GTF2I: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''General transcription factor II-I''' is a [[protein]] that in humans is encoded by the ''GTF2I'' [[gene]].<ref name="pmid9334314">{{cite journal | vauthors = Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M | title = A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I | journal = Genes & Development | volume = 11 | issue = 19 | pages = 2482–93 | date = Oct 1997 | pmid = 9334314 | pmc = 316568 | doi = 10.1101/gad.11.19.2482 }}</ref><ref name="pmid9012831">{{cite journal | vauthors = Yang W, Desiderio S | title = BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 2 | pages = 604–9 | date = Jan 1997 | pmid = 9012831 | pmc = 19560 | doi = 10.1073/pnas.94.2.604 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF2I general transcription factor II, i| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2969| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GTF2I_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q60.
| PDB = {{PDB2|1q60}}, {{PDB2|2d9b}}, {{PDB2|2dn4}}
| Name = General transcription factor II, i
| HGNCid = 4659
| Symbol = GTF2I
| AltSymbols =; WBS; BAP-135; BAP135; BTKAP1; DIWS; IB291; SPIN; TFII-I; WBSCR6
| OMIM = 601679
| ECnumber = 
| Homologene = 7748
| MGIid = 1202722
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2969
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001130609
    | Hs_RefseqmRNA = XM_001130609
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 14886
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_903569
    | Mm_RefseqProtein = XP_908662
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''General transcription factor II, i''', also known as '''GTF2I''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF2I general transcription factor II, i| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2969| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in [[Williams-Beuren syndrome]], a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: GTF2I general transcription factor II, i| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2969| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GTF2I has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Bruton's tyrosine kinase]],<ref name = pmid9012831 /><ref name = pmid14623887>{{cite journal | vauthors = Sacristán C, Tussié-Luna MI, Logan SM, Roy AL | title = Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I | journal = The Journal of Biological Chemistry | volume = 279 | issue = 8 | pages = 7147–58 | date = Feb 2004 | pmid = 14623887 | doi = 10.1074/jbc.M303724200 }}</ref><ref name = pmid10373551>{{cite journal | vauthors = Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL | title = Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5014–24 | date = Jul 1999 | pmid = 10373551 | pmc = 84330 | doi =  10.1128/mcb.19.7.5014}}</ref>
* [[HDAC3]],<ref name = pmid12393887/><ref name = pmid12239342>{{cite journal | vauthors = Tussié-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL | title = Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 20 | pages = 12807–12 | date = Oct 2002 | pmid = 12239342 | pmc = 130541 | doi = 10.1073/pnas.192464499 }}</ref>
* [[Histone deacetylase 2]],<ref name = pmid12393887>{{cite journal | vauthors = Wen YD, Cress WD, Roy AL, Seto E | title = Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I | journal = The Journal of Biological Chemistry | volume = 278 | issue = 3 | pages = 1841–7 | date = Jan 2003 | pmid = 12393887 | doi = 10.1074/jbc.M206528200 }}</ref><ref name = pmid12493763>{{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = Feb 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}</ref>
* [[MAPK3]],<ref name = pmid10648599>{{cite journal | vauthors = Kim DW, Cochran BH | title = Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter | journal = Molecular and Cellular Biology | volume = 20 | issue = 4 | pages = 1140–8 | date = Feb 2000 | pmid = 10648599 | pmc = 85232 | doi =  10.1128/mcb.20.4.1140-1148.2000}}</ref>
* [[Myc]],<ref name = pmid8377829>{{cite journal | vauthors = Roy AL, Carruthers C, Gutjahr T, Roeder RG | title = Direct role for Myc in transcription initiation mediated by interactions with TFII-I |journal =[[Nature (journal)|Nature]] |volume = 365 | issue = 6444 | pages = 359–61 | date = Sep 1993 | pmid = 8377829 | doi = 10.1038/365359a0 }}</ref>
* [[PRKG1]],<ref name = pmid12082086>{{cite journal | vauthors = Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB | title = cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I | journal = The Journal of Biological Chemistry | volume = 277 | issue = 35 | pages = 32003–14 | date = Aug 2002 | pmid = 12082086 | doi = 10.1074/jbc.M112332200 }}</ref>
* [[Serum response factor]]<ref name = pmid9334314 /><ref name = pmid9584171>{{cite journal | vauthors = Kim DW, Cheriyath V, Roy AL, Cochran BH | title = TFII-I enhances activation of the c-fos promoter through interactions with upstream elements | journal = Molecular and Cellular Biology | volume = 18 | issue = 6 | pages = 3310–20 | date = Jun 1998 | pmid = 9584171 | pmc = 108912 | doi =  10.1128/mcb.18.6.3310}}</ref>  and
