GTF2H1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''General transcription factor IIH subunit 1''' is a [[protein]] that in humans is encoded by the ''GTF2H1'' [[gene]].<ref name="pmid1529339">{{cite journal | vauthors = Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM | title = Cloning of the 62-kilodalton component of basic transcription factor BTF2 | journal = Science | volume = 257 | issue = 5075 | pages = 1392–5  | date = October 1992 | pmid = 1529339 | pmc =  | doi = 10.1126/science.1529339 }}</ref><ref name="pmid8162052">{{cite journal | vauthors = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4  | date = May 1994 | pmid = 8162052 | pmc =  | doi = 10.1093/hmg/3.1.61 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2965| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_GTF2H1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pfj.
| PDB = {{PDB2|1pfj}}, {{PDB2|2dii}}
| Name = General transcription factor IIH, polypeptide 1, 62kDa
| HGNCid = 4655
| Symbol = GTF2H1
| AltSymbols =; BTF2; TFIIH
| OMIM = 189972
| ECnumber = 
| Homologene = 3885
| MGIid = 1277216
| GeneAtlas_image1 = PBB_GE_GTF2H1_202451_at_tn.png
| GeneAtlas_image2 = PBB_GE_GTF2H1_202453_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008353 |text = RNA polymerase subunit kinase activity}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2965
    | Hs_Ensembl = ENSG00000110768
    | Hs_RefseqProtein = NP_005307
    | Hs_RefseqmRNA = NM_005316
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 18300719
    | Hs_GenLoc_end = 18345152
    | Hs_Uniprot = P32780
    | Mm_EntrezGene = 14884
    | Mm_Ensembl = ENSMUSG00000006599
    | Mm_RefseqmRNA = NM_008186
    | Mm_RefseqProtein = NP_032212
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 46664145
    | Mm_GenLoc_end = 46691839
    | Mm_Uniprot = Q7TPY0
  }}
}}
'''General transcription factor IIH, polypeptide 1, 62kDa''', also known as '''GTF2H1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2965| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GTF2H1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[Cyclin-dependent kinase 7]],<ref name = pmid9130708/><ref name = pmid7533895>{{cite journal | vauthors = Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D | title = Cdk-activating kinase complex is a component of human transcription factor TFIIH | journal = Nature | volume = 374 | issue = 6519 | pages = 283–7  | date = March 1995 | pmid = 7533895 | doi = 10.1038/374283a0 }}</ref><ref name = pmid8521393>{{cite journal | vauthors = Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y | title = Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor | journal = Cancer Res. | volume = 55 | issue = 24 | pages = 6058–62  | date = December 1995 | pmid = 8521393 | doi =  }}</ref>
| summary_text =  
* [[E2F1]],<ref name = pmid10428966>{{cite journal | vauthors = Vandel L, Kouzarides T | title = Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase | journal = EMBO J. | volume = 18 | issue = 15 | pages = 4280–91  | date = August 1999 | pmid = 10428966 | pmc = 1171504 | doi = 10.1093/emboj/18.15.4280 }}</ref>
}}
* [[ERCC2]],<ref name = pmid9130708/><ref name = pmid8152490>{{cite journal | vauthors = Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D | title = Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II | journal = Nature | volume = 368 | issue = 6473 | pages = 769–72  | date = April 1994 | pmid = 8152490 | doi = 10.1038/368769a0 }}</ref>
* [[Estrogen receptor alpha]],<ref name = pmid10949034>{{cite journal | vauthors = Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S | title = Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7 | journal = Mol. Cell | volume = 6 | issue = 1 | pages = 127–37  | date = July 2000 | pmid = 10949034 | doi = 10.1016/s1097-2765(00)00014-9}}</ref>  
* [[TCEA1]],<ref name = pmid9765293>{{cite journal | vauthors = Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J | title = FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO | journal = J. Biol. Chem. | volume = 273 | issue = 42 | pages = 27593–601  | date = October 1998 | pmid = 9765293 | doi =  10.1074/jbc.273.42.27593}}</ref><ref name = pmid9305922>{{cite journal | vauthors = Pan G, Aso T, Greenblatt J | title = Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators | journal = J. Biol. Chem. | volume = 272 | issue = 39 | pages = 24563–71  | date = September 1997 | pmid = 9305922 | doi =  10.1074/jbc.272.39.24563}}</ref> and
* [[XPB]].<ref name = pmid9130708>{{cite journal | vauthors = Rossignol M, Kolb-Cheynel I, Egly JM | title = Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH | journal = EMBO J. | volume = 16 | issue = 7 | pages = 1628–37  | date = April 1997 | pmid = 9130708 | pmc = 1169767 | doi = 10.1093/emboj/16.7.1628 }}</ref><ref name = pmid15220921>{{cite journal | vauthors = Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W | title = A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A | journal = Nat. Genet. | volume = 36 | issue = 7 | pages = 714–9  | date = July 2004 | pmid = 15220921 | doi = 10.1038/ng1387 }}</ref><ref name = pmid9118947>{{cite journal | vauthors = Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM | title = Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH | journal = EMBO J. | volume = 16 | issue = 5 | pages = 1093–102  | date = March 1997 | pmid = 9118947 | pmc = 1169708 | doi = 10.1093/emboj/16.5.1093 }}</ref>
{{Div col end}}


