Interleukin 1 receptor, type I: Difference between revisions

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==Interactions==
==Interactions==
Interleukin 1 receptor, type I has been shown to [[Protein-protein interaction|interact]] with [[PIK3R1]],<ref name=pmid9360994>{{cite journal |doi=10.1074/jbc.272.46.29167 |last=Reddy |first=S A |authorlink= |author2=Huang J H |author3=Liao W S  |date=November 1997  |title=Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation |journal=J. Biol. Chem. |volume=272 |issue=46 |pages=29167–73 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9360994 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Myd88]]<ref name=pmid10854325>{{cite journal |last=Burns |first=K |authorlink= |author2=Clatworthy J |author3=Martin L |author4=Martinon F |author5=Plumpton C |author6=Maschera B |author7=Lewis A |author8=Ray K |author9=Tschopp J |author10=Volpe F  |date=June 2000  |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor |journal=Nat. Cell Biol. |volume=2 |issue=6 |pages=346–51 |publisher= |location = ENGLAND| issn = 1465-7392| pmid = 10854325 |doi = 10.1038/35014038 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9374458>{{cite journal |doi=10.1126/science.278.5343.1612 |last=Muzio |first=M |authorlink= |author2=Ni J |author3=Feng P |author4=Dixit V M  |date=November 1997  |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling |journal=[[Science (journal)|Science]] |volume=278 |issue=5343 |pages=1612–5 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9374458 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[IL1RAP]].<ref name=pmid9371760>{{cite journal |doi=10.1073/pnas.94.24.12829 |last=Huang |first=J |authorlink= |author2=Gao X |author3=Li S |author4=Cao Z  |date=November 1997  |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=24 |pages=12829–32 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9371760 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=24223 }}</ref>
Interleukin 1 receptor, type I has been shown to [[Protein-protein interaction|interact]] with [[PIK3R1]],<ref name=pmid9360994>{{cite journal |doi=10.1074/jbc.272.46.29167 |last=Reddy |first=S A |authorlink= |author2=Huang J H |author3=Liao W S  |date=November 1997  |title=Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation |journal=J. Biol. Chem. |volume=272 |issue=46 |pages=29167–73 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9360994 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Myd88]]<ref name=pmid10854325>{{cite journal |last=Burns |first=K |authorlink= |author2=Clatworthy J |author3=Martin L |author4=Martinon F |author5=Plumpton C |author6=Maschera B |author7=Lewis A |author8=Ray K |author9=Tschopp J |author10=Volpe F  |date=June 2000  |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor |journal=Nat. Cell Biol. |volume=2 |issue=6 |pages=346–51 |publisher= |location = ENGLAND| issn = 1465-7392| pmid = 10854325 |doi = 10.1038/35014038 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9374458>{{cite journal |doi=10.1126/science.278.5343.1612 |last=Muzio |first=M |authorlink= |author2=Ni J |author3=Feng P |author4=Dixit V M  |date=November 1997  |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling |journal=[[Science (journal)|Science]] |volume=278 |issue=5343 |pages=1612–5 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9374458 | bibcode =1997Sci...278.1612M | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[IL1RAP]].<ref name=pmid9371760>{{cite journal |doi=10.1073/pnas.94.24.12829 |last=Huang |first=J |authorlink= |author2=Gao X |author3=Li S |author4=Cao Z  |date=November 1997  |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=24 |pages=12829–32 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9371760 | bibcode =1997PNAS...9412829H | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=24223 }}</ref>


