Allopurinol
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Synonyms / Brand Names: Allopurinolum, Allopurinol Sodium, Alopurinol, 7HP, Adenock, Ailural, Allo-Puren, Allopur, Allozym, Allural, Aloprim, Aloral, Alositol, Aluline, Anoprolin, Anzief, Apo-Allopurinol, Apulonga, Apurin, Apurol, Atisuril, Bleminol, Bloxanth, Caplenal, Cellidrin, Cosuric, Dabrosin, Dabroson, Dura Al, Embarin, Epidropal, Epuric, Foligan, Geapur, Gichtex, Gotax, HPP, Hamarin, Hexanuret, Ketanrift, Ketobun-A, Ledopur, Lopurin, Lysuron, Milurit, Miniplanor, Monarch, Nektrohan, Progout, Purinol, Remid, Riball, Sigapurol, Suspendol, Takanarumin, Urbol, Uricemil, Uriprim, Uripurinol, Uritas, Urobenyl, Urolit, Urosin, Urtias, Urtias 100, Xanturat, Zyloprim, Zyloric, Allohexal
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Dosing and Administration
The dosage of Allopurinol to accomplish full control of gout and to lower serum uric acid to normal or near-normal levels varies with the severity of the disease. The average is 200 to 300 mg per day for patients with mild gout and 400 to 600 mg per day for those with moderately severe tophaceous gout. The appropriate dosage may be administered in divided doses or as a single equivalent dose with the 300 mg tablet. Dosage requirements in excess of 300 mg should be administered in divided doses. The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. To reduce the possibility of flare-up of acute gouty attacks, it is recommended that the patient start with a low dose of Allopurinol (100 mg daily) and increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg/dL or less is attained but without exceeding the maximal recommended dosage.
FDA Package Insert Resources
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FDA Package Insert Resources
Indications
Contraindications
Side Effects
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Overdose
Instructions for Administration
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Pharmacokinetics and Molecular Data
FDA on Allopurinol
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Publication Resources
Most Recent Articles on Allopurinol
Review Articles on Allopurinol
Articles on Allopurinol in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Allopurinol
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Trial Resources
Ongoing Trials with Allopurinol at Clinical Trials.gov
Trial Results with Allopurinol
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Allopurinol
Cochrane Collaboration on Allopurinol
Cost Effectiveness of Allopurinol
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Allopurinol
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International Resources
Allopurinol en Español
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The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
