Drug allergy causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2], Jolanta Marszalek, M.D. [3]

Overview

The types of drugs that can cause drug allergies vary. Drugs containing sulfa are common in causing drug allergy reactions. Other common drugs implicated in leading to an allergic reaction are antibiotics, insulin, and iodinated drugs.

Causes

Common Causes

When a medication causes an allergic reaction, it is called an allergen. The following is a short list of the most common drug allergens

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Effect Abatacept, Abciximab, Acebutolol, Acetazolamide, Acetylcysteine, Acyclovir, Adalimumab, Adapalene, Adenosine, Albuterol, Alendronate, Aliskiren, Allopurinol, Alteplase, Amifostine, Amiloride, Aminocaproic acid, Amiodarone, Amlodipine, Amlodipine besylate and Valsartan, Anastrozole, Antihemophilic factor, Anti-inhibitor coagulant complex, Antithrombin III, Argatroban, Aripiprazole, Armodafinil, Atazanavir, Atenolol, Atomoxetine, Atorvastatin calcium, Barbiturates, Benazepril, Bendamustine, Benoxaprofen, Betaxolol, Bevacizumab, Bisoprolol, Botulinum toxin, Brentuximab vedotin, Brimonidine, Brinzolamide, Budesonide And Formoterol Fumarate Dihydrate, Bumetanide, Buprenorphine Hydrochloride, Naloxone Hydrochloride, Cabergoline, Captopril, Carbamazepine, Carbidopa and Levodopa, Carteolol, Carvedilol, Cefdinir, Celecoxib, Cephalosporins, Cetuximab, Chlorambucil, Chlormezanone, Chlorothiazide, Chlorthalidone, Cholestyramine, Ciclosporin, Cilostazol, Ciprofloxacin and Dexamethasone, Citalopram Hydrobromide, Clindamycin, Clonidine, Clopidogrel, Coagulation factor VIIa, Codeine, Colestipol, Conivaptan, Cyclobenzaprine, Cyclophosphamide, Dabigatran, Dalteparin, Danazol, Daptomycin, Darbepoetin Alfa, Darifenacin, Dasatinib, Denosumab, Desirudin, Desvenlafaxine, Dexamethasone, Dexlansoprazole, Dexmethylphenidate, Diazoxide, Diclofenac, Diclofenamide, Dofetilide, Digoxin, Digoxin immune fab, Diltiazem, Donepezil, Dipyridamole, Disopyramide, Dobutamine, Dorzolamide, Doxycycline Hyclate, Dronedarone, Duloxetine, Dutasteride, Dutasteride and Tamsulosin hydrochloride, Efavirenz, Emtricitabine, and Tenofovir disoproxil fumarate, Ethynodiol diacetate and ethinyl estradiol, Enalapril maleate, Enoxaparin, Epoetin alfa, Eprosartan, Eptifibatide, Erlotinib, Erythropoietin, Esmolol, Esomeprazole, Eszopiclone, Etanercept, Etonogestrel and Ethinyl Estradiol Vaginal Ring, Ethacrynic acid, Ethambutol, Ethotoin, Etodolac, Etravirine, Everolimus, Exenatide, Ezetimibe, Ezetimibe And Simvastatin, Factor IX complex, Felodipine, Fenofibrate, Fenoldopam, Filgrastim, Flecainide, Fluconazole, Fluphenazine, Fluticasone, Fluticasone and Salmeterol, Fluvastatin, Fondaparinux, Fosamprenavir, Fosinopril, Glimepiride, Glyburide and Metformin, Gold, HPV Vaccine, Hydrocodone bitartrate and Homatropine methylbromide, Ibandronic acid, Ibritumomab tiuxetan, Ibuprofen, Imiquimod, Interferon beta-1b, Ipilimumab, Insulin, Insulin glulisine, Interferon beta-1a, Ipratropium Bromide And Albuterol, Irbesartan, Isoniazid, Isotretinoin, Ketorolac tromethamine Lamotrigine, Leflunomide, Lenalidomide, levetiracetam, Levonorgestrel and Ethinyl estradiol, Linagliptin, Linagliptin and Metformin hydrochloride, Lisinopril and Hydrochlorothiazide, Losartan and Hydrochlorothiazide, Medroxyprogesterone, Mefenamic acid, Meloxicam, Mesalamine, Metformin, Methimazole, Methotrexate, Methyldopa, Methylphenidate, Metronidazole, Mirabegron, Moxifloxacin, Mupirocin, Mycophenolate, Nafarelin, Naproxen sodium, Nebivolol, Nevirapine, Nitrofurantoin, Norgestimate and Ethinyl estradiol, Norgestrel and Ethinyl estradiol, NSAIDs, Nystatin, Ofloxacin, Oxycodone, Oxytocin, Pantoprazole, Paroxetine, Pemetrexed, Penicillamine, Pentosan polysulfate, Phenacetin, Phenobarbitol, Phenylbutazone, Piroxicam, Prochlorperazine, Progesterone, Saxagliptin hydrochloride and Metformin hydrochloride, Phenytoin, Pioglitazone, Potassium chloride, Primidone, Procainamide, Quinidine, Rifabutin, Risedronate, Rosiglitazone, Rosuvastatin, Sorafenib, Streptomycin, Sulfacetamide sodium And Prednisolone acetate, Sulfasalazine, Sulfonamide, Sulfonylurea, Sumatriptan, Suramin, Tacrolimus, Tamoxifen, Terbinafine, Tetracycline, Thiabendazole, Thioacetazone, Tolterodine, Tretinoin, Triamcinolone, Valsartan, Vancomycin, Vandetanib, Varenicline, Zaleplon, Zanamivir, Zidovudine, Zolpidem, Zonisamide
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

