Topotecan

Topotecan
Systematic (IUPAC) name
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b] quinoline-3,14(4H,12H)-dione monohydrochloride
Identifiers
CAS number	119413-54-6
ATC code	L01XX17
PubChem	6419854
DrugBank	APRD00687
Chemical data
Formula	C23H23N3O5 •HCl</sub>
Mol. mass	457.9 g/mol
Pharmacokinetic data
Bioavailability	NA
Protein binding	35%
Metabolism	Hepatic
Half life	2-3 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	D (Au, U.S.)
Legal status	℞-only (U.S.), POM (UK)
Routes	Intravenous infusion, oral

WikiDoc Resources for Topotecan
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Evidence Based Medicine
Cochrane Collaboration on Topotecan Bandolier on Topotecan TRIP on Topotecan
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Overview

Topotecan hydrochloride (Hycamtin) is a chemotherapy agent that is a topoisomerase 1 inhibitor. It is used to treat ovarian cancer and lung cancer, as well as other cancer types.

After GlaxoSmithKline received final FDA approval for Hycamtin Capsules on October 15, 2007, Topotecan is the first topoisomerase inhibitor for oral use.

Administration

IV, oral.

Side effects

• Diarrhea
• Low blood counts
• Susceptibility to infection

See also

NCI Drug Dictionary Definition of Topotecan
NCI Drug Information for Patients

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