|Systematic (IUPAC) name|
|Bioavailability||Near 100% for oral dosing|
|Metabolism||Hepatic and via erythrocytes|
|Half life||0.4 - 0.8 hours (1 - 1.6 hours for active metabolite)|
|Excretion||Mainly urine (<4% feces)|
Pentoxifylline is the International Nonproprietary Name (INN) of a drug sold by Aventis under the name Trental. Its chemical name is 1-(5-oxohexyl)-3, 7-dimethylxanthine. Pentoxifylline is a xanthine derivative.
This drug is passed into the breast milk. Animal studies have shown no evidence of teratogenicity at high doses.
Pentoxifylline improves blood flow through blood vessels and therefore helps with blood circulation in the arms and legs (e.g. intermittent claudication).
It also helps prevent strokes, can be used in managing sickle cell disease and improves blood flow to the brain.
Pentoxifylline has also been used to treat nausea and headaches in the mountains (altitude sickness).
It is also a known inhibitor of Tumor necrosis factor-alpha.
Alternate brand names
- ↑ (1996) European Pentoxifylline Multi-Infarct Dementia Study. Eur Neurol. 36(5):315-21. PMID 8864715
- ↑ Pereda J, Gómez-Cambronero L, Alberola A, Fabregat G, Cerdá M, Escobar J, Sabater L, García-de-la-Asunción J, Viña J, Sastre J. Department of Physiology, School of Medicine, University of Valencia, Valencia, Spain. Br J Pharmacol. 2006 Oct;149(4):450-5. Epub 2006 Sep 4.PMID: 16953192.
Peripheral vasodilators (C04)
|Imidazoline derivatives||Phentolamine - Tolazoline|
|Niacin and derivatives||Niacin|
|Ergot alkaloids||Ergoloid- Nicergoline|
|Other peripheral vasodilators||Phenoxybenzamine - Vincamine - Naftidrofuryl|
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