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Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
File:PBB Protein TNFRSF14 image.jpg
PDB rendering based on 1jma.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
External IDs Template:OMIM5 Template:MGI HomoloGene2833
RNA expression pattern
File:PBB GE TNFRSF14 209354 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator), also known as TNFRSF14, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.[1]


  1. 1.0 1.1 "Entrez Gene: TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)".

Further reading

  • Montgomery RI, Warner MS, Lum BJ, Spear PG (1996). "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family". Cell. 87 (3): 427–36. PMID 8898196.
  • Hsu H, Solovyev I, Colombero A; et al. (1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. 272 (21): 13471–4. PMID 9153189.
  • Marsters SA, Ayres TM, Skubatch M; et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. 272 (22): 14029–32. PMID 9162022.
  • Kwon BS, Tan KB, Ni J; et al. (1997). "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation". J. Biol. Chem. 272 (22): 14272–6. PMID 9162061.
  • Mauri DN, Ebner R, Montgomery RI; et al. (1998). "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21–30. PMID 9462508.
  • Lee CH, Chinpaisal C, Wei LN (1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Mol. Cell. Biol. 18 (11): 6745–55. PMID 9774688.
  • Kelly K, Manos E, Jensen G; et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
  • Zhang J, Salcedo TW, Wan X; et al. (2001). "Modulation of T-cell responses to alloantigens by TR6/DcR3". J. Clin. Invest. 107 (11): 1459–68. PMID 11390428.
  • Franco PJ, Farooqui M, Seto E, Wei LN (2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Mol. Endocrinol. 15 (8): 1318–28. PMID 11463856.
  • Carfí A, Willis SH, Whitbeck JC; et al. (2001). "Herpes simplex virus glycoprotein D bound to the human receptor HveA". Mol. Cell. 8 (1): 169–79. PMID 11511370.
  • Bobik A, Kalinina N (2002). "Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis". Arterioscler. Thromb. Vasc. Biol. 21 (12): 1873–5. PMID 11742858.
  • Struyf F, Posavad CM, Keyaerts E; et al. (2002). "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". J. Infect. Dis. 185 (1): 36–44. PMID 11756979.
  • Carfí A, Gong H, Lou H; et al. (2002). "Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 5): 836–8. PMID 11976496.
  • Hu YC, Shyr CR, Che W; et al. (2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". J. Biol. Chem. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804.
  • Gill RM, Ni J, Hunt JS (2003). "Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes". Am. J. Pathol. 161 (6): 2011–7. PMID 12466117.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Bender FC, Whitbeck JC, Ponce de Leon M; et al. (2003). "Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry". J. Virol. 77 (17): 9542–52. PMID 12915568.
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
  • Jung HW, La SJ, Kim JY; et al. (2004). "High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases". Exp. Mol. Med. 35 (6): 501–8. PMID 14749527.
  • Krummenacher C, Baribaud F, Ponce de Leon M; et al. (2004). "Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus". Virology. 322 (2): 286–99. doi:10.1016/j.virol.2004.02.005. PMID 15110526.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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