* [[USF1 (human gene)]].<ref name = pmid9384587>{{cite journal | vauthors = Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG | title = Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1 | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 7091–104 | date = Dec 1997 | pmid = 9384587 | pmc = 1170311 | doi = 10.1093/emboj/16.23.7091 }}</ref><ref name = pmid1961251>{{cite journal | vauthors = Roy AL, Meisterernst M, Pognonec P, Roeder RG | title = Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF | journal = Nature | volume = 354 | issue = 6350 | pages = 245–8 | date = Nov 1991 | pmid = 1961251 | doi = 10.1038/354245a0 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Roy AL, Meisterernst M, Pognonec P, Roeder RG | title = Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF | journal = Nature | volume = 354 | issue = 6350 | pages = 245–8 | date = Nov 1991 | pmid = 1961251 | doi = 10.1038/354245a0 }}
| citations =
* {{cite journal | vauthors = Roy AL, Carruthers C, Gutjahr T, Roeder RG | title = Direct role for Myc in transcription initiation mediated by interactions with TFII-I | journal = Nature | volume = 365 | issue = 6444 | pages = 359–61 | date = Sep 1993 | pmid = 8377829 | doi = 10.1038/365359a0 }}
*{{cite journal | author=Roy AL, Meisterernst M, Pognonec P, Roeder RG |title=Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. |journal=Nature |volume=354 |issue= 6350 |pages= 245-8 |year= 1992 |pmid= 1961251 |doi= 10.1038/354245a0 }}
* {{cite journal | vauthors = Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG | title = Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1 | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 7091–104 | date = Dec 1997 | pmid = 9384587 | pmc = 1170311 | doi = 10.1093/emboj/16.23.7091 }}
*{{cite journal | author=Roy AL, Carruthers C, Gutjahr T, Roeder RG |title=Direct role for Myc in transcription initiation mediated by interactions with TFII-I. |journal=Nature |volume=365 |issue= 6444 |pages= 359-61 |year= 1993 |pmid= 8377829 |doi= 10.1038/365359a0 }}
* {{cite journal | vauthors = Pérez Jurado LA, Wang YK, Peoples R, Coloma A, Cruces J, Francke U | title = A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK | journal = Human Molecular Genetics | volume = 7 | issue = 3 | pages = 325–34 | date = Mar 1998 | pmid = 9466987 | doi = 10.1093/hmg/7.3.325 }}
*{{cite journal | author=Yang W, Desiderio S |title=BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 2 |pages= 604-9 |year= 1997 |pmid= 9012831 |doi= }}
* {{cite journal | vauthors = Kim DW, Cheriyath V, Roy AL, Cochran BH | title = TFII-I enhances activation of the c-fos promoter through interactions with upstream elements | journal = Molecular and Cellular Biology | volume = 18 | issue = 6 | pages = 3310–20 | date = Jun 1998 | pmid = 9584171 | pmc = 108912 | doi =  10.1128/mcb.18.6.3310}}
*{{cite journal  | author=Grueneberg DA, Henry RW, Brauer A, ''et al.'' |title=A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I. |journal=Genes Dev. |volume=11 |issue= 19 |pages= 2482-93 |year= 1997 |pmid= 9334314 |doi=  }}
* {{cite journal | vauthors = Cheriyath V, Novina CD, Roy AL | title = TFII-I regulates Vbeta promoter activity through an initiator element | journal = Molecular and Cellular Biology | volume = 18 | issue = 8 | pages = 4444–54 | date = Aug 1998 | pmid = 9671454 | pmc = 109030 | doi =  10.1128/mcb.18.8.4444}}
*{{cite journal | author=Roy AL, Du H, Gregor PD, ''et al.'' |title=Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1. |journal=EMBO J. |volume=16 |issue= 23 |pages= 7091-104 |year= 1998 |pmid= 9384587 |doi= 10.1093/emboj/16.23.7091 }}
* {{cite journal | vauthors = Novina CD, Cheriyath V, Roy AL | title = Regulation of TFII-I activity by phosphorylation | journal = The Journal of Biological Chemistry | volume = 273 | issue = 50 | pages = 33443–8 | date = Dec 1998 | pmid = 9837922 | doi = 10.1074/jbc.273.50.33443 }}
*{{cite journal | author=Pérez Jurado LA, Wang YK, Peoples R, ''et al.'' |title=A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK. |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 325-34 |year= 1998 |pmid= 9466987 |doi=  }}
* {{cite journal | vauthors = Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL | title = Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5014–24 | date = Jul 1999 | pmid = 10373551 | pmc = 84330 | doi =  10.1128/mcb.19.7.5014}}
*{{cite journal | author=Kim DW, Cheriyath V, Roy AL, Cochran BH |title=TFII-I enhances activation of the c-fos promoter through interactions with upstream elements. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3310-20 |year= 1998 |pmid= 9584171 |doi=  }}
* {{cite journal | vauthors = Kim DW, Cochran BH | title = Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter | journal = Molecular and Cellular Biology | volume = 20 | issue = 4 | pages = 1140–8 | date = Feb 2000 | pmid = 10648599 | pmc = 85232 | doi = 10.1128/MCB.20.4.1140-1148.2000 }}
*{{cite journal | author=Cheriyath V, Novina CD, Roy AL |title=TFII-I regulates Vbeta promoter activity through an initiator element. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4444-54 |year= 1998 |pmid= 9671454 |doi= }}
