CD120: Difference between revisions

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[[Image:TNF signaling.jpg|thumb|350px|Signaling pathway of [[Tumor necrosis factor-alpha|TNF]]-R1. Dashed grey lines represent multiple steps]]
{{infobox protein
{{protein
| Name = [[TNFRSF1A|tumor necrosis factor receptor superfamily, member 1A]]
| Name = [[TNFRSF1A|tumor necrosis factor receptor superfamily, member 1A]]
| caption =  
| caption =  
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| LocusSupplementaryData =  
| LocusSupplementaryData =  
}}
}}
{{protein
{{infobox protein
| Name = [[TNFRSF1B|tumor necrosis factor receptor superfamily, member 1B]]
| Name = [[TNFRSF1B|tumor necrosis factor receptor superfamily, member 1B]]
| caption =
| caption =
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'''CD120''' ('''C'''luster of '''D'''ifferentiation 120), also known as the tumor necrosis factor receptor (TNFR).  This protein is a member of the [[tumor necrosis factor receptor]] superfamily.<ref name="pmid11239407">{{cite journal | author = Locksley RM, Killeen N, Lenardo MJ | title = The TNF and TNF receptor superfamilies: integrating mammalian biology | journal = Cell | volume = 104 | issue = 4 | pages = 487–501 | year = 2001 | pmid = 11239407 | doi = 10.1016/S0092-8674(01)00237-9 | issn = }}</ref><ref name="pmid15819693">{{cite journal | author = Hehlgans T, Pfeffer K | title = The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games | journal = Immunology | volume = 115 | issue = 1 | pages = 1–20 | year = 2005 | pmid = 15819693 | doi = 10.1111/j.1365-2567.2005.02143.x | issn = }}</ref>
'''CD120''' ('''C'''luster of '''D'''ifferentiation 120) can refer to two members of the [[tumor necrosis factor receptor]] superfamily: [[tumor necrosis factor receptor 1]] (TNFR1) and [[tumor necrosis factor receptor 2]] (TNFR2).<ref name="pmid11239407">{{cite journal | vauthors = Locksley RM, Killeen N, Lenardo MJ | title = The TNF and TNF receptor superfamilies: integrating mammalian biology | journal = Cell | volume = 104 | issue = 4 | pages = 487–501 | year = 2001 | pmid = 11239407 | doi = 10.1016/S0092-8674(01)00237-9 }}</ref><ref name="pmid15819693">{{cite journal | vauthors = Hehlgans T, Pfeffer K | title = The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games | journal = Immunology | volume = 115 | issue = 1 | pages = 1–20 | year = 2005 | pmid = 15819693 | doi = 10.1111/j.1365-2567.2005.02143.x | pmc = 1782125 }}</ref>


== Receptor subtypes ==
== Receptor subtypes ==
There are two variants of the receptor, each encoded by a separate gene:
There are two variants of the receptor, each encoded by a separate gene:


* CD120a - TNFR1 - [[TNFRSF1A]]
* CD120a - TNFR1 - TNFR superfamily member 1A
* CD120b - TNFR2 - [[TNFRSF1B]]
* CD120b - TNFR2 - TNFR superfamily member 1B
 
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,<ref name="pmid18825372">{{cite journal | vauthors = Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW | title = The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior | journal = Psychopharmacology | volume = 201 | issue = 4 | pages = 549–56 |date=January 2009 | pmid = 18825372 | pmc = 2711641 | doi = 10.1007/s00213-008-1331-4 | url = | issn = }}</ref> and is involved in neurotoxic processes.<ref name="pmid18925972">{{cite journal | vauthors = McCoy MK, Tansey MG | title = TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease | journal = J Neuroinflammation | volume = 5 | issue = 1| pages = 45 | year = 2008 | pmid = 18925972 | pmc = 2577641 | doi = 10.1186/1742-2094-5-45 | url = | issn = }}</ref> Elevated levels of TNFR1 has been found in severe mental disorders.<ref name="pmid19839997">{{cite journal | vauthors = Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA | title = Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor | journal = Bipolar Disord | volume = 11 | issue = 7 | pages = 726–34 |date=November 2009 | pmid = 19839997 | doi = 10.1111/j.1399-5618.2009.00757.x | url = | issn = }}</ref>
 
== Signaling pathway ==
[[Image:TNF signaling.jpg|thumb|left|350px|Signaling pathway of [[Tumor necrosis factor-alpha|TNF]]-R1. Dashed grey lines represent multiple steps]]
{{Clear}}


== See also ==
== See also ==
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== References ==
== References ==
{{reflist|2}}
{{reflist}}


==External links==
==External links==
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* {{MeshName|CD120b+Antigen}}
* {{MeshName|CD120b+Antigen}}


{{membrane-protein-stub}}
{{clusters of differentiation}}
{{clusters of differentiation}}
{{Tumor necrosis factor receptor superfamily}}
{{Cytokine receptors}}
{{WikiDoc Sources}}
{{Cytokine receptor modulators}}

Latest revision as of 04:03, 27 August 2017

tumor necrosis factor receptor superfamily, member 1A
Identifiers
SymbolTNFRSF1A
Alt. symbolsCD120a, TNFR1
Entrez7132
HUGO11916
OMIM191190
RefSeqNM_001065
UniProtP19438
Other data
LocusChr. 12 p13.2
tumor necrosis factor receptor superfamily, member 1B
Identifiers
SymbolTNFRSF1B
Alt. symbolsCD120a, TNFR2
Entrez7133
HUGO11917
OMIM191191
RefSeqNM_001066
UniProtP20333
Other data
LocusChr. 1 p36.22

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathway

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

See also

References

  1. ↑ Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
  2. ↑ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
  3. ↑ Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology. 201 (4): 549–56. doi:10.1007/s00213-008-1331-4. PMC 2711641. PMID 18825372.
  4. ↑ McCoy MK, Tansey MG (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation. 5 (1): 45. doi:10.1186/1742-2094-5-45. PMC 2577641. PMID 18925972.
  5. ↑ Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord. 11 (7): 726–34. doi:10.1111/j.1399-5618.2009.00757.x. PMID 19839997.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=CD120&oldid=1410583"