ATF3

Activating transcription factor 3
Identifiers
Symbols	ATF3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1265
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Activating transcription factor 3, also known as ATF3, is a human gene.

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

See also

• Activating transcription factor

Further reading

• Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. PMID 2516827.CS1 maint: Multiple names: authors list (link)
• Chen BP, Liang G, Whelan J, Hai T (1994). "ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms". J. Biol. Chem. 269 (22): 15819–26. PMID 7515060.CS1 maint: Multiple names: authors list (link)
• Kaszubska W, Hooft van Huijsduijnen R, Ghersa P; et al. (1993). "Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines". Mol. Cell. Biol. 13 (11): 7180–90. PMID 7692236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chu HM, Tan Y, Kobierski LA; et al. (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression". Mol. Endocrinol. 8 (1): 59–68. PMID 8152431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liang G, Wolfgang CD, Chen BP; et al. (1996). "ATF3 gene. Genomic organization, promoter, and regulation". J. Biol. Chem. 271 (3): 1695–701. PMID 8576171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen BP, Wolfgang CD, Hai T (1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. 16 (3): 1157–68. PMID 8622660.CS1 maint: Multiple names: authors list (link)
• Hagmeyer BM, Duyndam MC, Angel P; et al. (1996). "Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3". Oncogene. 12 (5): 1025–32. PMID 8649793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allan AL, Albanese C, Pestell RG, LaMarre J (2001). "Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes". J. Biol. Chem. 276 (29): 27272–80. doi:10.1074/jbc.M103196200. PMID 11375399.CS1 maint: Multiple names: authors list (link)
• Zhang C, Kawauchi J, Adachi MT; et al. (2002). "Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine". Biochem. Biophys. Res. Commun. 289 (3): 718–24. doi:10.1006/bbrc.2001.6044. PMID 11726207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan C, Wang H, Boyd DD (2002). "ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter". J. Biol. Chem. 277 (13): 10804–12. doi:10.1074/jbc.M112069200. PMID 11792711.CS1 maint: Multiple names: authors list (link)
• Shaheduzzaman S, Krishnan V, Petrovic A; et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". J. Biomed. Sci. 9 (1): 82–96. PMID 11810028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto Y, Zhang C, Kawauchi J; et al. (2002). "An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli". Nucleic Acids Res. 30 (11): 2398–406. PMID 12034827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawauchi J, Zhang C, Nobori K; et al. (2002). "Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription". J. Biol. Chem. 277 (41): 39025–34. doi:10.1074/jbc.M202974200. PMID 12161427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang C, Gao C, Kawauchi J; et al. (2002). "Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53". Biochem. Biophys. Res. Commun. 297 (5): 1302–10. PMID 12372430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan F, Jin S, Amundson SA; et al. (2002). "ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth". Oncogene. 21 (49): 7488–96. doi:10.1038/sj.onc.1205896. PMID 12386811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nobori K, Ito H, Tamamori-Adachi M; et al. (2003). "ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3". J. Mol. Cell. Cardiol. 34 (10): 1387–97. PMID 12392999.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang Y, Chen CR, Massagué J (2003). "A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells". Mol. Cell. 11 (4): 915–26. PMID 12718878.CS1 maint: Multiple names: authors list (link)
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.
• Kool J, Hamdi M, Cornelissen-Steijger P; et al. (2003). "Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2". Oncogene. 22 (27): 4235–42. doi:10.1038/sj.onc.1206611. PMID 12833146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ATF3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.