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Promegapoietin is a drug given during chemotherapy to increase blood cell regeneration. It is a colony-stimulating factor that stimulates megakaryocyte production.[1][2]

It functions by stimulating ligands for interleukin 3 and c-Mpl.[3]


  1. Kratz-Albers K, Scheding S, Möhle R, Bühring H, Baum C, Mc Kearn J, Büchner T, Kanz L, Brugger W (2000). "Effective ex vivo generation of megakaryocytic cells from mobilized peripheral blood CD34(+) cells with stem cell factor and promegapoietin". Exp Hematol. 28 (3): 335–46. PMID 10720698.
  3. Doshi P, Giri J, Abegg A, Favara J, Huynh M, Kahn L, Minnerly J, Pegg L, Villani-Price D, Siegel N, Staten N, Thomas J, McKearn J, Smith W (2001). "Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways". Exp Hematol. 29 (10): 1177–84. PMID 11602319.

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