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Tumor necrosis factor receptor superfamily, member 13C
File:PBB Protein TNFRSF13C image.jpg
PDB rendering based on 1oqe.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Symbols TNFRSF13C ; BAFF-R; BAFFR; CD268; MGC138235
External IDs Template:OMIM5 Template:MGI HomoloGene49897
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 13C, also known as TNFRSF13C, is a human gene.[1]

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.[1]


  1. 1.0 1.1 "Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C".

Further reading

  • Laâbi Y, Egle A, Strasser A (2002). "TNF cytokine family: more BAFF-ling complexities". Curr. Biol. 11 (24): R1013–6. PMID 11747837.
  • Defrance T, Casamayor-Pallejà M, Krammer PH (2003). "The life and death of a B cell". Adv. Cancer Res. 86: 195–225. PMID 12374279.
  • Ambrose CM (2003). "BAFF-R". J. Biol. Regul. Homeost. Agents. 16 (3): 211–3. PMID 12456020.
  • Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
  • Kalled SL (2007). "Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production". Semin. Immunol. 18 (5): 290–6. doi:10.1016/j.smim.2006.06.002. PMID 16931038.
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
  • Schneider P, MacKay F, Steiner V; et al. (1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth". J. Exp. Med. 189 (11): 1747–56. PMID 10359578.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Thompson JS, Bixler SA, Qian F; et al. (2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science. 293 (5537): 2108–11. doi:10.1126/science.1061965. PMID 11509692.
  • Yan M, Brady JR, Chan B; et al. (2002). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency". Curr. Biol. 11 (19): 1547–52. PMID 11591325.
  • Rolink AG, Melchers F (2002). "BAFFled B cells survive and thrive: roles of BAFF in B-cell development". Curr. Opin. Immunol. 14 (2): 266–75. PMID 11869903.
  • Xu LG, Shu HB (2003). "TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production". J. Immunol. 169 (12): 6883–9. PMID 12471121.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Kim HM, Yu KS, Lee ME; et al. (2003). "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation". Nat. Struct. Biol. 10 (5): 342–8. doi:10.1038/nsb925. PMID 12715002.
  • Liu Y, Hong X, Kappler J; et al. (2003). "Ligand-receptor binding revealed by the TNF family member TALL-1". Nature. 423 (6935): 49–56. doi:10.1038/nature01543. PMID 12721620.
  • Gordon NC, Pan B, Hymowitz SG; et al. (2003). "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site". Biochemistry. 42 (20): 5977–83. doi:10.1021/bi034017g. PMID 12755599.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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