==See also==
== See also ==
* [[Transcription Factor II H]]
* [[Transcription Factor II H]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
{{Clear}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jeang KT | title = Tat, Tat-associated kinase, and transcription | journal = J. Biomed. Sci. | volume = 5 | issue = 1 | pages = 24–7 | year = 1998 | pmid = 9570510 | doi = 10.1007/BF02253352 }}
| citations =
* {{cite journal | vauthors = Yankulov K, Bentley D | title = Transcriptional control: Tat cofactors and transcriptional elongation | journal = Curr. Biol. | volume = 8 | issue = 13 | pages = R447-9 | year = 1998 | pmid = 9651670 | doi = 10.1016/S0960-9822(98)70289-1 }}
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
* {{cite journal | vauthors = Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D | title = Cdk-activating kinase complex is a component of human transcription factor TFIIH | journal = Nature | volume = 374 | issue = 6519 | pages = 283–7 | year = 1995 | pmid = 7533895 | doi = 10.1038/374283a0 }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
* {{cite journal | vauthors = Tong X, Drapkin R, Reinberg D, Kieff E | title = The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 8 | pages = 3259–63 | year = 1995 | pmid = 7724549 | pmc = 42145 | doi = 10.1073/pnas.92.8.3259 }}
*{{cite journal | author=Fischer L, Gerard M, Chalut C, ''et al.'' |title=Cloning of the 62-kilodalton component of basic transcription factor BTF2. |journal=Science |volume=257 |issue= 5075 |pages= 1392-5 |year= 1992 |pmid= 1529339 |doi= }}
* {{cite journal | vauthors = Fantes JA, Oghene K, Boyle S, Danes S, Fletcher JM, Bruford EA, Williamson K, Seawright A, Schedl A, Hanson I | title = A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1 | journal = Genomics | volume = 25 | issue = 2 | pages = 447–61 | year = 1995 | pmid = 7789978 | doi = 10.1016/0888-7543(95)80045-N }}
*{{cite journal | author=Shiekhattar R, Mermelstein F, Fisher RP, ''et al.'' |title=Cdk-activating kinase complex is a component of human transcription factor TFIIH. |journal=Nature |volume=374 |issue= 6519 |pages= 283-7 |year= 1995 |pmid= 7533895 |doi= 10.1038/374283a0 }}
* {{cite journal | vauthors = Xiao H, Pearson A, Coulombe B, Truant R, Zhang S, Regier JL, Triezenberg SJ, Reinberg D, Flores O, Ingles CJ | title = Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53 | journal = Mol. Cell. Biol. | volume = 14 | issue = 10 | pages = 7013–24 | year = 1994 | pmid = 7935417 | pmc = 359231 | doi =  10.1128/mcb.14.10.7013}}
*{{cite journal | author=Tong X, Drapkin R, Reinberg D, Kieff E |title=The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 8 |pages= 3259-63 |year= 1995 |pmid= 7724549 |doi= }}
* {{cite journal | vauthors = Schaeffer L, Moncollin V, Roy R, Staub A, Mezzina M, Sarasin A, Weeda G, Hoeijmakers JH, Egly JM | title = The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor | journal = EMBO J. | volume = 13 | issue = 10 | pages = 2388–92 | year = 1994 | pmid = 8194528 | pmc = 395103 | doi =  }}
*{{cite journal | author=Fantes JA, Oghene K, Boyle S, ''et al.'' |title=A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1. |journal=Genomics |volume=25 |issue= 2 |pages= 447-61 |year= 1995 |pmid= 7789978 |doi=  }}
* {{cite journal | vauthors = Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D | title = Three functional classes of transcriptional activation domain | journal = Mol. Cell. Biol. | volume = 16 | issue = 5 | pages = 2044–55 | year = 1996 | pmid = 8628270 | pmc = 231191 | doi =  }}
