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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
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CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')[1] or DNAM-1 (DNAX Accessory Molecule-1)[1] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[2]

Structure and function

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set.[3]

CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[3][4] and cross-linking CD226 with antibodies causes cellular activation.[2]

See also


  1. 1.0 1.1 Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–66. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
  2. 2.0 2.1 "Entrez Gene: CD226 CD226 molecule".
  3. 3.0 3.1 Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". The Journal of Experimental Medicine. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
  4. Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". International Immunology. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383.

Further reading

  • Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH (June 1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes". Immunity. 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. PMID 8673704.
  • Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A (November 1999). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule". Immunity. 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. PMID 10591186.
  • Kojima H, Kanada H, Shimizu S, Kasama E, Shibuya K, Nakauchi H, Nagasawa T, Shibuya A (September 2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells". The Journal of Biological Chemistry. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109.
  • Shibuya K, Shirakawa J, Kameyama T, Honda S, Tahara-Hanaoka S, Miyamoto A, Onodera M, Sumida T, Nakauchi H, Miyoshi H, Shibuya A (December 2003). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation". The Journal of Experimental Medicine. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMC 2194159. PMID 14676297.
  • Reymond N, Imbert AM, Devilard E, Fabre S, Chabannon C, Xerri L, Farnarier C, Cantoni C, Bottino C, Moretta A, Dubreuil P, Lopez M (May 2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions". The Journal of Experimental Medicine. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMC 2211807. PMID 15136589.
  • Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF (August 2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large". The Journal of Biological Chemistry. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
  • Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L (March 2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)". Blood. 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.
  • Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A (February 2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis". Molecular Immunology. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.
  • Tao D, Shangwu L, Qun W, Yan L, Wei J, Junyan L, Feili G, Boquan J, Jinquan T (February 2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus". Journal of Immunology. 174 (3): 1281–90. doi:10.4049/jimmunol.174.3.1281. PMID 15661884.
  • Ma D, Sun Y, Lin D, Wang H, Dai B, Zhang X, Ouyang W, Jian J, Jia W, Xu X, Jin B (March 2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization". European Journal of Haematology. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793.
  • Storojeva I, Boulay JL, Ballabeni P, Buess M, Terracciano L, Laffer U, Mild G, Herrmann R, Rochlitz C (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer". Oncology. 68 (2–3): 246–55. doi:10.1159/000086781. PMID 16015041.
  • Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (September 2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process". The Journal of Biological Chemistry. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.
  • Jian JL, Zhu CS, Xu ZW, Ouyang WM, Ma DC, Zhang Y, Chen LJ, Yang AG, Jin BQ (September 2006). "Identification and characterization of the CD226 gene promoter". The Journal of Biological Chemistry. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814.
  • Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients". Viral Immunology. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076.
  • El-Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AW, Cook G, Feyler S, Richards SJ, Davies FE, Morgan GJ, Cook GP (September 2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells". Cancer Research. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.