IL1RAP

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[1][2][3]

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[3]

Interactions

IL1RAP has been shown to interact with TOLLIP[4] and Interleukin 1 receptor, type I.[5]

References

  1. Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
  2. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
  3. 3.0 3.1 "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
  4. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. ENGLAND. 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
  5. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading




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