Estrogen-related receptor gamma

Estrogen-related receptor gamma
PDB rendering based on 1kv6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kv6​, 1lo1​, 1s9p​, 1s9q​, 1tfc​, 1vjb​, 2ewp​, 2gp7​, 2gpo​, 2gpp​, 2gpu​, 2gpv​
Identifiers
Symbols	ESRRG ; DKFZp781L1617; ERR3; FLJ16023; KIAA0832; NR3B3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55581
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor which is encoded by the gene ESRRG (EStrogen Related Receptor Gamma).

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Eudy JD, Yao S, Weston MD; et al. (1998). "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41". Genomics. 50 (3): 382–4. doi:10.1006/geno.1998.5345. PMID 9676434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen F, Zhang Q, McDonald T; et al. (1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. PMID 10072763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hong H, Yang L, Stallcup MR (1999). "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3". J. Biol. Chem. 274 (32): 22618–26. PMID 10428842.CS1 maint: Multiple names: authors list (link)
• Heard DJ, Norby PL, Holloway J, Vissing H (2000). "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult". Mol. Endocrinol. 14 (3): 382–92. PMID 10707956.CS1 maint: Multiple names: authors list (link)
• Greschik H, Wurtz JM, Sanglier S; et al. (2002). "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3". Mol. Cell. 9 (2): 303–13. PMID 11864604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hentschke M, Süsens U, Borgmeyer U (2002). "Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding". Eur. J. Biochem. 269 (16): 4086–97. PMID 12180985.CS1 maint: Multiple names: authors list (link)
• Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochem. Biophys. Res. Commun. 299 (5): 872–9. PMID 12470660.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hentschke M, Schulze C, Süsens U, Borgmeyer U (2003). "Characterization of calmodulin binding to the orphan nuclear receptor Errgamma". Biol. Chem. 384 (3): 473–82. PMID 12715898.CS1 maint: Multiple names: authors list (link)
• Hentschke M, Borgmeyer U (2004). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma". Biochem. Biophys. Res. Commun. 312 (4): 975–82. PMID 14651967.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheung CP, Yu S, Wong KB; et al. (2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". J. Clin. Endocrinol. Metab. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu D, Zhang Z, Teng CT (2005). "Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element". J. Mol. Endocrinol. 34 (2): 473–87. doi:10.1677/jme.1.01586. PMID 15821111.CS1 maint: Multiple names: authors list (link)
• Gao M, Sun P, Wang J; et al. (2006). "Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma". Int. J. Gynecol. Cancer. 16 (2): 827–33. doi:10.1111/j.1525-1438.2006.00527.x. PMID 16681769.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Zuercher WJ, Consler TG; et al. (2007). "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation". J. Biol. Chem. 281 (49): 37773–81. doi:10.1074/jbc.M608410200. PMID 16990259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)