*{{cite journal | author=Xiao H, Pearson A, Coulombe B, ''et al.'' |title=Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. |journal=Mol. Cell. Biol. |volume=14 |issue= 10 |pages= 7013-24 |year= 1994 |pmid= 7935417 |doi=  }}
* {{cite journal | vauthors = Iyer N, Reagan MS, Wu KJ, Canagarajah B, Friedberg EC | title = Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein | journal = Biochemistry | volume = 35 | issue = 7 | pages = 2157–67 | year = 1996 | pmid = 8652557 | doi = 10.1021/bi9524124 }}
*{{cite journal | author=Heng HH, Xiao H, Shi XM, ''et al.'' |title=Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. |journal=Hum. Mol. Genet. |volume=3 |issue= 1 |pages= 61-4 |year= 1994 |pmid= 8162052 |doi=  }}
* {{cite journal | vauthors = Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ | title = Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 13 | pages = 6482–7 | year = 1996 | pmid = 8692841 | pmc = 39049 | doi = 10.1073/pnas.93.13.6482 }}
*{{cite journal | author=Schaeffer L, Moncollin V, Roy R, ''et al.'' |title=The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. |journal=EMBO J. |volume=13 |issue= 10 |pages= 2388-92 |year= 1994 |pmid= 8194528 |doi= }}
* {{cite journal | vauthors = Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D | title = Human cyclin-dependent kinase-activating kinase exists in three distinct complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 13 | pages = 6488–93 | year = 1996 | pmid = 8692842 | pmc = 39050 | doi = 10.1073/pnas.93.13.6488 }}
*{{cite journal | author=Blau J, Xiao H, McCracken S, ''et al.'' |title=Three functional classes of transcriptional activation domain. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2044-55 |year= 1996 |pmid= 8628270 |doi= }}
* {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | year = 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 }}
*{{cite journal | author=Iyer N, Reagan MS, Wu KJ, ''et al.'' |title=Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. |journal=Biochemistry |volume=35 |issue= 7 |pages= 2157-67 |year= 1996 |pmid= 8652557 |doi= 10.1021/bi9524124 }}
* {{cite journal | vauthors = Parada CA, Roeder RG | title = Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain | journal = Nature | volume = 384 | issue = 6607 | pages = 375–8 | year = 1996 | pmid = 8934526 | doi = 10.1038/384375a0 }}
*{{cite journal | author=Reardon JT, Ge H, Gibbs E, ''et al.'' |title=Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6482-7 |year= 1996 |pmid= 8692841 |doi= }}
* {{cite journal | vauthors = García-Martínez LF, Ivanov D, Gaynor RB | title = Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes | journal = J. Biol. Chem. | volume = 272 | issue = 11 | pages = 6951–8 | year = 1997 | pmid = 9054383 | doi = 10.1074/jbc.272.11.6951 }}
*{{cite journal | author=Drapkin R, Le Roy G, Cho H, ''et al.'' |title=Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6488-93 |year= 1996 |pmid= 8692842 |doi= }}
* {{cite journal | vauthors = Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM | title = Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH | journal = EMBO J. | volume = 16 | issue = 5 | pages = 1093–102 | year = 1997 | pmid = 9118947 | pmc = 1169708 | doi = 10.1093/emboj/16.5.1093 }}
*{{cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605-10 |year= 1996 |pmid= 8849451 |doi= }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1817–23 | year = 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
