CNBP

CCHC-type zinc finger, nucleic acid binding protein
Identifiers
Symbols	CNBP ; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2567
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CCHC-type zinc finger, nucleic acid binding protein, also known as CNBP, is a human gene.

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM]

Further reading

• Lusis AJ, Rajavashisth TB, Klisak I; et al. (1991). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics. 8 (2): 411–4. PMID 2249857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajavashisth TB, Taylor AK, Andalibi A; et al. (1989). "Identification of a zinc finger protein that binds to the sterol regulatory element". Science. 245 (4918): 640–3. PMID 2562787.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flink IL, Morkin E (1995). "Organization of the gene encoding cellular nucleic acid-binding protein". Gene. 163 (2): 279–82. PMID 7590281.
• Warden CH, Krisans SK, Purcell-Huynh D; et al. (1995). "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing". Genomics. 24 (1): 14–9. doi:10.1006/geno.1994.1576. PMID 7896269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ricker K, Grimm T, Koch MC; et al. (1999). "Linkage of proximal myotonic myopathy to chromosome 3q". Neurology. 52 (1): 170–1. PMID 9921867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liquori CL, Ricker K, Moseley ML; et al. (2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science. 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McGrath CF, Buckman JS, Gagliardi TD; et al. (2003). "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein". J. Virol. 77 (15): 8524–31. PMID 12857921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vallo L, Bonifazi E, Borgiani P; et al. (2005). "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population". Mol. Cell. Probes. 19 (1): 71–4. doi:10.1016/j.mcp.2004.09.003. PMID 15652222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Botta A, Caldarola S, Vallo L; et al. (2006). "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2)". Biochim. Biophys. Acta. 1762 (3): 329–34. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Margolis JM, Schoser BG, Moseley ML; et al. (2006). "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression". Hum. Mol. Genet. 15 (11): 1808–15. doi:10.1093/hmg/ddl103. PMID 16624843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toth C, Dunham C, Suchowersky O; et al. (2007). "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2". Muscle Nerve. 35 (2): 259–64. doi:10.1002/mus.20685. PMID 17068784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerbasi VR, Link AJ (2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation". Mol. Cell Proteomics. 6 (6): 1049–58. doi:10.1074/mcp.M600384-MCP200. PMID 17327219.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ZNF9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.