Decay accelerating factor

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CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Identifiers
SymbolCD55
Alt. symbolsDAF
Entrez1604
HUGO2665
OMIM125240
RefSeqNM_000574
UniProtP08174
Other data
LocusChr. 1 q32

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

Pathology

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.

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