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Tumor necrosis factor receptor superfamily, member 10a
Symbols TNFRSF10A ; APO2; CD261; DR4; MGC9365; TRAILR-1; TRAILR1
External IDs Template:OMIM5 Template:MGI HomoloGene48245
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 10a, also known as TNFRSF10A, is a human gene.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[1]


  1. "Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a".

Further reading

  • Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/ PMID 15538968.
  • Fleury S, Thibodeau J, Croteau G; et al. (1995). "HLA-DR polymorphism affects the interaction with CD4". J. Exp. Med. 182 (3): 733–41. PMID 7650480.
  • Pan G, O'Rourke K, Chinnaiyan AM; et al. (1997). "The receptor for the cytotoxic ligand TRAIL". Science. 276 (5309): 111–3. PMID 9082980.
  • Walczak H, Degli-Esposti MA, Johnson RS; et al. (1997). "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL". EMBO J. 16 (17): 5386–97. doi:10.1093/emboj/16.17.5386. PMID 9311998.
  • MacFarlane M, Ahmad M, Srinivasula SM; et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. 272 (41): 25417–20. PMID 9325248.
  • Schneider P, Bodmer JL, Thome M; et al. (1997). "Characterization of two receptors for TRAIL". FEBS Lett. 416 (3): 329–34. PMID 9373179.
  • Marsters SA, Sheridan JP, Pitti RM; et al. (1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr. Biol. 7 (12): 1003–6. PMID 9382840.
  • Chaudhary PM, Eby M, Jasmin A; et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity. 7 (6): 821–30. PMID 9430227.
  • Schneider P, Thome M, Burns K; et al. (1998). "TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB". Immunity. 7 (6): 831–6. PMID 9430228.
  • Diab BY, Lambert NC, L'Faqihi FE; et al. (1999). "Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis". Immunogenetics. 49 (1): 36–44. PMID 9811967.
  • Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–32. PMID 10400625.
  • Hymowitz SG, Christinger HW, Fuh G; et al. (1999). "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5". Mol. Cell. 4 (4): 563–71. PMID 10549288.
  • Gibson SB, Oyer R, Spalding AC; et al. (2000). "Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL". Mol. Cell. Biol. 20 (1): 205–12. PMID 10594023.
  • Kuang AA, Diehl GE, Zhang J, Winoto A (2000). "FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts". J. Biol. Chem. 275 (33): 25065–8. doi:10.1074/jbc.C000284200. PMID 10862756.
  • Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. Immunol. 2 (6): 493–500. doi:10.1038/88684. PMID 11376335.
  • Trauzold A, Wermann H, Arlt A; et al. (2001). "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells". Oncogene. 20 (31): 4258–69. doi:10.1038/sj.onc.1204559. PMID 11464292.
  • Dörr J, Bechmann I, Waiczies S; et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. Neurosci. 22 (4): RC209. PMID 11844843.
  • Koyama S, Koike N, Adachi S (2002). "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor". J. Cancer Res. Clin. Oncol. 128 (2): 73–9. doi:10.1007/s004320100292. PMID 11862476.
  • Guan B, Yue P, Lotan R, Sun SY (2002). "Evidence that the human death receptor 4 is regulated by activator protein 1". Oncogene. 21 (20): 3121–9. doi:10.1038/sj.onc.1205430. PMID 12082627.
  • Söderström TS, Poukkula M, Holmström TH; et al. (2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8". J. Immunol. 169 (6): 2851–60. PMID 12218097.

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