MXD4: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Max-interacting transcriptional repressor MAD4''' is a [[protein]] that in humans is encoded by the ''MXD4'' [[gene]].<ref name="pmid8521822">{{cite journal |vauthors=Hurlin PJ, Queva C, Koskinen PJ, Steingrimsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN | title = Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation | journal = EMBO J | volume = 14 | issue = 22 | pages = 5646–59 |date=Jan 1996 | pmid = 8521822 | pmc = 394680 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MXD4 MAX dimerization protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10608| accessdate = }}</ref>
'''Max-interacting transcriptional repressor MAD4''' is a [[protein]] that in humans is encoded by the ''MXD4'' [[gene]].<ref name="pmid8521822">{{cite journal | vauthors = Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN | title = Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation | journal = The EMBO Journal | volume = 14 | issue = 22 | pages = 5646–59 | date = November 1995 | pmid = 8521822 | pmc = 394680 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MXD4 MAX dimerization protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10608| accessdate = }}</ref>


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.<ref name="entrez">{{cite web | title = Entrez Gene: MXD4 MAX dimerization protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10608| accessdate = }}</ref>
}}


==References==
This gene is a member of the [[MADS-box|MAD]] gene family . The MAD genes encode basic helix-loop-helix-[[leucine zipper]] proteins that heterodimerize with [[MAX (gene)|MAX]] protein, forming a [[Repressor|transcriptional repression]] complex. The MAD proteins compete for MAX binding with MYC, which [[heterodimer]]izes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.<ref name="entrez">{{cite web | title = Entrez Gene: MXD4 MAX dimerization protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10608| accessdate = }}</ref>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
| citations =
* {{cite journal | vauthors = Marcotte R, Chen JM, Huard S, Wang E | title = c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts | journal = Journal of Cellular Biochemistry | volume = 96 | issue = 5 | pages = 1071–85 | date = December 2005 | pmid = 16167342 | doi = 10.1002/jcb.20503 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Pope SN, Lee IR | title = Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin | journal = The Journal of Steroid Biochemistry and Molecular Biology | volume = 94 | issue = 1–3 | pages = 203–8 | date = February 2005 | pmid = 15862967 | doi = 10.1016/j.jsbmb.2005.01.007 }}
*{{cite journal |vauthors=Marcotte R, Chen JM, Huard S, Wang E |title=c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. |journal=J. Cell. Biochem. |volume=96 |issue= 5 |pages= 1071–85 |year= 2006 |pmid= 16167342 |doi= 10.1002/jcb.20503 }}
* {{cite journal | vauthors = Jiang DJ, Yu HX, Hexige SY, Guo ZK, Wang X, Ma LJ, Chen Z, Zhao SY, Yu L | title = Human liver specific transcriptional factor TCP10L binds to MAD4 | journal = Journal of Biochemistry and Molecular Biology | volume = 37 | issue = 4 | pages = 402–7 | date = July 2004 | pmid = 15469726 | doi = 10.5483/bmbrep.2004.37.4.402 }}
*{{cite journal |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
* {{cite journal | vauthors = Kime L, Wright SC | title = Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc | journal = The Biochemical Journal | volume = 370 | issue = Pt 1 | pages = 291–8 | date = February 2003 | pmid = 12418961 | pmc = 1223147 | doi = 10.1042/BJ20021679 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
* {{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = March 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
* {{cite journal | vauthors = Billin AN, Eilers AL, Queva C, Ayer DE | title = Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36344–50 | date = December 1999 | pmid = 10593926 | doi = 10.1074/jbc.274.51.36344 }}
*{{cite journal  |vauthors=Jiang DJ, Yu HX, Hexige SY, etal |title=Human liver specific transcriptional factor [[TCP10L]] binds to MAD4. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 4 |pages= 402–7 |year= 2004 |pmid= 15469726 |doi= 10.5483/bmbrep.2004.37.4.402}}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Kime L, Wright SC |title=Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. |journal=Biochem. J. |volume=370 |issue= Pt 1 |pages= 291–8 |year= 2003 |pmid= 12418961 |doi= 10.1042/BJ20021679 | pmc=1223147 }}
*{{cite journal   |vauthors=Cairo S, Merla G, Urbinati F, etal |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617–27 |year= 2001 |pmid= 11230181 |doi=10.1093/hmg/10.6.617 }}
*{{cite journal |vauthors=Billin AN, Eilers AL, Queva C, Ayer DE |title=Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36344–50 |year= 2000 |pmid= 10593926 |doi=10.1074/jbc.274.51.36344 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{Transcription factors|g1}}
{{Transcription factors|g1}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]


{{gene-4-stub}}
{{gene-4-stub}}

Revision as of 13:16, 2 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[1][2]

Function

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[2]

References

  1. ↑ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal. 14 (22): 5646–59. PMC 394680. PMID 8521822.
  2. ↑ 2.0 2.1 "Entrez Gene: MXD4 MAX dimerization protein 4".

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Marcotte R, Chen JM, Huard S, Wang E (December 2005). "c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts". Journal of Cellular Biochemistry. 96 (5): 1071–85. doi:10.1002/jcb.20503. PMID 16167342.
  • Pope SN, Lee IR (February 2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
  • Jiang DJ, Yu HX, Hexige SY, Guo ZK, Wang X, Ma LJ, Chen Z, Zhao SY, Yu L (July 2004). "Human liver specific transcriptional factor TCP10L binds to MAD4". Journal of Biochemistry and Molecular Biology. 37 (4): 402–7. doi:10.5483/bmbrep.2004.37.4.402. PMID 15469726.
  • Kime L, Wright SC (February 2003). "Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc". The Biochemical Journal. 370 (Pt 1): 291–8. doi:10.1042/BJ20021679. PMC 1223147. PMID 12418961.
  • Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
  • Billin AN, Eilers AL, Queva C, Ayer DE (December 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". The Journal of Biological Chemistry. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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