==See also==
==See also==
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*{{cite journal  |vauthors=McMahan CJ, Slack JL, Mosley B, etal |title=A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2821–32 |year= 1991 |pmid= 1833184 |doi=  | pmc=452992  }}
*{{cite journal  |vauthors=McMahan CJ, Slack JL, Mosley B, etal |title=A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2821–32 |year= 1991 |pmid= 1833184 |doi=  | pmc=452992  }}
*{{cite journal  |vauthors=Uhl J, Newton RC, Giri JG, etal |title=Identification of IL-1 receptors on human monocytes. |journal=J. Immunol. |volume=142 |issue= 5 |pages= 1576–81 |year= 1989 |pmid= 2521881 |doi=  }}
*{{cite journal  |vauthors=Uhl J, Newton RC, Giri JG, etal |title=Identification of IL-1 receptors on human monocytes. |journal=J. Immunol. |volume=142 |issue= 5 |pages= 1576–81 |year= 1989 |pmid= 2521881 |doi=  }}
*{{cite journal  |vauthors=Sims JE, Acres RB, Grubin CE, etal |title=Cloning the interleukin 1 receptor from human T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8946–50 |year= 1989 |pmid= 2530587 |doi=10.1073/pnas.86.22.8946  | pmc=298407  }}
*{{cite journal  |vauthors=Sims JE, Acres RB, Grubin CE, etal |title=Cloning the interleukin 1 receptor from human T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8946–50 |year= 1989 |pmid= 2530587 |doi=10.1073/pnas.86.22.8946  | pmc=298407  |bibcode=1989PNAS...86.8946S }}
*{{cite journal  |vauthors=Chua AO, Gubler U |title=Sequence of the cDNA for the human fibroblast type interleukin-1 receptor. |journal=Nucleic Acids Res. |volume=17 |issue= 23 |pages= 10114 |year= 1990 |pmid= 2532321 |doi=10.1093/nar/17.23.10114  | pmc=335251  }}
*{{cite journal  |vauthors=Chua AO, Gubler U |title=Sequence of the cDNA for the human fibroblast type interleukin-1 receptor. |journal=Nucleic Acids Res. |volume=17 |issue= 23 |pages= 10114 |year= 1990 |pmid= 2532321 |doi=10.1093/nar/17.23.10114  | pmc=335251  }}
*{{cite journal  |vauthors=Dower SK, Kronheim SR, Hopp TP, etal |title=The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. |journal=Nature |volume=324 |issue= 6094 |pages= 266–8 |year= 1987 |pmid= 2946959 |doi= 10.1038/324266a0 }}
*{{cite journal  |vauthors=Dower SK, Kronheim SR, Hopp TP, etal |title=The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical. |journal=Nature |volume=324 |issue= 6094 |pages= 266–8 |year= 1987 |pmid= 2946959 |doi= 10.1038/324266a0 |bibcode=1986Natur.324..266D }}
*{{cite journal  |vauthors=Rautonen N, Rautonen J, Martin NL, Wara DW |title=HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells. |journal=AIDS |volume=8 |issue= 10 |pages= 1504–6 |year= 1995 |pmid= 7818827 |doi=10.1097/00002030-199410000-00023  }}
*{{cite journal  |vauthors=Rautonen N, Rautonen J, Martin NL, Wara DW |title=HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells. |journal=AIDS |volume=8 |issue= 10 |pages= 1504–6 |year= 1995 |pmid= 7818827 |doi=10.1097/00002030-199410000-00023  }}
*{{cite journal  |vauthors=Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ |title=Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. |journal=Nature |volume=386 |issue= 6621 |pages= 190–4 |year= 1997 |pmid= 9062193 |doi= 10.1038/386190a0 }}
*{{cite journal  |vauthors=Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ |title=Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. |journal=Nature |volume=386 |issue= 6621 |pages= 190–4 |year= 1997 |pmid= 9062193 |doi= 10.1038/386190a0 |bibcode=1997Natur.386..190V }}
*{{cite journal  |vauthors=Schreuder H, Tardif C, Trump-Kallmeyer S, etal |title=A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. |journal=Nature |volume=386 |issue= 6621 |pages= 194–200 |year= 1997 |pmid= 9062194 |doi= 10.1038/386194a0 }}
*{{cite journal  |vauthors=Schreuder H, Tardif C, Trump-Kallmeyer S, etal |title=A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. |journal=Nature |volume=386 |issue= 6621 |pages= 194–200 |year= 1997 |pmid= 9062194 |doi= 10.1038/386194a0 |bibcode=1997Natur.386..194S }}
*{{cite journal  |vauthors=Rameshwar P, Poddar A, Zhu G, Gascón P |title=Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts. |journal=J. Immunol. |volume=158 |issue= 7 |pages= 3417–24 |year= 1997 |pmid= 9120302 |doi=  }}
*{{cite journal  |vauthors=Rameshwar P, Poddar A, Zhu G, Gascón P |title=Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts. |journal=J. Immunol. |volume=158 |issue= 7 |pages= 3417–24 |year= 1997 |pmid= 9120302 |doi=  }}
*{{cite journal  |vauthors=Reddy SA, Huang JH, Liao WS |title=Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29167–73 |year= 1997 |pmid= 9360994 |doi=10.1074/jbc.272.46.29167  }}
*{{cite journal  |vauthors=Reddy SA, Huang JH, Liao WS |title=Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29167–73 |year= 1997 |pmid= 9360994 |doi=10.1074/jbc.272.46.29167  }}
*{{cite journal  |vauthors=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829–32 |year= 1998 |pmid= 9371760 |doi=10.1073/pnas.94.24.12829  | pmc=24223  }}
*{{cite journal  |vauthors=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829–32 |year= 1998 |pmid= 9371760 |doi=10.1073/pnas.94.24.12829  | pmc=24223  |bibcode=1997PNAS...9412829H }}
*{{cite journal  |vauthors=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612–5 |year= 1997 |pmid= 9374458 |doi=10.1126/science.278.5343.1612  }}
*{{cite journal  |vauthors=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612–5 |year= 1997 |pmid= 9374458 |doi=10.1126/science.278.5343.1612  |bibcode=1997Sci...278.1612M }}
*{{cite journal  |vauthors=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767 }}
*{{cite journal  |vauthors=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767 }}
*{{cite journal  |vauthors=Sizemore N, Leung S, Stark GR |title=Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4798–805 |year= 1999 |pmid= 10373529 |doi=  | pmc=84278  }}
*{{cite journal  |vauthors=Sizemore N, Leung S, Stark GR |title=Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4798–805 |year= 1999 |pmid= 10373529 |doi=  | pmc=84278  }}

Latest revision as of 01:45, 24 June 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[1]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[1]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,[2] Myd88[3][4] and IL1RAP.[5]

See also

References

  1. 1.0 1.1 "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
  2. Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. UNITED STATES. 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
  3. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
  4. Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. UNITED STATES. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
  5. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.