* {{cite journal | vauthors = Cheriyath V, Roy AL | title = Alternatively spliced isoforms of TFII-I. Complex formation, nuclear translocation, and differential gene regulation | journal = The Journal of Biological Chemistry | volume = 275 | issue = 34 | pages = 26300–8 | date = Aug 2000 | pmid = 10854432 | doi = 10.1074/jbc.M002980200 }}
*{{cite journal | author=Novina CD, Cheriyath V, Roy AL |title=Regulation of TFII-I activity by phosphorylation. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33443-8 |year= 1999 |pmid= 9837922 |doi=  }}
* {{cite journal | vauthors = Parker R, Phan T, Baumeister P, Roy B, Cheriyath V, Roy AL, Lee AS | title = Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6 | journal = Molecular and Cellular Biology | volume = 21 | issue = 9 | pages = 3220–33 | date = May 2001 | pmid = 11287625 | pmc = 86961 | doi = 10.1128/MCB.21.9.3220-3233.2001 }}
*{{cite journal | author=Novina CD, Kumar S, Bajpai U, ''et al.'' |title=Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5014-24 |year= 1999 |pmid= 10373551 |doi= }}
* {{cite journal | vauthors = Kim DW, Cochran BH | title = JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase | journal = Molecular and Cellular Biology | volume = 21 | issue = 10 | pages = 3387–97 | date = May 2001 | pmid = 11313464 | pmc = 100260 | doi = 10.1128/MCB.21.10.3387-3397.2000 }}
*{{cite journal | author=Kim DW, Cochran BH |title=Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter. |journal=Mol. Cell. Biol. |volume=20 |issue= 4 |pages= 1140-8 |year= 2000 |pmid= 10648599 |doi= }}
* {{cite journal | vauthors = Egloff AM, Desiderio S | title = Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I | journal = The Journal of Biological Chemistry | volume = 276 | issue = 30 | pages = 27806–15 | date = Jul 2001 | pmid = 11373296 | doi = 10.1074/jbc.M103692200 }}
*{{cite journal | author=Cheriyath V, Roy AL |title=Alternatively spliced isoforms of TFII-I. Complex formation, nuclear translocation, and differential gene regulation. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26300-8 |year= 2000 |pmid= 10854432 |doi= 10.1074/jbc.M002980200 }}
* {{cite journal | vauthors = Cheriyath V, Desgranges ZP, Roy AL | title = c-Src-dependent transcriptional activation of TFII-I | journal = The Journal of Biological Chemistry | volume = 277 | issue = 25 | pages = 22798–805 | date = Jun 2002 | pmid = 11934902 | doi = 10.1074/jbc.M202956200 }}
*{{cite journal | author=Parker R, Phan T, Baumeister P, ''et al.'' |title=Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 3220-33 |year= 2001 |pmid= 11287625 |doi= 10.1128/MCB.21.9.3220-3233.2001 }}
* {{cite journal | vauthors = Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB | title = cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I | journal = The Journal of Biological Chemistry | volume = 277 | issue = 35 | pages = 32003–14 | date = Aug 2002 | pmid = 12082086 | doi = 10.1074/jbc.M112332200 }}
*{{cite journal | author=Kim DW, Cochran BH |title=JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase. |journal=Mol. Cell. Biol. |volume=21 |issue= 10 |pages= 3387-97 |year= 2001 |pmid= 11313464 |doi= 10.1128/MCB.21.10.3387-3397.2000 }}
* {{cite journal | vauthors = Tussie-Luna MI, Michel B, Hakre S, Roy AL | title = The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43185–93 | date = Nov 2002 | pmid = 12193603 | doi = 10.1074/jbc.M207635200 }}
*{{cite journal | author=Egloff AM, Desiderio S |title=Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27806-15 |year= 2001 |pmid= 11373296 |doi= 10.1074/jbc.M103692200 }}
* {{cite journal | vauthors = Tussié-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL | title = Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 20 | pages = 12807–12 | date = Oct 2002 | pmid = 12239342 | pmc = 130541 | doi = 10.1073/pnas.192464499 }}
*{{cite journal | author=Cheriyath V, Desgranges ZP, Roy AL |title=c-Src-dependent transcriptional activation of TFII-I. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22798-805 |year= 2002 |pmid= 11934902 |doi= 10.1074/jbc.M202956200 }}
* {{cite journal | vauthors = Wen YD, Cress WD, Roy AL, Seto E | title = Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I | journal = The Journal of Biological Chemistry | volume = 278 | issue = 3 | pages = 1841–7 | date = Jan 2003 | pmid = 12393887 | doi = 10.1074/jbc.M206528200 }}
*{{cite journal | author=Casteel DE, Zhuang S, Gudi T, ''et al.'' |title=cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32003-14 |year= 2002 |pmid= 12082086 |doi= 10.1074/jbc.M112332200 }}
*{{cite journal | author=Tussie-Luna MI, Michel B, Hakre S, Roy AL |title=The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43185-93 |year= 2003 |pmid= 12193603 |doi= 10.1074/jbc.M207635200 }}
*{{cite journal | author=Tussié-Luna MI, Bayarsaihan D, Seto E, ''et al.'' |title=Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12807-12 |year= 2002 |pmid= 12239342 |doi= 10.1073/pnas.192464499 }}
*{{cite journal  | author=Wen YD, Cress WD, Roy AL, Seto E |title=Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1841-7 |year= 2003 |pmid= 12393887 |doi= 10.1074/jbc.M206528200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|GTF2I+protein,+human}}
* {{MeshName|GTF2I+protein,+human}}


