Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[1]
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Hildreth JE, Orentas RJ (1989). "Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation". Science. 244 (4908): 1075–8. doi:10.1126/science.2543075. PMID2543075.
Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, Shaw S (1988). "Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production". J. Immunol. 140 (5): 1401–7. PMID2894392.
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1cqp: CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION
PDB 1dgq EBI.jpg
1dgq: NMR SOLUTION STRUCTURE OF THE INSERTED DOMAIN OF HUMAN LEUKOCYTE FUNCTION ASSOCIATED ANTIGEN-1
PDB 1lfa EBI.jpg
1lfa: CD11A I-DOMAIN WITH BOUND MN++
PDB 1mjn EBI.jpg
1mjn: Crystal Structure of the intermediate affinity aL I domain mutant
PDB 1mq8 EBI.jpg
1mq8: Crystal structure of alphaL I domain in complex with ICAM-1
PDB 1mq9 EBI.jpg
1mq9: Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact
PDB 1mqa EBI.jpg
1mqa: Crystal structure of high affinity alphaL I domain in the absence of ligand or metal
PDB 1rd4 EBI.jpg
1rd4: An allosteric inhibitor of LFA-1 bound to its I-domain
PDB 1t0p EBI.png
1t0p: Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A
PDB 1xdd EBI.jpg
1xdd: X-ray structure of LFA-1 I-domain in complex with LFA703 at 2.2A resolution
PDB 1xdg EBI.jpg
1xdg: X-ray structure of LFA-1 I-domain in complex with LFA878 at 2.1A resolution
PDB 1xuo EBI.jpg
1xuo: X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution
