REL: Difference between revisions
Jump to navigation
Jump to search
(Reverted 1 good faith edit by Markgomez using STiki) |
imported>QYYZ mNo edit summary |
||
| Line 1: | Line 1: | ||
{{ | {{for other uses|REL (disambiguation)}} | ||
{{Infobox_gene}} | {{Infobox_gene}} | ||
The '''proto-oncogene c-Rel''' is a [[protein]] that in humans is encoded by the ''REL'' [[gene]].<ref name="pmid1577270">{{cite journal | vauthors = Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA | title = I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity | journal = Genes Dev | volume = 6 | issue = 5 | pages = 745–60 |date=Jun 1992 | pmid = 1577270 | pmc = | doi =10.1101/gad.6.5.745 }}</ref> The c-Rel protein is a member of the [[NF-κB]] family of [[transcription factor]]s and contains a Rel homology domain ([[Rel homology domain|RHD]]) at its [[N-terminus]] and two [[C-terminal]] transactivation domains. c-Rel has an important role in [[B cell|B-cell]] survival and proliferation. The REL gene is amplified or mutated in several human [[B-cell lymphoma]]s, including [[diffuse large B-cell lymphoma]] and [[Hodgkin's lymphoma]].<ref name="pmid14755244">{{cite journal | vauthors = Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT | title = The c-Rel transcription factor and B-cell proliferation: a deal with the devil | journal = Oncogene | volume = 23 | issue = 13 | pages = 2275–86 |date=March 2004 | pmid = 14755244 | doi = 10.1038/sj.onc.1207410 }}</ref> | The '''proto-oncogene c-Rel''' is a [[protein]] that in humans is encoded by the ''REL'' [[gene]].<ref name="pmid1577270">{{cite journal | vauthors = Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA | title = I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity | journal = Genes Dev | volume = 6 | issue = 5 | pages = 745–60 |date=Jun 1992 | pmid = 1577270 | pmc = | doi =10.1101/gad.6.5.745 }}</ref> The c-Rel protein is a member of the [[NF-κB]] family of [[transcription factor]]s and contains a Rel homology domain ([[Rel homology domain|RHD]]) at its [[N-terminus]] and two [[C-terminal]] transactivation domains. c-Rel has an important role in [[B cell|B-cell]] survival and proliferation. The REL gene is amplified or mutated in several human [[B-cell lymphoma]]s, including [[diffuse large B-cell lymphoma]] and [[Hodgkin's lymphoma]].<ref name="pmid14755244">{{cite journal | vauthors = Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT | title = The c-Rel transcription factor and B-cell proliferation: a deal with the devil | journal = Oncogene | volume = 23 | issue = 13 | pages = 2275–86 |date=March 2004 | pmid = 14755244 | doi = 10.1038/sj.onc.1207410 }}</ref> | ||
Latest revision as of 21:36, 9 May 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[1] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[2]
References
- ↑ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
- ↑ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. doi:10.1038/sj.onc.1207410. PMID 14755244.
Further reading
- Rayet B, Gélinas C (2000). "Aberrant rel/nfkb genes and activity in human cancer". Oncogene. 18 (49): 6938–47. doi:10.1038/sj.onc.1203221. PMID 10602468.
- Kunsch C, Ruben SM, Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation". Mol. Cell. Biol. 12 (10): 4412–21. PMC 360365. PMID 1406630.
- Neumann M, Tsapos K, Scheppler JA, et al. (1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene. 7 (11): 2095–104. PMID 1437141.
- Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro". Oncogene. 7 (3): 567–72. PMID 1549370.
- Kumar S, Rabson AB, Gélinas C (1992). "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein". Mol. Cell. Biol. 12 (7): 3094–106. PMC 364524. PMID 1620118.
- Lu D, Thompson JD, Gorski GK, et al. (1991). "Alterations at the rel locus in human lymphoma". Oncogene. 6 (7): 1235–41. PMID 1650444.
- Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. 66 (1): 244–50. PMC 238281. PMID 1727488.
- Hansen SK, Nerlov C, Zabel U, et al. (1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene". EMBO J. 11 (1): 205–13. PMC 556441. PMID 1740106.
- Davis N, Ghosh S, Simmons DL, et al. (1991). "Rel-associated pp40: an inhibitor of the rel family of transcription factors". Science. 253 (5025): 1268–71. doi:10.1126/science.1891714. PMID 1891714.
- Lim MY, Davis N, Zhang JY, Bose HR (1990). "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70". Virology. 175 (1): 149–60. doi:10.1016/0042-6822(90)90195-W. PMID 2155506.
- Brownell E, Mittereder N, Rice NR (1989). "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon". Oncogene. 4 (7): 935–42. PMID 2666912.
- Brownell E, O'Brien SJ, Nash WG, Rice N (1986). "Genetic characterization of human c-rel sequences". Mol. Cell. Biol. 5 (10): 2826–31. PMC 367021. PMID 3016517.
- Brownell E, Kozak CA, Fowle JR, et al. (1986). "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat". Am. J. Hum. Genet. 39 (2): 194–202. PMC 1683919. PMID 3529946.
- John S, Reeves RB, Lin JX, et al. (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins". Mol. Cell. Biol. 15 (3): 1786–96. doi:10.1128/mcb.15.3.1786. PMC 230403. PMID 7862168.
- Xu X, Gélinas C (1995). "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells". Virology. 207 (2): 362–8. doi:10.1006/viro.1995.1095. PMID 7886940.
- Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers". J. Biol. Chem. 269 (42): 26363–7. PMID 7929355.
- Sif S, Gilmore TD (1994). "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1". J. Virol. 68 (11): 7131–8. PMC 237152. PMID 7933095.
- Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription". Mol. Cell. Biol. 14 (4): 2593–603. doi:10.1128/mcb.14.4.2593. PMC 358627. PMID 8139561.
- Beg AA, Baldwin AS (1994). "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor". Oncogene. 9 (5): 1487–92. PMID 8152812.
External links
- Genes,+rel at the US National Library of Medicine Medical Subject Headings (MeSH)
 | This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |