Glycerin

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Glycerin
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Glycerin is a Laxative that is FDA approved for the treatment of constipation. Common adverse reactions include rectal discomfort or a burning sensation, diarrhea.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

  • relieves occasional constipation (irregularity)
  • generally produces bowel movement in 1/4 to 1 hour

Directions

Glycerin dosage.png

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Glycerin in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Glycerin in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

  • relieves occasional constipation (irregularity)
  • generally produces bowel movement in 1/4 to 1 hour

Directions

Glycerin dosage.png

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Glycerin in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Glycerin in pediatric patients.

Contraindications

There is limited information regarding Glycerin Contraindications in the drug label.

Warnings

  • For rectal use only
  • Do not use laxative products for longer than 1 week unless directed by a doctor
  • Ask a doctor before use if you have
  • When using this product you may have rectal discomfort or a burning sensation
  • Stop use and ask a doctor if you have rectal bleeding or fail to have a bowel movement after use of a laxative. These could be signs of a serious condition.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Glycerin in the drug label.

Postmarketing Experience

Drug Interactions

There is limited information regarding Glycerin Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • IF PREGNANT OR BREAST FEEDING
  • ask a health professional before use.


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Glycerin in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Glycerin during labor and delivery.

Nursing Mothers

  • IF PREGNANT OR BREAST FEEDING
  • ask a health professional before use.

Pediatric Use

There is no FDA guidance on the use of Glycerin with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Glycerin with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Glycerin with respect to specific gender populations.

Race

There is no FDA guidance on the use of Glycerin with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Glycerin in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Glycerin in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Glycerin in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Glycerin in patients who are immunocompromised.

Administration and Monitoring

Administration

Monitoring

There is limited information regarding Monitoring of Glycerin in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Glycerin in the drug label.

Overdosage

  • If swallowed, get medical help or contact a Poison Control Center right away.

Pharmacology

Template:Chembox E numberTemplate:Chembox SolubilityInWaterTemplate:Chembox NIOSH (set)
Glycerol
IUPAC name propane-1,2,3-triol
Other names glycerin
glycerine
propanetriol
1,2,3-trihydroxypropane
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
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KEGG
UNII
Properties
C3H8O3
Molar mass 92.09 g·mol−1
Appearance colorless liquid
hygroscopic
Odor odorless
Density 1.261 g/cm3
Melting point
Boiling point
Vapor pressure 0.003 mmHg (50°C)[1]
Refractive index (nD) 1.4746
Viscosity 1.412 Pa·s[2]
Hazards
Flash point {{{value}}}
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Mechanism of Action

Structure

  • ACTIVE INGREDIENT (IN EACH SUPPOSITORY)
  • Glycerin, USP 2.1 grams
  • INACTIVE INGREDIENT
  • purified water, sodium hydroxide, stearic acid

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Glycerin in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Glycerin in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Glycerin in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Glycerin in the drug label.

How Supplied

There is limited information regarding Glycerin How Supplied in the drug label.

Storage

There is limited information regarding Glycerin Storage in the drug label.

Images

Drug Images

Package and Label Display Panel

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

This image is provided by the National Library of Medicine.

Ingredients and Appearance

This image is provided by the National Library of Medicine.

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Glycerin in the drug label.

Precautions with Alcohol

  • Alcohol-Glycerin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is limited information regarding the look alike drug names.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. 1.0 1.1 1.2 1.3 1.4 NIOSH Pocket Guide to Chemical Hazards 0302
  2. Template:Cite doi
  3. Lide, D. R., ed. (1994). CRC Handbook of Data on Organic Compounds (3rd ed.). Boca Raton, FL: CRC Press. p. 4386.
  4. "Glycerin suppository".

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