GATA4

GATA binding protein 4
Identifiers
Symbols	GATA4 ; MGC126629
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1551
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GATA binding protein 4, also known as GATA4, is a human gene.

This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.

See also

• GATA transcription factor

Further reading

• Evans T, Reitman M, Felsenfeld G (1988). "An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes". Proc. Natl. Acad. Sci. U.S.A. 85 (16): 5976–80. PMID 3413070.CS1 maint: Multiple names: authors list (link)
• White RA, Dowler LL, Pasztor LM; et al. (1995). "Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization)". Genomics. 27 (1): 20–6. doi:10.1006/geno.1995.1003. PMID 7665171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang WY, Cukerman E, Liew CC (1995). "Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA". Gene. 155 (2): 219–23. PMID 7721094.CS1 maint: Multiple names: authors list (link)
• Yamagata T, Nishida J, Sakai R; et al. (1995). "Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins". Mol. Cell. Biol. 15 (7): 3830–9. PMID 7791790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Molkentin JD, Kalvakolanu DV, Markham BE (1994). "Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene". Mol. Cell. Biol. 14 (7): 4947–57. PMID 8007990.CS1 maint: Multiple names: authors list (link)
• Arceci RJ, King AA, Simon MC; et al. (1993). "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart". Mol. Cell. Biol. 13 (4): 2235–46. PMID 8455608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang WY, Heng HH, Liew CC (1997). "Assignment of the human GATA4 gene to 8p23.1-->p22 using fluorescence in situ hybridization analysis". Cytogenet. Cell Genet. 72 (2–3): 217–8. PMID 8978781.CS1 maint: Multiple names: authors list (link)
• Herzig TC, Jobe SM, Aoki H; et al. (1997). "Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7543–8. PMID 9207128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Durocher D, Charron F, Warren R; et al. (1997). "The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors". EMBO J. 16 (18): 5687–96. doi:10.1093/emboj/16.18.5687. PMID 9312027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Molkentin JD, Lu JR, Antos CL; et al. (1998). "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy". Cell. 93 (2): 215–28. PMID 9568714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Svensson EC, Tufts RL, Polk CE, Leiden JM (1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 956–61. PMID 9927675.CS1 maint: Multiple names: authors list (link)
• Tremblay JJ, Viger RS (1999). "Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1". Mol. Endocrinol. 13 (8): 1388–401. PMID 10446911.
• Lin L, Aggarwal S, Glover TW; et al. (2000). "A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene". Cancer Res. 60 (5): 1341–7. PMID 10728696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morin S, Charron F, Robitaille L, Nemer M (2000). "GATA-dependent recruitment of MEF2 proteins to target promoters". EMBO J. 19 (9): 2046–55. doi:10.1093/emboj/19.9.2046. PMID 10790371.CS1 maint: Multiple names: authors list (link)
• Zhu W, Shiojima I, Hiroi Y; et al. (2001). "Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease". J. Biol. Chem. 275 (45): 35291–6. doi:10.1074/jbc.M000525200. PMID 10948187.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belaguli NS, Sepulveda JL, Nigam V; et al. (2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. 20 (20): 7550–8. PMID 11003651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morin S, Paradis P, Aries A, Nemer M (2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. PMID 11158291.CS1 maint: Multiple names: authors list (link)
• Crispino JD, Lodish MB, Thurberg BL; et al. (2001). "Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors". Genes Dev. 15 (7): 839–44. doi:10.1101/gad.875201. PMID 11297508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai YS, Markham BE (2001). "p300 Functions as a coactivator of transcription factor GATA-4". J. Biol. Chem. 276 (40): 37178–85. doi:10.1074/jbc.M103731200. PMID 11481322.
• Liang Q, Wiese RJ, Bueno OF; et al. (2001). "The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes". Mol. Cell. Biol. 21 (21): 7460–9. doi:10.1128/MCB.21.21.7460-7469.2001. PMID 11585926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GATA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.