Causes by Specific Allergic Reactions[1][2]

Cutaneous reactions Clinical features Implicated medications
Exanthems ▸ Delayed-type hypersensitivity
▸ Evolve over days after drug initiation
▸ Diffuse macules and papules
Allopurinol, Amlodipine, Amphotericin, Barbiturates, Captopril, carbamazepine, cephalosporins, chloramphenicol, Digoxin, Erythromycin, Furosemide, gentamicin, Glipizide, gold salts, Lithium, Nalidixic acid, Nitrofurantoin, Penicillins, Phenothiazines, Phenylbutazone, Phenytoin, Sulfonamides, Thiazides
Urticaria/ angioedema ▸ Often IgE mediated
▸ Onset within minutes of drug initiation
Abatacept, ACE inhibitors, Acetylcysteine, Acyclovir, Adalimumab, Albuterol, Alendronate, Aliskiren, Alteplase, Aminosalicylic acid, Amlodipine, Amlodipine and Benazepril, Anastrozole, Anti-inhibitor coagulant complex, Anticonvulsants, Antihemophilic factor, Antithrombin III, Aripiprazole, Armodafinil, Aspirin, Atomoxetine, Atropine, Beclometasone dipropionate, Benazepril, Budesonide And Formoterol Fumarate Dihydrate, Butabarbital, Captopril, Carbidopa and Levodopa, Carvedilol, Celecoxib, cephalosporins, Cetuximab, Cholestyramine, Ciclosporin, Cisplatin, Clomifene, Clonidine, Clopidogrel, Colestipol, Cyclobenzaprine, Darbepoetin Alfa, Darifenacin, Darunavir, Dasatinib, Deferasirox, Denosumab, desvenlafaxine, Dexamethasone, Dexlansoprazole, Dexmethylphenidate, Dextran, Diflunisal, Digoxin immune fab, Dofetilide, Donepezil, Dutasteride, Dutasteride and Tamsulosin hydrochloride, Enalapril maleate, Enoxaparin, Epoetin alfa, Erythropoietin, Esomeprazole, Eszopiclone, Everolimus, Exenatide, Ezetimibe, Factor IX complex, Febuxostat, Felodipine, Fesoterodine, Filgrastim, Fluoxetine, Fluphenazine, Fluticasone, Fosinopril, Frovatriptan, Gemfibrozil, Gentamicin, Glimepiride, Glipizide, Glyburide, Heparin, Hydralazine, Hydroxychloroquine, Hyoscyamine, Ibuprofen, Indomethacin, Interferon beta-1a, Ipratropium bromide, Ipratropium Bromide And Albuterol, Irbesartan, Isotretinoin, Isradipine, Lamotrigine, Levalbuterol, Levonorgestrel and Ethinyl estradiol, Levothyroxine, Linagliptin, Linagliptin and Metformin hydrochloride, Liraglutide, Lisinopril, Lisinopril and Hydrochlorothiazide, Loperamide, Losartan and Hydrochlorothiazide, Medroxyprogesterone, Minocycline hydrochloride, Moxifloxacin ophthalmic, Mupirocin, Losartan, Meloxicam, Metaxalone, Methimazole, Methocarbamol, Methylphenidate, Metoclopramide, Metolazone, Mirabegron, Modafinil, Moexipril hydrochloride, Monoclonal antibodies, Moxifloxacin, Nabumetone, Nafarelin, Naltrexone, Naproxen and esomeprazole magnesium, Nisoldipine, Nitrofurantoin, Norgestimate and Ethinyl estradiol, NSAIDs, Ofloxacin, Olodaterol, Olmesartan, Omalizumab, Opioids, Orphenadrine, Oxcarbazepine, Oxycodone, Pantoprazole, Pegfilgrastim, Penicillins, Pentamidine Isethionate, Pentoxifylline, Perindopril, Phentermine, Pramipexole, Prochlorperazine, Promethazine, Rifaximin, Saxagliptin, Saxagliptin hydrochloride and Metformin hydrochloride, Sertraline, Pitavastatin, Procainamide, Rizatriptan, Quinidine sulfate, Quinine, Ramipril, Ranolazine, Raxibacumab, Repaglinide, Risedronate, Rosuvastatin, Sitagliptin, Sulfonamides, Sumatriptan, Tenofovir, Tetracyclines, Thalidomide, Thiouracil, Ticlopidine, Tizanidine, Tocilizumab, Tolterodine, Tubocurarine, Ustekinumab, Valacyclovir, Valsartan, Vancomycin, Vardenafil, Varenicline, Velaglucerase alfa, Zaleplon, Zolmitriptan, Zolpidem
Fixed drug eruption ▸ Hyperpigmented plaques that recur at same skin or mucosal site ACE inhibitors, adalimumab, allopurinol, amlodipine, aspirin, barbiturates, benzodiazepines, carbamazepine, cephalosporins, clindamycin, co-trimoxazole, dextromethorphan, diltiazem, fluconazole, lamotrigine, lansoprazole, metronidazole, NSAIDs, paclitaxel, paracetamol, penicillin, phenolphthalein, omeprazole, quinine, salicylates, sulfonamides, terbinafine, tetracyclines, trimethoprim
