Granulocyte macrophage colony-stimulating factor receptor
|colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)|
|Locus||Chr. Y p11|
The granulocyte macrophage colony-stimulating factor receptor is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells..
The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor. The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.
Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family. This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway. 
- N.A. Nicola,D. Metcalf. (1985). Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol. 124:313
- B.J. McClure, T.R. Hercus, B.A. Cambareri, J.M. Woodcock, C.J. Bagley. G.J. Howlett, and A.F. Lopez (2003) Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex Blood Vol 101, No. 4
- N. Geijsena, L. Koendermana and P.J. Coffer (2001) Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine & Growth Factor Reviews Vol 12 Issue 1 Pages 19-25
- S.E. Doyle and J.C. Gasson (1998) Characterization of the Role of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Subunit in the Activation of JAK2 and STAT5 Blood Vol 92 No 3 pp 867-876
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