Protamine

protamine 1
Identifiers
Symbol	PRM1
Entrez	5619
HUGO	9447
OMIM	182880
RefSeq	NM_002761
UniProt	P04553
Other data
Locus	Chr. 16 p13.13

protamine 2
Identifiers
Symbol	PRM2
Entrez	5620
HUGO	9448
OMIM	182890
RefSeq	NM_002762
UniProt	P04554
Other data
Locus	Chr. 16 p13.13

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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
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Commentary
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Definitions
Definitions of Protamine
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Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation and DNA stabilization.

Function

When mixed with insulin, protamines slow down the onset and increase the duration of insulin action (see NPH insulin).

Protamine sulfate is an antidote for heparin. The dose of protamine sulfate used to reverse heparin is 10 mg IV for every 1,000 Units of unfractionated heparin. Care should be exercised in the patient who has ingested NPH insulin (Neutral Protamine Hagedorn) as these patients can sustain an allergic reaction to protamine sulfate. Protamine sulfate also partially reverses enoxaparin (reverses Factor Xa inhibition by 60%).

Examples

Mice, humans, and certain fish have 2 or more different protamines, whereas the sperm of bull, boar, rat, rabbit, guinea pig, and ram have one form of protamine.

Human

The 2 human protamines are denoted PRM1 and PRM2.

External links

• MeSH Protamines
• V03AB14

Cost Effectiveness of Protamine

| group5 = Clinical Trials Involving Protamine | list5 = Ongoing Trials on Protamine at Clinical Trials.gov • Trial results on Protamine • Clinical Trials on Protamine at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Protamine | list6 = US National Guidelines Clearinghouse on Protamine • NICE Guidance on Protamine • NHS PRODIGY Guidance • FDA on Protamine • CDC on Protamine

| group7 = Textbook Information on Protamine | list7 = Books and Textbook Information on Protamine

| group8 = Pharmacology Resources on Protamine | list8 = AND (Dose)}} Dosing of Protamine • AND (drug interactions)}} Drug interactions with Protamine • AND (side effects)}} Side effects of Protamine • AND (Allergy)}} Allergic reactions to Protamine • AND (overdose)}} Overdose information on Protamine • AND (carcinogenicity)}} Carcinogenicity information on Protamine • AND (pregnancy)}} Protamine in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Protamine •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Protamine | list9 = AND (pharmacogenomics)}} Genetics of Protamine • AND (pharmacogenomics)}} Pharmacogenomics of Protamine • AND (proteomics)}} Proteomics of Protamine

| group10 = Newstories on Protamine | list10 = Protamine in the news • Be alerted to news on Protamine • News trends on Protamine</small>

| group11 = Commentary on Protamine | list11 = Blogs on Protamine

| group12 = Patient Resources on Protamine | list12 = Patient resources on Protamine • Discussion groups on Protamine • Patient Handouts on Protamine • Directions to Hospitals Treating Protamine • Risk calculators and risk factors for Protamine

| group13 = Healthcare Provider Resources on Protamine | list13 = Symptoms of Protamine • Causes & Risk Factors for Protamine • Diagnostic studies for Protamine • Treatment of Protamine

| group14 = Continuing Medical Education (CME) Programs on Protamine | list14 = CME Programs on Protamine

| group15 = International Resources on Protamine | list15 = Protamine en Espanol • Protamine en Francais

| group16 = Business Resources on Protamine | list16 = Protamine in the Marketplace • Patents on Protamine

| group17 = Informatics Resources on Protamine | list17 = List of terms related to Protamine

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