{{NLM content}}
{{PDB Gallery|geneid=2969}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 09:08, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene.[1][2][3]

Function

This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.[3]

Interactions

GTF2I has been shown to interact with:

References

  1. ↑ 1.0 1.1 Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M (Oct 1997). "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes & Development. 11 (19): 2482–93. doi:10.1101/gad.11.19.2482. PMC 316568. PMID 9334314.
  2. ↑ 2.0 2.1 Yang W, Desiderio S (Jan 1997). "BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement". Proceedings of the National Academy of Sciences of the United States of America. 94 (2): 604–9. doi:10.1073/pnas.94.2.604. PMC 19560. PMID 9012831.
  3. ↑ 3.0 3.1 "Entrez Gene: GTF2I general transcription factor II, i".
  4. ↑ Sacristán C, Tussié-Luna MI, Logan SM, Roy AL (Feb 2004). "Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I". The Journal of Biological Chemistry. 279 (8): 7147–58. doi:10.1074/jbc.M303724200. PMID 14623887.
  5. ↑ Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL (Jul 1999). "Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase". Molecular and Cellular Biology. 19 (7): 5014–24. doi:10.1128/mcb.19.7.5014. PMC 84330. PMID 10373551.
  6. ↑ 6.0 6.1 Wen YD, Cress WD, Roy AL, Seto E (Jan 2003). "Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". The Journal of Biological Chemistry. 278 (3): 1841–7. doi:10.1074/jbc.M206528200. PMID 12393887.
  7. ↑ Tussié-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL (Oct 2002). "Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta". Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 12807–12. doi:10.1073/pnas.192464499. PMC 130541. PMID 12239342.
  8. ↑ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
  9. ↑ Kim DW, Cochran BH (Feb 2000). "Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter". Molecular and Cellular Biology. 20 (4): 1140–8. doi:10.1128/mcb.20.4.1140-1148.2000. PMC 85232. PMID 10648599.
  10. ↑ Roy AL, Carruthers C, Gutjahr T, Roeder RG (Sep 1993). "Direct role for Myc in transcription initiation mediated by interactions with TFII-I". Nature. 365 (6444): 359–61. doi:10.1038/365359a0. PMID 8377829.
  11. ↑ Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. 277 (35): 32003–14. doi:10.1074/jbc.M112332200. PMID 12082086.
  12. ↑ Kim DW, Cheriyath V, Roy AL, Cochran BH (Jun 1998). "TFII-I enhances activation of the c-fos promoter through interactions with upstream elements". Molecular and Cellular Biology. 18 (6): 3310–20. doi:10.1128/mcb.18.6.3310. PMC 108912. PMID 9584171.
  13. ↑ Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
  14. ↑ Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.

Further reading

External links

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