*{{cite journal | author=Parada CA, Roeder RG |title=Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. |journal=Nature |volume=384 |issue= 6607 |pages= 375-8 |year= 1996 |pmid= 8934526 |doi= 10.1038/384375a0 }}
* {{cite journal | vauthors = Rossignol M, Kolb-Cheynel I, Egly JM | title = Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH | journal = EMBO J. | volume = 16 | issue = 7 | pages = 1628–37 | year = 1997 | pmid = 9130708 | pmc = 1169767 | doi = 10.1093/emboj/16.7.1628 }}
*{{cite journal | author=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951-8 |year= 1997 |pmid= 9054383 |doi=  }}
* {{cite journal | vauthors = García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB | title = Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription | journal = EMBO J. | volume = 16 | issue = 10 | pages = 2836–50 | year = 1997 | pmid = 9184228 | pmc = 1169892 | doi = 10.1093/emboj/16.10.2836 }}
*{{cite journal | author=Marinoni JC, Roy R, Vermeulen W, ''et al.'' |title=Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. |journal=EMBO J. |volume=16 |issue= 5 |pages= 1093-102 |year= 1997 |pmid= 9118947 |doi= 10.1093/emboj/16.5.1093 }}
*{{cite journal | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817-23 |year= 1997 |pmid= 9121429 |doi=  }}
*{{cite journal  | author=Rossignol M, Kolb-Cheynel I, Egly JM |title=Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. |journal=EMBO J. |volume=16 |issue= 7 |pages= 1628-37 |year= 1997 |pmid= 9130708 |doi= 10.1093/emboj/16.7.1628 }}
*{{cite journal  | author=García-Martínez LF, Mavankal G, Neveu JM, ''et al.'' |title=Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2836-50 |year= 1997 |pmid= 9184228 |doi= 10.1093/emboj/16.10.2836 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|GTF2H1+protein,+human}}
* {{MeshName|GTF2H1+protein,+human}}


{{PDB Gallery|geneid=2965}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 09:08, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.[1][2][3]

Interactions

GTF2H1 has been shown to interact with:

See also

References

  1. ↑ Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science. 257 (5075): 1392–5. doi:10.1126/science.1529339. PMID 1529339.
  2. ↑ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
  3. ↑ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa".
  4. ↑ 4.0 4.1 4.2 Rossignol M, Kolb-Cheynel I, Egly JM (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
  5. ↑ Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. doi:10.1038/374283a0. PMID 7533895.
  6. ↑ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.
  7. ↑ Vandel L, Kouzarides T (August 1999). "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase". EMBO J. 18 (15): 4280–91. doi:10.1093/emboj/18.15.4280. PMC 1171504. PMID 10428966.
  8. ↑ Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature. 368 (6473): 769–72. doi:10.1038/368769a0. PMID 8152490.
  9. ↑ Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S (July 2000). "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell. 6 (1): 127–37. doi:10.1016/s1097-2765(00)00014-9. PMID 10949034.
  10. ↑ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
  11. ↑ Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
  12. ↑ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.
  13. ↑ Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (March 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.

Further reading

External links

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