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Tumor necrosis factor receptor superfamily, member 17
File:PBB Protein TNFRSF17 image.jpg
PDB rendering based on 1oqd.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Symbols TNFRSF17 ; BCM; BCMA; CD269
External IDs Template:OMIM5 Template:MGI HomoloGene920
RNA expression pattern
File:PBB GE TNFRSF17 206641 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 17, also known as TNFRSF17, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[1]


  1. 1.0 1.1 "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17".

Further reading

  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
  • Laâbi Y, Gras MP, Carbonnel F; et al. (1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". EMBO J. 11 (11): 3897–904. PMID 1396583.
  • Laabi Y, Gras MP, Brouet JC; et al. (1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Res. 22 (7): 1147–54. PMID 8165126.
  • Gras MP, Laâbi Y, Linares-Cruz G; et al. (1996). "BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes". Int. Immunol. 7 (7): 1093–106. PMID 8527407.
  • Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  • Gross JA, Johnston J, Mudri S; et al. (2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease". Nature. 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128.
  • Hatzoglou A, Roussel J, Bourgeade MF; et al. (2000). "TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase". J. Immunol. 165 (3): 1322–30. PMID 10903733.
  • Shu HB, Johnson H (2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9156–61. doi:10.1073/pnas.160213497. PMID 10908663.
  • Yu G, Boone T, Delaney J; et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.
  • Kawasaki A, Tsuchiya N, Fukazawa T; et al. (2001). "Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis". Genes Immun. 2 (5): 276–9. doi:10.1038/sj.gene.6363770. PMID 11528522.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Novak AJ, Darce JR, Arendt BK; et al. (2004). "Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival". Blood. 103 (2): 689–94. doi:10.1182/blood-2003-06-2043. PMID 14512299.
  • Hymowitz SG, Patel DR, Wallweber HJ; et al. (2005). "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding". J. Biol. Chem. 280 (8): 7218–27. doi:10.1074/jbc.M411714200. PMID 15542592.
  • Bellucci R, Alyea EP, Chiaretti S; et al. (2005). "Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor". Blood. 105 (10): 3945–50. doi:10.1182/blood-2004-11-4463. PMID 15692072.
  • Hendriks J, Planelles L, de Jong-Odding J; et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369.
  • Chiu A, Xu W, He B; et al. (2007). "Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL". Blood. 109 (2): 729–39. doi:10.1182/blood-2006-04-015958. PMID 16960154.
  • Smirnova AS, Andrade-Oliveira V, Gerbase-Delima M. "Identification of new splice variants of the genes BAFF and BCMA". 45 (4): 1179–1183. doi:10.1016/j.molimm.2007.07.028. PMID 17825416.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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