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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3]


SIRPB1 has been shown to interact with TYROBP.[4][5]


  1. Kharitonenkov A; Chen Z; Sures I; Wang H; Schilling J; Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. Bibcode:1997Natur.386..181K. doi:10.1038/386181a0. PMID 9062191.
  2. van den Berg TK; van Beek EM; Buhring HJ; Colonna M; Hamaguchi M; Howard CJ; Kasuga M; Liu Y; Matozaki T; Neel BG; Parkos CA; Sano S; Vignery A; Vivier E; Wright M; Zawatzky R; Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
  3. 3.0 3.1 "Entrez Gene: SIRPB1 signal-regulatory protein beta 1".
  4. Dietrich, J; Cella M; Seiffert M; Bühring H J; Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. UNITED STATES. 164 (1): 9–12. doi:10.4049/jimmunol.164.1.9. ISSN 0022-1767. PMID 10604985.
  5. Tomasello, E; Cant C; Bühring H J; Vély F; André P; Seiffert M; Ullrich A; Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. GERMANY. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.