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{{Infobox_gene}}
{{PBB_Controls
'''Fos-related antigen 1''' ('''FRA1''') is a [[protein]] that in humans is encoded by the ''FOSL1'' [[gene]].<ref name="pmid2107490">{{cite journal | vauthors = Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R | title = Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation | journal = Oncogene | volume = 5 | issue = 3 | pages = 249–55 | date = Mar 1990 | pmid = 2107490 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOSL1 FOS-like antigen 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8061| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = FOS-like antigen 1
| HGNCid = 13718
| Symbol = FOSL1
| AltSymbols =; FRA1; fra-1
| OMIM = 136515
| ECnumber = 
| Homologene = 3967
| MGIid = 107179
| GeneAtlas_image1 = PBB_GE_FOSL1_204420_at_tn.png
| GeneAtlas_image2 = PBB_GE_FOSL1_213250_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8061
    | Hs_Ensembl = ENSG00000175592
    | Hs_RefseqProtein = NP_005429
    | Hs_RefseqmRNA = NM_005438
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 65416268
    | Hs_GenLoc_end = 65424573
    | Hs_Uniprot = P15407
    | Mm_EntrezGene = 14283
    | Mm_Ensembl = ENSMUSG00000024912
    | Mm_RefseqmRNA = NM_010235
    | Mm_RefseqProtein = NP_034365
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5447698
    | Mm_GenLoc_end = 5455938
    | Mm_Uniprot = Q3UMA0
  }}
}}
'''FOS-like antigen 1''', also known as '''FOSL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL1 FOS-like antigen 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8061| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The Fos gene family consists of 4 members: [[c-Fos]], [[FOSB]], FOSL1, and [[FOSL2]]. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL1 FOS-like antigen 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8061| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
FOSL1 has been shown to [[Protein-protein interaction|interact]] with [[USF1 (human gene)]]<ref name=pmid9160889>{{cite journal | vauthors = Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H | title = Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity | journal = Oncogene | volume = 14 | issue = 17 | pages = 2091–8 | date = May 1997 | pmid = 9160889 | doi = 10.1038/sj.onc.1201046 }}</ref> and [[C-jun]].<ref name=pmid9160889/>
 
