Endothelial protein C receptor

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{{#invoke:redirect hatnote|redirect|1}} {{#invoke:Infobox_gene|getTemplateData}} Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene.<ref name="pmid7929370">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref><ref name="pmid10518938">{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref><ref name="entrez">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> PROCR has also recently been designated CD201 (cluster of differentiation 201).

The protein encoded by this gene is a receptor for protein C that enhances its activation. Protein C is an anti-coagulant serine protease activated by the blood coagulation pathway.

Structure[edit]

EPCR protein is an N-glycosylated type I membrane protein that enhances the activation of protein C.<ref name="entrez"/> It belongs to the MHC class I/CD1 family of proteins, that is characterized by having a deep groove, that in other proteins in the family (but not in EPCR) is usually used for antigen binding.

Like the CD1 series, EPCR has a lipid in the corresponding groove. The bound lipid in EPCR is usually phosphatidylcholine, but it may be phosphatidylethanolamine, and it contributes to protein C binding, though probably not through direct contact <ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

Clinical significance[edit]

Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.<ref name="entrez"/>

The protein is also involved in Plasmodium falciparum malaria as subtypes of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family use EPCR of the host as a receptor.<ref>{{#invoke:Citation/CS1|citation |CitationClass=journal }}</ref>

References[edit]

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Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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