CNBP: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Cellular nucleic acid-binding protein''' is a [[protein]] that in humans is encoded by the ''CNBP'' [[gene]].<ref name="pmid2249857">{{cite journal | vauthors = Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS | title = Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24 | journal = Genomics | volume = 8 | issue = 2 | pages = 411–4 | date = Oct 1990 | pmid = 2249857 | pmc =  | doi = 10.1016/0888-7543(90)90303-C }}</ref><ref name="pmid11486088">{{cite journal | vauthors = Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP | title = Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9 | journal = Science | volume = 293 | issue = 5531 | pages = 864–7 | date = Aug 2001 | pmid = 11486088 | pmc = | doi = 10.1126/science.1062125 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7555| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CCHC-type zinc finger, nucleic acid binding protein
| HGNCid = 13164
| Symbol = CNBP
| AltSymbols =; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
| OMIM = 116955
| ECnumber = 
| Homologene = 2567
| MGIid = 88431
| GeneAtlas_image1 = PBB_GE_CNBP_206158_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006695 |text = cholesterol biosynthetic process}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7555
    | Hs_Ensembl = ENSG00000169714
    | Hs_RefseqProtein = NP_003409
    | Hs_RefseqmRNA = NM_003418
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 130371020
    | Hs_GenLoc_end = 130385432
    | Hs_Uniprot = P62633
    | Mm_EntrezGene = 12785
    | Mm_Ensembl = ENSMUSG00000030057
    | Mm_RefseqmRNA = NM_013493
    | Mm_RefseqProtein = NP_038521
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 87808723
    | Mm_GenLoc_end = 87816711
    | Mm_Uniprot = Q3U5V2
  }}
}}
'''CCHC-type zinc finger, nucleic acid binding protein''', also known as '''CNBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7555| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in [[myotonic dystrophy]] type 2 (MIM 602668).[supplied by OMIM]<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in [[myotonic dystrophy]] type 2 (MIM 602668).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7555| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rajavashisth TB, Taylor AK, Andalibi A, Svenson KL, Lusis AJ | title = Identification of a zinc finger protein that binds to the sterol regulatory element | journal = Science | volume = 245 | issue = 4918 | pages = 640–3 | date = Aug 1989 | pmid = 2562787 | doi = 10.1126/science.2562787 }}
| citations =
* {{cite journal | vauthors = Flink IL, Morkin E | title = Organization of the gene encoding cellular nucleic acid-binding protein | journal = Gene | volume = 163 | issue = 2 | pages = 279–82 | date = Oct 1995 | pmid = 7590281 | doi = 10.1016/0378-1119(95)00421-2 }}
*{{cite journal  | author=Lusis AJ, Rajavashisth TB, Klisak I, ''et al.'' |title=Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24. |journal=Genomics |volume=8 |issue= 2 |pages= 411-4 |year= 1991 |pmid= 2249857 |doi=  }}
* {{cite journal | vauthors = Warden CH, Krisans SK, Purcell-Huynh D, Leete LM, Daluiski A, Diep A, Taylor BA, Lusis AJ | title = Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing | journal = Genomics | volume = 24 | issue = 1 | pages = 14–9 | date = Nov 1994 | pmid = 7896269 | doi = 10.1006/geno.1994.1576 }}
*{{cite journal | author=Rajavashisth TB, Taylor AK, Andalibi A, ''et al.'' |title=Identification of a zinc finger protein that binds to the sterol regulatory element. |journal=Science |volume=245 |issue= 4918 |pages= 640-3 |year= 1989 |pmid= 2562787 |doi= }}
* {{cite journal | vauthors = Ricker K, Grimm T, Koch MC, Schneider C, Kress W, Reimers CD, Schulte-Mattler W, Mueller-Myhsok B, Toyka KV, Mueller CR | title = Linkage of proximal myotonic myopathy to chromosome 3q | journal = Neurology | volume = 52 | issue = 1 | pages = 170–1 | date = Jan 1999 | pmid = 9921867 | doi = 10.1212/wnl.52.1.170 }}
*{{cite journal | author=Flink IL, Morkin E |title=Organization of the gene encoding cellular nucleic acid-binding protein. |journal=Gene |volume=163 |issue= 2 |pages= 279-82 |year= 1995 |pmid= 7590281 |doi= }}
* {{cite journal | vauthors = McGrath CF, Buckman JS, Gagliardi TD, Bosche WJ, Coren LV, Gorelick RJ | title = Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein | journal = Journal of Virology | volume = 77 | issue = 15 | pages = 8524–31 | date = Aug 2003 | pmid = 12857921 | pmc = 165261 | doi = 10.1128/JVI.77.15.8524-8531.2003 }}
*{{cite journal | author=Warden CH, Krisans SK, Purcell-Huynh D, ''et al.'' |title=Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. |journal=Genomics |volume=24 |issue= 1 |pages= 14-9 |year= 1995 |pmid= 7896269 |doi= 10.1006/geno.1994.1576 }}
* {{cite journal | vauthors = Vallo L, Bonifazi E, Borgiani P, Novelli G, Botta A | title = Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population | journal = Molecular and Cellular Probes | volume = 19 | issue = 1 | pages = 71–4 | date = Feb 2005 | pmid = 15652222 | doi = 10.1016/j.mcp.2004.09.003 }}
*{{cite journal | author=Ricker K, Grimm T, Koch MC, ''et al.'' |title=Linkage of proximal myotonic myopathy to chromosome 3q. |journal=Neurology |volume=52 |issue= 1 |pages= 170-1 |year= 1999 |pmid= 9921867 |doi=  }}
* {{cite journal | vauthors = Botta A, Caldarola S, Vallo L, Bonifazi E, Fruci D, Gullotta F, Massa R, Novelli G, Loreni F | title = Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2) | journal = Biochimica et Biophysica Acta | volume = 1762 | issue = 3 | pages = 329–34 | date = Mar 2006 | pmid = 16376058 | doi = 10.1016/j.bbadis.2005.11.004 }}
*{{cite journal  | author=Liquori CL, Ricker K, Moseley ML, ''et al.'' |title=Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. |journal=Science |volume=293 |issue= 5531 |pages= 864-7 |year= 2001 |pmid= 11486088 |doi= 10.1126/science.1062125 }}
* {{cite journal | vauthors = Margolis JM, Schoser BG, Moseley ML, Day JW, Ranum LP | title = DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression | journal = Human Molecular Genetics | volume = 15 | issue = 11 | pages = 1808–15 | date = Jun 2006 | pmid = 16624843 | doi = 10.1093/hmg/ddl103 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Toth C, Dunham C, Suchowersky O, Parboosingh J, Brownell K | title = Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2 | journal = Muscle & Nerve | volume = 35 | issue = 2 | pages = 259–64 | date = Feb 2007 | pmid = 17068784 | doi = 10.1002/mus.20685 }}
*{{cite journal | author=McGrath CF, Buckman JS, Gagliardi TD, ''et al.'' |title=Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein. |journal=J. Virol. |volume=77 |issue= 15 |pages= 8524-31 |year= 2003 |pmid= 12857921 |doi= }}
* {{cite journal | vauthors = Gerbasi VR, Link AJ | title = The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 6 | pages = 1049–58 | date = Jun 2007 | pmid = 17327219 | doi = 10.1074/mcp.M600384-MCP200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Vallo L, Bonifazi E, Borgiani P, ''et al.'' |title=Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population. |journal=Mol. Cell. Probes |volume=19 |issue= 1 |pages= 71-4 |year= 2005 |pmid= 15652222 |doi= 10.1016/j.mcp.2004.09.003 }}
*{{cite journal | author=Botta A, Caldarola S, Vallo L, ''et al.'' |title=Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2). |journal=Biochim. Biophys. Acta |volume=1762 |issue= 3 |pages= 329-34 |year= 2006 |pmid= 16376058 |doi= 10.1016/j.bbadis.2005.11.004 }}
*{{cite journal | author=Margolis JM, Schoser BG, Moseley ML, ''et al.'' |title=DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression. |journal=Hum. Mol. Genet. |volume=15 |issue= 11 |pages= 1808-15 |year= 2006 |pmid= 16624843 |doi= 10.1093/hmg/ddl103 }}
*{{cite journal | author=Toth C, Dunham C, Suchowersky O, ''et al.'' |title=Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2. |journal=Muscle Nerve |volume=35 |issue= 2 |pages= 259-64 |year= 2007 |pmid= 17068784 |doi= 10.1002/mus.20685 }}
*{{cite journal | author=Gerbasi VR, Link AJ |title=The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation. |journal=Mol. Cell Proteomics |volume=6 |issue= 6 |pages= 1049-58 |year= 2007 |pmid= 17327219 |doi= 10.1074/mcp.M600384-MCP200 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=myotonic-d2  GeneReviews/NCBI/NIH/UW entry on Myotonic Dystrophy Type 2]
* {{MeshName|ZNF9+protein,+human}}
* {{MeshName|ZNF9+protein,+human}}
* {{UCSC gene info|CNBP}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g2}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-3-stub}}

Latest revision as of 09:51, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.[1][2][3]

Function

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM][3]

References

  1. ↑ Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS (Oct 1990). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics. 8 (2): 411–4. doi:10.1016/0888-7543(90)90303-C. PMID 2249857.
  2. ↑ Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP (Aug 2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science. 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088.
  3. ↑ 3.0 3.1 "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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