CREBL1: Difference between revisions

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{{Infobox_gene}}
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'''CAMP responsive element binding protein-like 1''', also known as '''CREBL1''', is a [[protein]] which in humans is encoded by the ''CREBL1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1388| accessdate = }}</ref><ref name="pmid11256944">{{cite journal | vauthors = Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K | title = Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response | journal = Biochem. J. | volume = 355 | issue = Pt 1 | pages = 19–28 |date=April 2001 | pmid = 11256944 | pmc = 1221707 | doi = 10.1042/0264-6021:3550019| url = http://www.biochemj.org/bj/355/0019/bj3550019.htm }}</ref>
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== Function ==
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene bears sequence similarity with the [[CREB|Creb]]/ATF subfamily of the [[BZIP domain|bZip]] superfamily of [[transcription factor]]s. It localizes to both the [[cytoplasm]] and the [[cell nucleus|nucleus]]. The gene localizes to the [[major histocompatibility complex]] (MHC) class III region on [[chromosome 6]].<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = CAMP responsive element binding protein-like 1
| HGNCid = 2349
| Symbol = CREBL1
| AltSymbols =; CREB-RP; FLJ10066; G13
| OMIM = 600984
| ECnumber = 
| Homologene = 31238
| MGIid = 105121
| GeneAtlas_image1 = PBB_GE_CREBL1_203168_at_tn.png
| GeneAtlas_image2 = PBB_GE_CREBL1_211611_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CREBL1_216208_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1388
    | Hs_Ensembl = ENSG00000168468
    | Hs_RefseqProtein = NP_004372
    | Hs_RefseqmRNA = NM_004381
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = c6_COX
    | Hs_GenLoc_start = 32161665
    | Hs_GenLoc_end = 32191727
    | Hs_Uniprot = Q99941
    | Mm_EntrezGene = 12915
    | Mm_Ensembl = ENSMUSG00000015461
    | Mm_RefseqmRNA = XM_001001528
    | Mm_RefseqProtein = XP_001001528
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34255202
    | Mm_GenLoc_end = 34263130
    | Mm_Uniprot = Q3TXP5
  }}
}}
'''CAMP responsive element binding protein-like 1''', also known as '''CREBL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1388| accessdate = }}</ref>


