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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.[1][2] It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.


  1. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (May 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. "Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

Further reading

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  • Anderson P, Caligiuri M, O'Brien C, Manley T, Ritz J, Schlossman SF (March 1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells". Proceedings of the National Academy of Sciences of the United States of America. 87 (6): 2274–8. doi:10.1073/pnas.87.6.2274. PMC 53669. PMID 2138330.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23". Immunogenetics. 32 (3): 183–6. doi:10.1007/BF02114971. PMID 2146219.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Ory PA, Clark MR, Kwoh EE, Clarkson SB, Goldstein IM (November 1989). "Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils". The Journal of Clinical Investigation. 84 (5): 1688–91. doi:10.1172/JCI114350. PMC 304039. PMID 2478590.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW (February 1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP (July 1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proceedings of the National Academy of Sciences of the United States of America. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Ravetch JV, Perussia B (August 1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". The Journal of Experimental Medicine. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Simmons D, Seed B (June 1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature. 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (July 1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599–606. PMID 7516890.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Detmers PA, Zhou D, Powell D, Lichenstein H, Kelley M, Pironkova R (August 1995). "Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase". Journal of Immunology. 155 (4): 2085–95. PMID 7543538.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Morcos M, Hänsch GM, Schönermark M, Ellwanger S, Härle M, Heckl-Ostreicher B (December 1994). "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor". Kidney International. 46 (6): 1627–34. doi:10.1038/ki.1994.462. PMID 7700021.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Schumann G, Dasgupta JD (September 1994). "Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif". International Immunology. 6 (9): 1383–92. doi:10.1093/intimm/6.9.1383. PMID 7819147.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (January 1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". The Journal of Biological Chemistry. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Altin JG, Pagler EB, Kinnear BF, Warren HS (February 1994). "Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells". Immunology and Cell Biology. 72 (1): 87–96. doi:10.1038/icb.1994.13. PMID 8157290.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Pignata C, Prasad KV, Robertson MJ, Levine H, Rudd CE, Ritz J (December 1993). "Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells". Journal of Immunology. 151 (12): 6794–800. PMID 8258691.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Cone JC, Lu Y, Trevillyan JM, Bjorndahl JM, Phillips CA (October 1993). "Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells". European Journal of Immunology. 23 (10): 2488–97. doi:10.1002/eji.1830231017. PMID 8405050.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • de Haas M, Koene HR, Kleijer M, de Vries E, Simsek S, van Tol MJ, Roos D, von dem Borne AE (April 1996). "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa". Journal of Immunology. 156 (8): 2948–55. PMID 8609432.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (November 1996). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". The Journal of Biological Chemistry. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Koene HR, Kleijer M, Algra J, Roos D, von dem Borne AE, de Haas M (August 1997). "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype". Blood. 90 (3): 1109–14. PMID 9242542.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Nourse JP, Lea R, Crooks P, Wright G, Tran H, Catalano J, Brighton T, Grigg A, Marlton P, Gandhi MK (January 2012). "The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms". Blood Coagulation & Fibrinolysis. 23 (1): 45–50. doi:10.1097/mbc.0b013e32834d7ce3. PMID 22024796.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Keane C, Nourse JP, Crooks P, Nguyen-Van D, Mutsando H, Mollee P, Lea RA, Gandhi MK (October 2012). "Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma". Internal Medicine Journal. 42 (10): 1113–9. doi:10.1111/j.1445-5994.2011.02587.x. PMID 21883784.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>