Ramipril drug interactions

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Drug interactions


Antacids

Capsaicin

Digoxin

Diuretics

Indomethacin, salicylates (e.g, aspirin)

Lithium

Loop diuretics

Phenothiazines

Potassium supplements, potassium-sparing diuretics

Laboratory Test Interactions




Antacids

Ramipril bioavailability may be decreased. Separate administration times by 1 to 2 h.

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Capsaicin

May exacerbate cough.

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Digoxin

Increased or decreased digoxin levels.

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Diuretics

Increased risk of hypotension.

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Indomethacin, salicylates (e.g, aspirin)

May reduce hypotensive effects, especially in low-renin or volume-dependent hypertensive patients.

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Lithium

May cause increased lithium levels and symptoms of lithium toxicity.

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Loop diuretics

Effects of loop diuretics may be decreased.

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Phenothiazines

Enhanced hypotensive effects.

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Potassium supplements, potassium-sparing diuretics

May cause increased potassium (serum) levels.

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Laboratory Test Interactions

False elevation of liver enzymes, serum bilirubin, uric acid, and blood glucose may occur.

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Complete list of drug interactions

Major Interactions

Moderate Interactions

Minor Interactions




Adapted from the FDA Package Insert.