Methdilazine

Methdilazine

Clinical data
AHFS/Drugs.com	Monograph
ATC code	R06AD04 (WHO)
Identifiers
IUPAC name 10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine
CAS Number	1982-37-2 Y
PubChem CID	14677
DrugBank	DB00902 Y
ChemSpider	14009 Y
UNII	4Q13LY9Z8X
KEGG	D04979 Y
ChEMBL	ChEMBL1200959 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C18H20N2S
Molar mass	296.431 g/mol
3D model (JSmol)	Interactive image
SMILES S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
InChI InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 Y Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

WikiDoc Resources for Methdilazine
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Evidence Based Medicine
Cochrane Collaboration on Methdilazine Bandolier on Methdilazine TRIP on Methdilazine
Clinical Trials
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US National Guidelines Clearinghouse on Methdilazine NICE Guidance on Methdilazine NHS PRODIGY Guidance FDA on Methdilazine CDC on Methdilazine
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Methdilazine in the news Be alerted to news on Methdilazine News trends on Methdilazine
Commentary
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Definitions
Definitions of Methdilazine
Patient Resources / Community
Patient resources on Methdilazine Discussion groups on Methdilazine Patient Handouts on Methdilazine Directions to Hospitals Treating Methdilazine Risk calculators and risk factors for Methdilazine
Healthcare Provider Resources
Symptoms of Methdilazine Causes & Risk Factors for Methdilazine Diagnostic studies for Methdilazine Treatment of Methdilazine
Continuing Medical Education (CME)
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International
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Business
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

See also

• Phenothiazine

References

• Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002. PMID 15782943.CS1 maint: Multiple names: authors list (link)
• Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83. PMID 9700532.CS1 maint: Multiple names: authors list (link)
• Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.CS1 maint: Multiple names: authors list (link)

The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.