Piroxicam
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| Image:Piroxicam.svg | |
| Piroxicam
| |
| Systematic (IUPAC) name | |
| (8E)-8-[hydroxy-(pyridin-2-ylamino)methylidene]- 9-methyl-10,10-dioxo-10λ6-thia-9-azabicyclo[4.4.0] deca-1,3,5-trien-7-one | |
| Identifiers | |
| CAS number | |
| ATC code | M01 M02AA07, S01BC06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C15H13N3O4S |
| Mol. mass | 331.348 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | 4 to 10% renal |
| Half life | 30 to 86 hours |
| Excretion | 4 to 10% renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C, D if used in the third trimester or near delivery |
| Legal status | |
| Routes | ? |
Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.
Other brand names for Piroxicam include "Brexin," "Erazon," "Felden", "Feldoral," "Hotemin," "Pirox von ct," "Proponol," "Reumador," "Veral," and "Vurdon."
Mechanism of action
Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes entero-hepatic circulation.
Adverse effects
Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.[1]
Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.[citation needed]
Footnotes
Topical products for joint and muscular pain (M02) | |
|---|---|
| Anti-inflammatory preparations, non-steroids | Butylpyrazolidines: Phenylbutazone - Mofebutazone - Clofezone - Oxyphenbutazone
Propionic acid derivatives: Tolmetin - Diclofenac - Fentiazac other: Benzydamine - Etofenamate - Piroxicam - Felbinac - Bufexamac - Ketoprofen - Bendazac - Naproxen - Ibuprofen - Feprazone - Niflumic acid - Meclofenamic acid - Flurbiprofen - Suxibuzone - Indometacin - Nifenazone |
| Other | Tolazoline - Dimethyl sulfoxide |
de:Piroxicam fr:Piroxicam he:פירוקסיקאם hu:Piroxicam
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
