | pmc = 146769 | doi = 10.1093/nar/25.12.2440 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Wang Z, Roeder RG | title = DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III | journal = Mol. Cell | volume = 1 | issue = 5 | pages = 749–57 | year = 1998 | pmid = 9660958 | doi = 10.1016/S1097-2765(00)80074-X }}
*{{cite journal | author=Chu WM, Wang Z, Roeder RG, Schmid CW |title=RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14755-61 |year= 1997 |pmid= 9169441 |doi= }}
* {{cite journal | vauthors = Hsieh YJ, Wang Z, Kovelman R, Roeder RG | title = Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 4944–52 | year = 1999 | pmid = 10373544 | pmc = 84305 | doi =  }}
*{{cite journal | author=Oettel S, Härtel F, Kober I, ''et al.'' |title=Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes. |journal=Nucleic Acids Res. |volume=25 |issue= 12 |pages= 2440-7 |year= 1997 |pmid= 9171097 |doi= }}
* {{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7697–704 | year = 1999 | pmid = 10523658 | pmc = 84812 | doi =  10.1128/mcb.19.11.7697}}
*{{cite journal | author=Wang Z, Roeder RG |title=DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 749-57 |year= 1998 |pmid= 9660958 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Hsieh YJ, Wang Z, Kovelman R, Roeder RG |title=Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4944-52 |year= 1999 |pmid= 10373544 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Hsieh YJ, Kundu TK, Wang Z, ''et al.'' |title=The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7697-704 |year= 1999 |pmid= 10523658 |doi= }}
* {{cite journal | vauthors = Innes F, Ramsbottom B, White RJ | title = A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC | journal = Nucleic Acids Res. | volume = 34 | issue = 11 | pages = 3399–407 | year = 2006 | pmid = 16822860 | pmc = 1488882 | doi = 10.1093/nar/gkl432 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M | title = Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC | journal = J. Biol. Chem. | volume = 282 | issue = 23 | pages = 17179–89 | year = 2007 | pmid = 17409385 | doi = 10.1074/jbc.M611542200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Innes F, Ramsbottom B, White RJ |title=A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC. |journal=Nucleic Acids Res. |volume=34 |issue= 11 |pages= 3399-407 |year= 2006 |pmid= 16822860 |doi= 10.1093/nar/gkl432 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Dumay-Odelot H, Marck C, Durrieu-Gaillard S, ''et al.'' |title=Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. |journal=J. Biol. Chem. |volume=282 |issue= 23 |pages= 17179-89 |year= 2007 |pmid= 17409385 |doi= 10.1074/jbc.M611542200 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|GTF3C2+protein,+human}}
* {{MeshName|GTF3C2+protein,+human}}
* {{FactorBook|TFIIIC-110}}


{{NLM content}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 15:38, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.[1][2]

Interactions

GTF3C2 has been shown to interact with GTF3C4[3] and GTF3C5.[4]

References

  1. ↑ Sinn E, Wang Z, Kovelman R, Roeder RG (Jun 1995). "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors". Genes Dev. 9 (6): 675–85. doi:10.1101/gad.9.6.675. PMID 7729686.
  2. ↑ "Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa".
  3. ↑ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  4. ↑ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=GTF3C2&oldid=1412291"