Pustules ▸ Acute generalized eczematous pustulosis or acneiform rash antibiotics, calcium-channel blockers, corticosteroids, sirolimus,Fluticasone,Erlotinib
Bullous ▸ Flaccid or tense blisters Argatroban, Bendamustine, Captopril, Carbidopa and Levodopa, Dasatinib, Erlotinib, Penicillamine, Furosemide, Risedronate, Vancomycin,AbciximabWarfarin, TopiramateLinezolid,MirtazapineDapsone, Allopurinol,Captopril Captopril and Hydrochlorothiazide,Clopidogrel,Erlotinib,Fosinopril, Ibuprofen, Imatinib,Indapamide,Risedronate,Zolpidem,Dasatinib,Minoxidil,Labetalol,Phenytoin,Dalteparin,Bendamustine,Tinzaparin,Tamoxifen,clarithromycin,Atorvastatin calcium,Caduet,Ticarcillin/Clavulanate,Terbinafine,Quinine,Nevirapine,Topiramate,Perindopril,Moexipril/Hydrochlorothiazide, Naproxen sodium
Cutaneous lupus erythematosus ▸ Erythematous/scaly plaques in photodistribution Hydrochlorothiazide, calcium-channel blockers, ACEIs
Stevens-Johnson syndrome (SJS) ▸ Purpuric macules on face and trunk with <10% epidermal detachment, fever, stomatitis, ocular involvement Antibiotics, Acetazolamide, Acyclovir, Alendronate, Armodafinil, Atazanavir, Barbiturates, Bendamustine, Β-lactam antibiotics, Brinzolamide, Carbamazepine, Carvedilol, Celecoxib, Chlorpropamide, Co-trimoxazole, Darunavir, Delavirdine, Deferasirox, Diflunisal, Dorzolamide, Duloxetine, efavirenz, emtricitabine, and tenofovir disoproxil fumarate, Erlotinib, Escitalopram, Etodolac, Fenofibrate, Glimepiride, Gold, H2 Antagonists, Histamine, Hydroxychloroquine, Indapamide, Indomethacin, Isotretinoin, Ketorolac tromethamine, Lamotrigine, Leflunomide, levetiracetam,Lisinopril and Hydrochlorothiazide, Macrolides, Mefenamic acid, Meloxicam, Metolazone, Mefloquine, Methotrexate, Mexiletine, Minocycline hydrochloride, Minoxidil, Mirabegron, Modafinil, Naproxen and esomeprazole magnesium, Piroxicam, Moxifloxacin, Nitrofurantoin, NSAIDS, Ofloxacin, Olmesartan medoxomil-Hydrochlorothiazide, Oxcarbazepine, Phenothiazines, Phenytoin, Rifampicin, Rivaroxaban, Simvastatin, Sitagliptin, Spironolactone, sulfacetamide sodium and prednisolone acetate, Sulfonamides, Tadalafil, Tetracyclines, Thalidomide, Thiazides, Ticlopidine, Varenicline, Zidovudine
Toxic epidermal necrolysis (TEN) ▸ Similar to SJS but >30% epidermal detachment Acetazolamide, Acyclovir, Alendronate, Allopurinol, Armodafinil, Atazanavir, Barbiturates, Bendamustine, Brinzolamide, Carbamazepine, Celecoxib, Delavirdine, Diflunisal, Dorzolamide, Erlotinib, Escitalopram, Etodolac, Finasteride, Gold, Griseofulvin, Indapamide, Indomethacin, Isotretinoin, Ketorolac tromethamine, Lamotrigine, Leflunomide, levetiracetam, Lisinopril and Hydrochlorothiazide, Mefenamic acid, Meloxicam, Methotrexate, Metolazone, Minocycline hydrochloride, Modafinil, Moxifloxacin, Naproxen and esomeprazole magnesium, Nitrofurantoin, NSAIDs, Ofloxacin, Olmesartan Medoxomil-Hydrochlorothiazide, Oxcarbazepine, Penicillins, Phenytoin, Piroxicam, Salicylates, Sitagliptin, Spironolactone, Sulfacetamide sodium And Prednisolone acetate, sulfonamides, tetracyclines, Thalidomide
Organ-specific reactions Clinical features Implicated medications
Pulmonary ▸ Pulmonary fibrosis, hypersensitivity pneumonitis Nitrofurantoin, bleomycin, Cabergoline, Cetuximab, Desvenlafaxine, Dronedarone, Erlotinib, Hydrochlorothiazide, Methyclothiazide, Methotrexate, Amiodarone, Moxifloxacin
Hepatic ▸ Hepatitis, cholestasis Acetazolamide, Para-aminosalicylic acid, Brinzolamide, Dorzolamide, Ofloxacin, Sulfacetamide sodium And Prednisolone acetate, sulfonamides, phenothiazines
Renal ▸ Interstitial nephritis, membranous glomerulonephritis Ofloxacin, Penicillin, sulfonamides, gold, penicillamine, allopurinol
Hematologic ▸ Hemolytic anemia, thrombocytopenia, granulocytopenia

