Jump to navigation Jump to search

Tumor necrosis factor (ligand) superfamily, member 13
Symbols TNFSF13 ; APRIL; CD256; TALL2; TRDL-1; UNQ383/PRO715; ligand
External IDs Template:OMIM5 Template:MGI HomoloGene56971
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor (ligand) superfamily, member 13, also known as TNFSF13, is a human gene.[1] TNFSF13 has also been designated CD256 (cluster of differentiation 256).

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]


  1. 1.0 1.1 "Entrez Gene: TNFSF13 tumor necrosis factor (ligand) superfamily, member 13".

Further reading

  • Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
  • Tangye SG, Bryant VL, Cuss AK, Good KL (2007). "BAFF, APRIL and human B cell disorders". Semin. Immunol. 18 (5): 305–17. doi:10.1016/j.smim.2006.04.004. PMID 16916610.
  • Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
  • Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Hahne M, Kataoka T, Schröter M; et al. (1998). "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth". J. Exp. Med. 188 (6): 1185–90. PMID 9743536.
  • Shu HB, Hu WH, Johnson H (1999). "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens". J. Leukoc. Biol. 65 (5): 680–3. PMID 10331498.
  • Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.
  • Kelly K, Manos E, Jensen G; et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
  • Wu Y, Bressette D, Carrell JA; et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
  • Yu G, Boone T, Delaney J; et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284.
  • Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock". RNA. 7 (9): 1348–61. PMID 11565755.
  • López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Rep. 2 (10): 945–51. doi:10.1093/embo-reports/kve198. PMID 11571266.
  • Stein JV, López-Fraga M, Elustondo FA; et al. (2002). "APRIL modulates B and T cell immunity". J. Clin. Invest. 109 (12): 1587–98. PMID 12070306.
  • Litinskiy MB, Nardelli B, Hilbert DM; et al. (2002). "DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL". Nat. Immunol. 3 (9): 822–9. doi:10.1038/ni829. PMID 12154359.
  • Roschke V, Sosnovtseva S, Ward CD; et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. PMID 12370363.
  • Pradet-Balade B, Medema JP, López-Fraga M; et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein". EMBO J. 21 (21): 5711–20. PMID 12411489.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:WikiDoc Sources