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interleukin 22 receptor, alpha 2
Other data
LocusChr. 6 q24.1-24.2

IL22RA2 is a secreted, soluble, monomeric protein, displaying inhibitory properties on IL-22 effects in vitro. It belongs to the type II cytokine receptor family.[1]


  1. Dumoutier L, Lejeune D, Colau D, Renauld JC (2001). "Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22". J. Immunol. 166 (12): 7090–5. doi:10.4049/jimmunol.166.12.7090. PMID 11390453.

Kotenko, S V, L S Izotova, O V Mirochnitchenko, E Esterova, H Dickensheets, R P Donnelly, et S Pestka. « Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity ». Journal of Immunology 166, nᵒ. 12 (juin 15, 2001): 7096-7103.

Xu, W, S R Presnell, J Parrish-Novak, W Kindsvogel, S Jaspers, Z Chen, S R Dillon, et al. « A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist ». Proceedings of the National Academy of Sciences of the United States of America 98, nᵒ. 17 (août 14, 2001): 9511-951

Weiss, B, K Wolk, B H Grünberg, H-D Volk, W Sterry, K Asadullah, et R Sabat. « Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart ». Genes and Immunity 5, nᵒ. 5 (août 2004): 330-336. 6.

de Moura, Patricia Ribeiro, Leandra Watanabe, Lucas Bleicher, Didier Colau, Laure Dumoutier, Muriel M Lemaire, Jean-Christophe Renauld, et Igor Polikarpov. « Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22 ». FEBS Letters 583, nᵒ. 7 (avril 2, 2009): 1072-1077.

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