▸ Hemolytic anemia — 5-Azacytidine, Acetophenazine, Aclarubicin, Actinomycin D, Albendazole, Alemtuzumab, Aminopyrine, Amitriptyline, Amodiaquine, Anakinra, Antipyrine, Azathioprine, Bevacizumab, Bortezomib, Captopril, Carbimazole, Caspofungin, Chloramphenicol, Chlorpromazine, Ciclosporin, Cidofovir, Cilazapril, Clofarabine, Clozapine, Deferiprone, Desipramine, Docetaxel, Dothiepin, Doxorubicin, Eflornithine, Ethosuximide, Erlotinib, Ethotoin, Flucytosine, Fludarabine, Fondaparinux, Ganciclovir, Gemcitabine, Glimepiride, Glyburide, Glyburide and Metformin, Gold salts, Hydroxycarbamide, Hypersplenism, Ibritumomab tiuxetan, Idarubicin, Imatinib mesylate, Interferon alpha, Interferon beta, Irinotecan, Isoniazid, Levomepromazine, Lisinopril and Hydrochlorothiazide, Mercaptopurine, Methimazole, Mirtazapine, Mitoxantrone, Nortriptyline, Ofloxacin, Paclitaxel, Penicillamine, Pentamidine, Pentostatin, Perazine, Phenylbutazone, Phenytoin, Pipothiazine, Procainamide, Propylthiouracil, Pyrimethamine, Quinidine, Remoxipride, Riluzole, Stiripentol, Sulfasalazine, Sulphonamides, Ticlopidine, Topotecan, Trastuzumab, Trimetrexate, Valganciclovir, Zidovudine, Zileuton