== See also ==
* [[AP-1 (transcription factor)]]
* [[AP-1 (transcription factor)]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Herdegen T, Leah JD | title = Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins | journal = Brain Research. Brain Research Reviews | volume = 28 | issue = 3 | pages = 370–490 | date = Dec 1998 | pmid = 9858769 | doi = 10.1016/S0165-0173(98)00018-6 }}
| citations =
* {{cite journal | vauthors = Reddy SP, Mossman BT | title = Role and regulation of activator protein-1 in toxicant-induced responses of the lung | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 283 | issue = 6 | pages = L1161-78 | date = Dec 2002 | pmid = 12424143 | doi = 10.1152/ajplung.00140.2002 }}
*{{cite journal | author=Herdegen T, Leah JD |title=Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. |journal=Brain Res. Brain Res. Rev. |volume=28 |issue= 3 |pages= 370-490 |year= 1999 |pmid= 9858769 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Reddy SP, Mossman BT |title=Role and regulation of activator protein-1 in toxicant-induced responses of the lung. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=283 |issue= 6 |pages= L1161-78 |year= 2002 |pmid= 12424143 |doi= 10.1152/ajplung.00140.2002 }}
* {{cite journal | vauthors = Tsuchiya H, Fujii M, Niki T, Tokuhara M, Matsui M, Seiki M | title = Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals | journal = Journal of Virology | volume = 67 | issue = 12 | pages = 7001–7 | date = Dec 1993 | pmid = 8230424 | pmc = 238160 | doi =  }}
*{{cite journal | author=Matsui M, Tokuhara M, Konuma Y, ''et al.'' |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249-55 |year= 1990 |pmid= 2107490 |doi= }}
* {{cite journal | vauthors = Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A | title = Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13 | journal = Genomics | volume = 18 | issue = 1 | pages = 165 | date = Oct 1993 | pmid = 8276409 | doi = 10.1006/geno.1993.1447 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
* {{cite journal | vauthors = Courseaux A, Grosgeorge J, Gaudray P, Pannett AA, Forbes SA, Williamson C, Bassett D, Thakker RV, Teh BT, Farnebo F, Shepherd J, Skogseid B, Larsson C, Giraud S, Zhang CX, Salandre J, Calender A | title = Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1) | journal = Genomics | volume = 37 | issue = 3 | pages = 354–65 | date = Nov 1996 | pmid = 8938448 | doi = 10.1006/geno.1996.0570 }}
*{{cite journal | author=Tsuchiya H, Fujii M, Niki T, ''et al.'' |title=Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. |journal=J. Virol. |volume=67 |issue= 12 |pages= 7001-7 |year= 1993 |pmid= 8230424 |doi= }}
* {{cite journal | vauthors = Arts J, Herr I, Lansink M, Angel P, Kooistra T | title = Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro | journal = Nucleic Acids Research | volume = 25 | issue = 2 | pages = 311–7 | date = Jan 1997 | pmid = 9016559 | pmc = 146448 | doi = 10.1093/nar/25.2.311 }}
*{{cite journal | author=Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A |title=Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13. |journal=Genomics |volume=18 |issue= 1 |pages= 165 |year= 1994 |pmid= 8276409 |doi= }}
* {{cite journal | vauthors = Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H | title = Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity | journal = Oncogene | volume = 14 | issue = 17 | pages = 2091–8 | date = May 1997 | pmid = 9160889 | doi = 10.1038/sj.onc.1201046 }}
*{{cite journal | author=Courseaux A, Grosgeorge J, Gaudray P, ''et al.'' |title=Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). |journal=Genomics |volume=37 |issue= 3 |pages= 354-65 |year= 1997 |pmid= 8938448 |doi= }}
* {{cite journal | vauthors = Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS | title = A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13 | journal = Genome Research | volume = 7 | issue = 8 | pages = 835–42 | date = Aug 1997 | pmid = 9267807 | pmc = 310665 | doi = 10.1101/gr.7.8.835 }}
*{{cite journal | author=Arts J, Herr I, Lansink M, ''et al.'' |title=Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 311-7 |year= 1997 |pmid= 9016559 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Pognonec P, Boulukos KE, Aperlo C, ''et al.'' |title=Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. |journal=Oncogene |volume=14 |issue= 17 |pages= 2091-8 |year= 1997 |pmid= 9160889 |doi= 10.1038/sj.onc.1201046 }}
* {{cite journal | vauthors = Puntschart A, Wey E, Jostarndt K, Vogt M, Wittwer M, Widmer HR, Hoppeler H, Billeter R | title = Expression of fos and jun genes in human skeletal muscle after exercise | journal = The American Journal of Physiology | volume = 274 | issue = 1 Pt 1 | pages = C129-37 | date = Jan 1998 | pmid = 9458721 | doi =  }}
*{{cite journal | author=Smith CM, Ma NS, Nowak NJ, ''et al.'' |title=A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. |journal=Genome Res. |volume=7 |issue= 8 |pages= 835-42 |year= 1997 |pmid= 9267807 |doi= }}
* {{cite journal | vauthors = Finzer P, Soto U, Delius H, Patzelt A, Coy JF, Poustka A, zur Hausen H, Rösl F | title = Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition | journal = Oncogene | volume = 19 | issue = 29 | pages = 3235–44 | date = Jul 2000 | pmid = 10918580 | doi = 10.1038/sj.onc.1203643 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Udalova IA, Kwiatkowski D | title = Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region | journal = Biochemical and Biophysical Research Communications | volume = 289 | issue = 1 | pages = 25–33 | date = Nov 2001 | pmid = 11708771 | doi = 10.1006/bbrc.2001.5929 }}
*{{cite journal | author=Puntschart A, Wey E, Jostarndt K, ''et al.'' |title=Expression of fos and jun genes in human skeletal muscle after exercise. |journal=Am. J. Physiol. |volume=274 |issue= 1 Pt 1 |pages= C129-37 |year= 1998 |pmid= 9458721 |doi= }}
* {{cite journal | vauthors = Jardine H, MacNee W, Donaldson K, Rahman I | title = Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21158–66 | date = Jun 2002 | pmid = 11912197 | doi = 10.1074/jbc.M112145200 }}
*{{cite journal | author=Finzer P, Soto U, Delius H, ''et al.'' |title=Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. |journal=Oncogene |volume=19 |issue= 29 |pages= 3235-44 |year= 2000 |pmid= 10918580 |doi= 10.1038/sj.onc.1203643 }}
* {{cite journal | vauthors = Wang HL, Wang J, Xiao SY, Haydon R, Stoiber D, He TC, Bissonnette M, Hart J | title = Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin | journal = International Journal of Cancer | volume = 101 | issue = 4 | pages = 301–10 | date = Oct 2002 | pmid = 12209953 | doi = 10.1002/ijc.10630 }}
*{{cite journal | author=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25-33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929 }}
* {{cite journal | vauthors = Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH | title = A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 485–96 | date = Feb 2003 | pmid = 12371906 | pmc = 1223099 | doi = 10.1042/BJ20020707 }}
*{{cite journal | author=Jardine H, MacNee W, Donaldson K, Rahman I |title=Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21158-66 |year= 2002 |pmid= 11912197 |doi= 10.1074/jbc.M112145200 }}
*{{cite journal | author=Wang HL, Wang J, Xiao SY, ''et al.'' |title=Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. |journal=Int. J. Cancer |volume=101 |issue= 4 |pages= 301-10 |year= 2002 |pmid= 12209953 |doi= 10.1002/ijc.10630 }}
*{{cite journal  | author=Bergman MR, Cheng S, Honbo N, ''et al.'' |title=A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 485-96 |year= 2003 |pmid= 12371906 |doi= 10.1042/BJ20020707 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|FOSL1+protein,+human}}
* {{MeshName|FOSL1+protein,+human}}
* {{FactorBook|FOSL1}}
{{NLM content}}
{{Transcription factors|g1}}


{{NLM content}}
{{protein-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-11-stub}}

Latest revision as of 21:57, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[1][2]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[2]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)[3] and C-jun.[3]

See also

References

  1. ↑ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490.
  2. ↑ 2.0 2.1 "Entrez Gene: FOSL1 FOS-like antigen 1".
  3. ↑ 3.0 3.1 Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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