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Benadryl is a brand name that Johnson & Johnson (acquired fall 2006) and Pfizer use for several different allergy medicines.

  • In the U.S., Benadryl is diphenhydramine, a first generation antihistamine. It is also formulated in combination with other active ingredients and sold under variations of the Benadryl name.
  • In the U.K., Benadryl Allergy Relief is acrivastine, a second generation antihistamine.
  • In the U.K., Benadryl Once a Day is cetirizine, a second generation antihistamine.


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