▸ Thrombocytopenia — Abciximab, Aldesleukin, Amobarbital, Amrinone, Armodafinil, Capreomycin, Carboplatin, Cefotaxime, Cefotetan, Cefoxitin, Ceftizoxime, Chloramphenicol, Chlorpropamide, Ciclosporin, Cinoxacin, Claforan, Diabinese, Digoxin, Disopyramide, Enoxaparin, Eptifibatide, Erlotinib, Estrogens, Ethanol, Exna, Fondaparinux, Glyburide, Heparin, Lisinopril and Hydrochlorothiazide, Ofloxacin, Paraplatin, Phenylbutazone, Procainamide, Proleukin, Rifabutin, Secobarbital, Sulfonamides, Thiazides, Tuinal

▸ Granulocytopenia — Acetazolamide, Aripiprazole, Benzthiazide, Bortezomib, Brinzolamide, Bumetanide, Capecitabine, Captopril, Carbamazepine, Ceftazidime, Celecoxib, Chlorpropamide, Dapsone, Diabinese, Disopyramide, Dorzolamide, Enalapril maleate, Exna, Fosinopril, Fortaz, Glyburide, Lisinopril and Hydrochlorothiazide, Ofloxacin, Penicillin, quinine, Rifabutin, salicylate, Sulfacetamide sodium And Prednisolone acetate, Sulfadiazine, sulfonamides

