JunD

Jun D proto-oncogene
Identifiers
Symbol(s)	JUND;
External IDs	OMIM: 165162 MGI: 96648 Homologene: 3910
Gene ontology Molecular Function: • transcription factor activity • RNA polymerase II transcription factor activity • sequence-specific DNA binding • protein dimerization activity Cellular Component: • chromatin • nucleus Biological Process: • transcription • regulation of transcription from RNA polymerase II promoter
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3727	16478
Ensembl	ENSG00000130522	na
Uniprot	P17535	na
Refseq	NM_005354 (mRNA) NP_005345 (protein)	NM_010592 (mRNA) NP_034722 (protein)
Location	Chr 19: 18.25 - 18.25 Mb	na
Pubmed search	[1]	[2]

Jun D proto-oncogene, also known as JUND, is a human gene.

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.

See also

• AP-1 (transcription factor)

Further reading

• Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477-9. PMID 1899335.
• Berger I, Shaul Y (1991). "Structure and function of human jun-D.". Oncogene 6 (4): 561-6. PMID 1903194.
• Nomura N, Ide M, Sasamoto S, et al. (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.". Nucleic Acids Res. 18 (10): 3047-8. PMID 2112242.
• Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 ( Pt 3): 967-74. PMID 7848298.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
• Chu HM, Tan Y, Kobierski LA, et al. (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.". Mol. Endocrinol. 8 (1): 59-68. PMID 8152431.
• Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133-45. PMID 8432525.
• Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255-65. PMID 8570175.
• Claret FX, Hibi M, Dhut S, et al. (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.". Nature 383 (6599): 453-7. doi:10.1038/383453a0. PMID 8837781.
• Kallunki T, Deng T, Hibi M, Karin M (1997). "c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.". Cell 87 (5): 929-39. PMID 8945519.
• Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094-102. PMID 9154808.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
• Labudova O, Krapfenbauer K, Moenkemann H, et al. (1998). "Decreased transcription factor junD in brains of patients with Down syndrome.". Neurosci. Lett. 252 (3): 159-62. PMID 9739985.
• Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145-56. doi:10.1038/sj.onc.1202237. PMID 9872330.
• Agarwal SK, Guru SC, Heppner C, et al. (1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.". Cell 96 (1): 143-52. PMID 9989505.
• Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844-9. PMID 10220381.
• Gobl AE, Berg M, Lopez-Egido JR, et al. (1999). "Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism.". Biochim. Biophys. Acta 1447 (1): 51-6. PMID 10500243.
• Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.". Mol. Cell. Biol. 19 (11): 7589-99. PMID 10523647.
• Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78-90. PMID 10713367.
• Sharma SC, Richards JS (2000). "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.". J. Biol. Chem. 275 (43): 33718-28. doi:10.1074/jbc.M003555200. PMID 10934195.

External links

• MeSH JUND+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Gene-19-stub