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Tumor necrosis factor receptor superfamily, member 13B
File:PBB Protein TNFRSF13B image.jpg
PDB rendering based on 1xu1.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Symbols TNFRSF13B ; CD267; CVID; FLJ39942; MGC133214; MGC39952; TACI; TNFRSF14B
External IDs Template:OMIM5 Template:MGI HomoloGene49320
RNA expression pattern
File:PBB GE TNFRSF13B 207641 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 13B, also known as TNFRSF13B, is a human gene.[1]

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.[1]


  1. 1.0 1.1 "Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B".

Further reading

  • Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
  • Salzer U, Jennings S, Grimbacher B (2007). "To switch or not to switch--the opposing roles of TACI in terminal B cell differentiation". Eur. J. Immunol. 37 (1): 17–20. doi:10.1002/eji.200636914. PMID 17171762.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • von Bülow GU, Bram RJ (1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily". Science. 278 (5335): 138–41. PMID 9311921.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Gross JA, Johnston J, Mudri S; et al. (2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease". Nature. 404 (6781): 995–9. doi:10.1038/35010115. PMID 10801128.
  • Xia XZ, Treanor J, Senaldi G; et al. (2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". J. Exp. Med. 192 (1): 137–43. PMID 10880535.
  • Yan M, Marsters SA, Grewal IS; et al. (2001). "Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity". Nat. Immunol. 1 (1): 37–41. doi:10.1038/76889. PMID 10881172.
  • Marsters SA, Yan M, Pitti RM; et al. (2000). "Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI". Curr. Biol. 10 (13): 785–8. PMID 10898980.
  • von Bülow GU, Russell H, Copeland NG; et al. (2000). "Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse". Mamm. Genome. 11 (8): 628–32. PMID 10920230.
  • Wu Y, Bressette D, Carrell JA; et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
  • Yu G, Boone T, Delaney J; et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Novak AJ, Darce JR, Arendt BK; et al. (2004). "Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival". Blood. 103 (2): 689–94. doi:10.1182/blood-2003-06-2043. PMID 14512299.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hymowitz SG, Patel DR, Wallweber HJ; et al. (2005). "Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding". J. Biol. Chem. 280 (8): 7218–27. doi:10.1074/jbc.M411714200. PMID 15542592.
  • Moreaux J, Cremer FW, Reme T; et al. (2005). "The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature". Blood. 106 (3): 1021–30. doi:10.1182/blood-2004-11-4512. PMID 15827134.
  • Castigli E, Wilson SA, Garibyan L; et al. (2005). "TACI is mutant in common variable immunodeficiency and IgA deficiency". Nat. Genet. 37 (8): 829–34. doi:10.1038/ng1601. PMID 16007086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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