Multiorgan reactions Clinical features Implicated medications
Anaphylaxis ▸ Urticaria, angioedema, bronchospasm, gastrointestinal symptoms, hypotension Abatacept, Abciximab, Acebutolol, Acetazolamide, Acetylcysteine, Albuterol, Aliskiren, Alteplase, Amlodipine and Benazepril, Aminocaproic acid, Anastrozole, Antihemophilic factor, Anti-inhibitor coagulant complex, Aripiprazole, Armodafinil, Atomoxetine, Beclometasone dipropionate, β-lactam antibiotics, Betaxolol, Bisoprolol, Bivalirudin, Bortezomib, Buprenorphine Hydrochloride, Naloxone Hydrochloride, monoclonal antibodies, adalimumab, Benazepril, Bendamustine, Captopril, Carteolol, Carvedilol, Celecoxib, Ciclosporin, Ciprofloxacin and Dexamethasone, Cisplatin, Clopidogrel, Cyclobenzaprine, Cyclophosphamide, Dabigatran, Dalteparin, Daptomycin, Darbepoetin Alfa, Denosumab, Desirudin, Dexamethasone, Dexlansoprazole, Dexmethylphenidate, Diflunisal, Digoxin, Digoxin immune fab, Dobutamine, Enalapril maleate, Enoxaparin, epoetin alfa, Erythropoietin, Esmolol, Esomeprazole, Eszopiclone, Etanercept, Ethambutol, Etodolac, Everolimus, Exenatide, Ezetimibe, Factor IX complex, Fenoldopam, Fluconazole, Fluoxetine, Fluphenazine, Fluticasone, Fondaparinux, Furosemide, Glimepiride, Glucagon, Heparin, HPV Vaccine, Hyoscyamine, Ibandronic acid, Infliximab, Insulin glargine, Insulin glulisine, Insulin lispro, Interferon beta-1a, Interferon beta-1b, Iopromide, Ipratropium Bromide And Albuterol, Isotretinoin, Ketorolac tromethamine, Labetalol, Levalbuterol, Lepirudin, Levonorgestrel and Ethinyl estradiol, Linagliptin, Linagliptin and Metformin hydrochloride, Lisinopril and Hydrochlorothiazide, Loperamide, Losartan and Hydrochlorothiazide, Medroxyprogesterone, Mefenamic acid, Meloxicam, Mesna, Metaxalone, Methylphenidate, Methyltestosterone, Metoclopramide, Minocycline hydrochloride, Modafinil, Moxifloxacin, Mupirocin, Nabumetone, Nadolol, Nebivolol, Nitrofurantoin, Ofatumumab, Ofloxacin, Olmesartan, Omalizumab, Ondansetron, Oxytocin, Pegloticase, Penbutolol, Pindolol, Prochlorperazine, Propranolol, Progesterone, Protamine, Rituximab, Rivaroxaban, Saxagliptin, Saxagliptin hydrochloride and Metformin hydrochloride, Solifenacin, Sumatriptan, Tinzaparin, Tocilizumab, Trastuzumab, Triamcinolone, Triamterene, Urokinase, Valganciclovir hydrochloride, Velaglucerase alfa, Zaleplon, Zanamivir, Zidovudine, Zolpidem
Systemic lupus erythematosus ▸ Arthralgia, myalgias, fever, malaise Armodafinil, Hydralazine, procainamide, isoniazid, propafenone, Levonorgestrel and Ethinyl estradiol
