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Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
Symbols PVRL1 ; PRR1; CD111; CLPED1; ED4; HIgR; HVEC; MGC142031; MGC16207; OFC7; PRR; PVRR; PVRR1; SK-12; nectin-1
External IDs Template:OMIM5 Template:MGI HomoloGene2138
RNA expression pattern
File:PBB GE PVRL1 208455 at tn.png
File:PBB GE PVRL1 211846 s at tn.png
File:PBB GE PVRL1 211845 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) and CD111 (Cluster of Differentiation 111), also known as PVRL1, is a human gene.[1]

See also


  1. "Entrez Gene: PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)".

Further reading

  • Bustos T, Simosa V, Pinto-Cisternas J; et al. (1992). "Autosomal recessive ectodermal dysplasia: I. An undescribed dysplasia/malformation syndrome". Am. J. Med. Genet. 41 (4): 398–404. doi:10.1002/ajmg.1320410403. PMID 1776626.
  • Lopez M, Eberlé F, Mattei MG; et al. (1995). "Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene". Gene. 155 (2): 261–5. PMID 7721102.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
  • Geraghty RJ, Krummenacher C, Cohen GH; et al. (1998). "Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor". Science. 280 (5369): 1618–20. PMID 9616127.
  • Suzuki K, Bustos T, Spritz RA (1998). "Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia (ED4) to 11q23". Am. J. Hum. Genet. 63 (4): 1102–7. PMID 9758630.
  • Cocchi F, Menotti L, Mirandola P; et al. (1998). "The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells". J. Virol. 72 (12): 9992–10002. PMID 9811737.
  • Cocchi F, Lopez M, Menotti L; et al. (1999). "The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D.". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15700–5. PMID 9861033.
  • Takahashi K, Nakanishi H, Miyahara M; et al. (1999). "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein". J. Cell Biol. 145 (3): 539–49. PMID 10225955.
  • Miyahara M, Nakanishi H, Takahashi K; et al. (2000). "Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction". J. Biol. Chem. 275 (1): 613–8. PMID 10617658.
  • Suzuki K, Hu D, Bustos T; et al. (2000). "Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia". Nat. Genet. 25 (4): 427–30. doi:10.1038/78119. PMID 10932188.
  • Lopez M, Cocchi F, Avitabile E; et al. (2001). "Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or PRR1-HIgR-HveC) modulates positively and negatively susceptibility to HSV infection". J. Virol. 75 (12): 5684–91. doi:10.1128/JVI.75.12.5684-5691.2001. PMID 11356977.
  • Sözen MA, Suzuki K, Tolarova MM; et al. (2001). "Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela". Nat. Genet. 29 (2): 141–2. doi:10.1038/ng740. PMID 11559849.
  • Struyf F, Posavad CM, Keyaerts E; et al. (2002). "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". J. Infect. Dis. 185 (1): 36–44. PMID 11756979.
  • Fabre S, Reymond N, Cocchi F; et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
  • Yoon M, Spear PG (2002). "Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry". J. Virol. 76 (14): 7203–8. PMID 12072519.
  • Struyf F, Martinez WM, Spear PG (2002). "Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions". J. Virol. 76 (24): 12940–50. PMID 12438620.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Takekuni K, Ikeda W, Fujito T; et al. (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
  • Krummenacher C, Baribaud I, Eisenberg RJ, Cohen GH (2003). "Cellular localization of nectin-1 and glycoprotein D during herpes simplex virus infection". J. Virol. 77 (16): 8985–99. PMID 12885915.
  • Bender FC, Whitbeck JC, Ponce de Leon M; et al. (2003). "Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry". J. Virol. 77 (17): 9542–52. PMID 12915568.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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