Protamine

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protamine 1
Identifiers
Symbol PRM1
Entrez 5619
HUGO 9447
OMIM 182880
RefSeq NM_002761
UniProt P04553
Other data
Locus Chr. 16 p13.13
protamine 2
Identifiers
Symbol PRM2
Entrez 5620
HUGO 9448
OMIM 182890
RefSeq NM_002762
UniProt P04554
Other data
Locus Chr. 16 p13.13

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Protamine

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Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation and DNA stabilization.

Function

When mixed with insulin, protamines slow down the onset and increase the duration of insulin action (see NPH insulin).

Protamine sulfate is an antidote for heparin. The dose of protamine sulfate used to reverse heparin is 10 mg IV for every 1,000 Units of unfractionated heparin. Care should be exercised in the patient who has ingested NPH insulin (Neutral Protamine Hagedorn) as these patients can sustain an allergic reaction to protamine sulfate. Protamine sulfate also partially reverses enoxaparin (reverses Factor Xa inhibition by 60%).

Examples

Mice, humans, and certain fish have 2 or more different protamines, whereas the sperm of bull, boar, rat, rabbit, guinea pig, and ram have one form of protamine.

Human

The 2 human protamines are denoted PRM1 and PRM2.

External links

Cost Effectiveness of Protamine

| group5 = Clinical Trials Involving Protamine | list5 = Ongoing Trials on Protamine at Clinical Trials.govTrial results on ProtamineClinical Trials on Protamine at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Protamine | list6 = US National Guidelines Clearinghouse on ProtamineNICE Guidance on ProtamineNHS PRODIGY GuidanceFDA on ProtamineCDC on Protamine


| group7 = Textbook Information on Protamine | list7 = Books and Textbook Information on Protamine


| group8 = Pharmacology Resources on Protamine | list8 = AND (Dose)}} Dosing of ProtamineAND (drug interactions)}} Drug interactions with ProtamineAND (side effects)}} Side effects of ProtamineAND (Allergy)}} Allergic reactions to ProtamineAND (overdose)}} Overdose information on ProtamineAND (carcinogenicity)}} Carcinogenicity information on ProtamineAND (pregnancy)}} Protamine in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Protamine


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Protamine | list9 = AND (pharmacogenomics)}} Genetics of ProtamineAND (pharmacogenomics)}} Pharmacogenomics of ProtamineAND (proteomics)}} Proteomics of Protamine


| group10 = Newstories on Protamine | list10 = Protamine in the newsBe alerted to news on ProtamineNews trends on Protamine</small>


| group11 = Commentary on Protamine | list11 = Blogs on Protamine

| group12 = Patient Resources on Protamine | list12 = Patient resources on ProtamineDiscussion groups on ProtaminePatient Handouts on ProtamineDirections to Hospitals Treating ProtamineRisk calculators and risk factors for Protamine


| group13 = Healthcare Provider Resources on Protamine | list13 = Symptoms of ProtamineCauses & Risk Factors for ProtamineDiagnostic studies for ProtamineTreatment of Protamine

| group14 = Continuing Medical Education (CME) Programs on Protamine | list14 = CME Programs on Protamine

| group15 = International Resources on Protamine | list15 = Protamine en EspanolProtamine en Francais

| group16 = Business Resources on Protamine | list16 = Protamine in the MarketplacePatents on Protamine

| group17 = Informatics Resources on Protamine | list17 = List of terms related to Protamine


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