Vasculitis ▸ Cutaneous or visceral vasculitis Allopurinol, aspirin, β-lactam antibiotics, carbamazepine, carbimazole, co-trimoxazole, diltiazem, erythromycin, gold, G-CSF, GM-CSF, Hydralazine, interferons, methotrexate, minocycline, NSAIDs, penicillamine, propylthiouracil, retinoids, sulfasalazine, sulfonamides, thiazides, thrombolytics, Adalimumab, Amiodarone, Cefdinir, Methyldopa, Amoxapine, Moxifloxacin, Fluticasone, Acyclovir, Allopurinol, Amlodipine, Bortezomib, Captopril, Captopril and Hydrochlorothiazide, Chlorothiazide, Chlorthalidone, Clopidogrel, Delavirdine, Enalapril maleate, Filgrastim, Fosinopril, Furosemide, Hydrochlorothiazide,,Imatinib, Isotretinoin, Lisinopril, Lisinopril/Hydrochlorothiazide, Losartan, Lovastatin, Methyclothiazide, Metolazone, Ofloxacin, Pravastatin, Prazosin, Ramipril, Abatacept, Spironolactone, Spironolactone/Hydrochlorothiazide, Ticlopidine, Valsartan, Colchicine, Quinidine, Quinidine gluconate, Dronedarone, Enoxaparin, Thiazide, Fluticasone/salmeterol, Infliximab, Sitagliptin, Enalaprilat, Fluoxetine, Glyburide, Hydrochloride, Hydroflumethiazide, Polythiazide, Valaciclovir, Simvastatin, Losartan and Hydrochlorothiazide, Methylphenidate, Mirabegron, Dexlansoprazole, Sumatriptan, Bisoprolol, Rituximab, Aggrenox, Penicillin G, Norfloxacin, Isoniazid, Penicillin G procaine, Famciclovir, Cefuroxime, Rifampin isoniazid, Rifampin, Interferon alfa-2a, Amoxicillin-clavulanate potassium, Interferon alfa-2a, Pegylated interferon alfa-2a, vancomycin, Atovaquone proguanil, Terbinafine, Indinavir, Ciprofloxacin Hydrochloride, Lamivudine zidovudine, Interferon alfa-2b, Gemifloxacin mesylate, Pentamidine Isethionate, Abacavir lamivudine zidovudine, Nitrofurantoin, Zidovudine, Quinine Sulfate, Valproic acid, Divalproex, Niacin/Simvastatin, Ezetimibe/Simvastatin, Felodipine, Fosinopril/Hydrochlorothiazide, Moexipril/Hydrochlorothiazide, Quinapril/Hydrochlorothiazide, Enalapril maleate/Hydrochlorothiazide, Enalapril/Felodipine, Perindopril ,Fluvastatin, Diltiazem, Metoprolol succinate and hydrochlorothiazide, Nebivolol, Amiodarone, Olmesartan Medoxomil-Hydrochlorothiazide, Amlodipine Besylate, Divalproex, Pioglitazone/Glimepiride, Aspirin/Dipyridamole
Serum sickness ▸ Urticaria, arthralgia, fever Heterologous antibodies, infliximab, Cefdinir, Bupropion, Levothyroxine, Tetracycline hydrochloride, Antivenom, Glatiramer acetate, Antivenin,,Measles, Ticlopidine, Clopidogrel, Novobiocin, Epinephrine, Omalizumab, Rituximab, Immunosuppressive drug, Digoxin, Levothyroxine, Ciprofloxacin, Cefprozil, Cefaclor, Oxacillin, Amoxicillin, Ofloxacin, Penicillin G benzathine, Ampicillin, Ceftibuten, Cefpodoxime, Terbinafine, Gemifloxacin, Metronidazole, Cefadroxil, Doxycycline, Levofloxacin, Minocycline, Moxifloxacin, Sulfadiazine, Lincomycin, Sulfamethoxazole
Drug reaction with eosinophilia and systemic symptoms (DRESS) ▸ Cutaneous eruption, fever, eosinophilia, hepatic dysfunction, lymphadenopathy Allopurinol, anticonvulsants, Armodafinil, atazanavir, Carbamazepine, minocycline, sulfonamides, spironolactone

References

  1. Khan, David A. (2010-02). "Drug allergy". The Journal of Allergy and Clinical Immunology. 125 (2 Suppl 2): –126-137. doi:10.1016/j.jaci.2009.10.028. ISSN 1097-6825. PMID 20176256. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help)
  2. Lee, Anne (2006). Adverse drug reactions. London Chicago: Pharmaceutical Press. ISBN 0853696012.