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== References ==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1388| accessdate = }}</ref>
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bristow J, Tee MK, Gitelman SE, ''et al.'' |title=Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. |journal=J. Cell Biol. |volume=122 |issue= 1 |pages= 265-78 |year= 1993 |pmid= 7686164 |doi=  }}
*{{cite journal  | vauthors=Bristow J, Tee MK, Gitelman SE |title=Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. |journal=J. Cell Biol. |volume=122 |issue= 1 |pages= 265–78 |year= 1993 |pmid= 7686164 |doi=10.1083/jcb.122.1.265  | pmc=2119596 |display-authors=etal}}
*{{cite journal  | author=Min J, Shukla H, Kozono H, ''et al.'' |title=A novel Creb family gene telomeric of HLA-DRA in the HLA complex. |journal=Genomics |volume=30 |issue= 2 |pages= 149-56 |year= 1996 |pmid= 8586413 |doi= 10.1006/geno.1995.9891 }}
*{{cite journal  | vauthors=Min J, Shukla H, Kozono H |title=A novel Creb family gene telomeric of HLA-DRA in the HLA complex. |journal=Genomics |volume=30 |issue= 2 |pages= 149–56 |year= 1996 |pmid= 8586413 |doi= 10.1006/geno.1995.9891 |display-authors=etal}}
*{{cite journal  | author=Khanna A, Campbell RD |title=The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. |journal=Biochem. J. |volume=319 ( Pt 1) |issue=  |pages= 81-9 |year= 1996 |pmid= 8870652 |doi=  }}
*{{cite journal  | vauthors=Khanna A, Campbell RD |title=The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. | series=319 |journal=Biochem. J. |volume=( Pt 1) |issue=  |pages= 81–9 |year= 1996 |pmid= 8870652 |doi= | pmc=1217738 }}
*{{cite journal  | author=Speek M, Barry F, Miller WL |title=Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. |journal=Hum. Mol. Genet. |volume=5 |issue= 11 |pages= 1749-58 |year= 1997 |pmid= 8923003 |doi=  }}
*{{cite journal  | vauthors=Speek M, Barry F, Miller WL |title=Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. |journal=Hum. Mol. Genet. |volume=5 |issue= 11 |pages= 1749–58 |year= 1997 |pmid= 8923003 |doi=10.1093/hmg/5.11.1749 }}
*{{cite journal  | author=Swanson DJ, Adachi M, Lewis EJ |title=The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2911-23 |year= 2000 |pmid= 10644760 |doi=  }}
*{{cite journal  | vauthors=Swanson DJ, Adachi M, Lewis EJ |title=The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2911–23 |year= 2000 |pmid= 10644760 |doi=10.1074/jbc.275.4.2911 }}
*{{cite journal  | author=Yoshida H, Okada T, Haze K, ''et al.'' |title=Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1239-48 |year= 2001 |pmid= 11158310 |doi= 10.1128/MCB.21.4.1239-1248.2001 }}
*{{cite journal  | vauthors=Yoshida H, Okada T, Haze K |title=Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1239–48 |year= 2001 |pmid= 11158310 |doi= 10.1128/MCB.21.4.1239-1248.2001 | pmc=99577 |display-authors=etal}}
*{{cite journal  | author=Ye J, Rawson RB, Komuro R, ''et al.'' |title=ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1355-64 |year= 2001 |pmid= 11163209 |doi=  }}
*{{cite journal  | vauthors=Ye J, Rawson RB, Komuro R |title=ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1355–64 |year= 2001 |pmid= 11163209 |doi=10.1016/S1097-2765(00)00133-7 |display-authors=etal}}
*{{cite journal  | author=Haze K, Okada T, Yoshida H, ''et al.'' |title=Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. |journal=Biochem. J. |volume=355 |issue= Pt 1 |pages= 19-28 |year= 2001 |pmid= 11256944 |doi=  }}
*{{cite journal  | vauthors=Haze K, Okada T, Yoshida H |title=Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. |journal=Biochem. J. |volume=355 |issue= Pt 1 |pages= 19–28 |year= 2001 |pmid= 11256944 |doi=10.1042/0264-6021:3550019  | pmc=1221707 |display-authors=etal}}
*{{cite journal  | author=Tong WY, Nagano-Fujii M, Hidajat R, ''et al.'' |title=Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 366-72 |year= 2003 |pmid= 12445808 |doi=  }}
*{{cite journal  | vauthors=Tong WY, Nagano-Fujii M, Hidajat R |title=Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 366–72 |year= 2003 |pmid= 12445808 |doi=10.1016/S0006-291X(02)02638-4 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Okada T, Haze K, Nadanaka S, ''et al.'' |title=A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31024-32 |year= 2003 |pmid= 12782636 |doi= 10.1074/jbc.M300923200 }}
*{{cite journal  | vauthors=Okada T, Haze K, Nadanaka S |title=A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31024–32 |year= 2003 |pmid= 12782636 |doi= 10.1074/jbc.M300923200 |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal  | vauthors=Xie T, Rowen L, Aguado B |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CREBL1+protein,+human}}
* {{MeshName|CREBL1+protein,+human}}
* {{UCSC gene info|ATF6B}}
{{NLM content}}
{{Transcription factors|g1}}
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[[Category:Transcription factors]]




{{protein-stub}}
{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 10:02, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.[1][2]

Function

The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1".
  2. ↑ Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K (April 2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28. doi:10.1042/0264-6021:3550019. PMC 1221707. PMID 11256944.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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