CCR9: Difference between revisions

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{{for|the airport in Ontario, Canada|Creemore Aerodrome}}
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{{Infobox_gene}}
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'''C-C chemokine receptor type 9''' is a [[protein]] that in humans is encoded by the ''CCR9'' [[gene]].<ref name="pmid10229797">{{cite journal | vauthors = Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G | title = Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK | journal = J Immunol | volume = 162 | issue = 10 | pages = 5671–5 |date=Jun 1999 | pmid = 10229797 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCR9 chemokine (C-C motif) receptor 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10803| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chemokine (C-C motif) receptor 9
| HGNCid = 1610
| Symbol = CCR9
| AltSymbols =; CDw199; GPR-9-6; GPR28
| OMIM = 604738
| ECnumber = 
| Homologene = 22546
| MGIid = 1341902
| GeneAtlas_image1 = PBB_GE_CCR9_207445_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10803
    | Hs_Ensembl = ENSG00000173585
    | Hs_RefseqProtein = NP_006632
    | Hs_RefseqmRNA = NM_006641
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 45903023
    | Hs_GenLoc_end = 45919671
    | Hs_Uniprot = P51686
    | Mm_EntrezGene = 12769
    | Mm_Ensembl = ENSMUSG00000029530
    | Mm_RefseqmRNA = NM_009913
    | Mm_RefseqProtein = NP_034043
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 123527137
    | Mm_GenLoc_end = 123630663
    | Mm_Uniprot = Q9WUT7
  }}
}}
'''Chemokine (C-C motif) receptor 9''', also known as '''CCR9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR9 chemokine (C-C motif) receptor 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10803| accessdate = }}</ref>


CCR9 has also recently been designated '''CDw199''' ([[cluster of differentiation]] w199).
CCR9 has also recently been designated '''CDw199''' ([[cluster of differentiation]] w199).
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| summary_text = The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CCR9 chemokine (C-C motif) receptor 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10803| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. The specific ligand of this receptor is [[CCL25]]. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in thymocyte recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CCR9 chemokine (C-C motif) receptor 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10803| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CCR9}}
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2236 | title = Chemokine Receptors: CCR9 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zaballos A, Gutiérrez J, Varona R, ''et al.'' |title=Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. |journal=J. Immunol. |volume=162 |issue= 10 |pages= 5671-5 |year= 1999 |pmid= 10229797 |doi=  }}
*{{cite journal  | vauthors=Youn BS, Kim CH, Smith FO, Broxmeyer HE |title=TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. |journal=Blood |volume=94 |issue= 7 |pages= 2533–6 |year= 1999 |pmid= 10498628 |doi=  }}
*{{cite journal  | author=Youn BS, Kim CH, Smith FO, Broxmeyer HE |title=TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. |journal=Blood |volume=94 |issue= 7 |pages= 2533-6 |year= 1999 |pmid= 10498628 |doi= }}
*{{cite journal  | vauthors=Zabel BA, Agace WW, Campbell JJ |title=Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. |journal=J. Exp. Med. |volume=190 |issue= 9 |pages= 1241–56 |year= 1999 |pmid= 10544196 |doi=10.1084/jem.190.9.1241  | pmc=2195678  |display-authors=etal}}
*{{cite journal  | author=Zabel BA, Agace WW, Campbell JJ, ''et al.'' |title=Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. |journal=J. Exp. Med. |volume=190 |issue= 9 |pages= 1241-56 |year= 1999 |pmid= 10544196 |doi= }}
*{{cite journal  | vauthors=Wurbel MA, Philippe JM, Nguyen C |title=The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. |journal=Eur. J. Immunol. |volume=30 |issue= 1 |pages= 262–71 |year= 2000 |pmid= 10602049 |doi= 10.1002/1521-4141(200001)30:1<262::AID-IMMU262>3.0.CO;2-0 |display-authors=etal}}
*{{cite journal  | author=Wurbel MA, Philippe JM, Nguyen C, ''et al.'' |title=The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. |journal=Eur. J. Immunol. |volume=30 |issue= 1 |pages= 262-71 |year= 2000 |pmid= 10602049 |doi= 10.1002/1521-4141(200001)30:1<262::AID-IMMU262>3.0.CO;2-0 }}
*{{cite journal  | vauthors=Yu CR, Peden KW, Zaitseva MB |title=CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. |journal=J. Immunol. |volume=164 |issue= 3 |pages= 1293–305 |year= 2000 |pmid= 10640743 |doi= 10.4049/jimmunol.164.3.1293|display-authors=etal}}
*{{cite journal  | author=Yu CR, Peden KW, Zaitseva MB, ''et al.'' |title=CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. |journal=J. Immunol. |volume=164 |issue= 3 |pages= 1293-305 |year= 2000 |pmid= 10640743 |doi=  }}
*{{cite journal  | vauthors=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3–4 |pages= 265–8 |year= 2000 |pmid= 10702689 |doi=10.1159/000015443 }}
*{{cite journal  | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265-8 |year= 2000 |pmid= 10702689 |doi=  }}
*{{cite journal  | vauthors=Kunkel EJ, Campbell JJ, Haraldsen G |title=Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. |journal=J. Exp. Med. |volume=192 |issue= 5 |pages= 761–8 |year= 2000 |pmid= 10974041 |doi=10.1084/jem.192.5.761  | pmc=2193265 |display-authors=etal}}
*{{cite journal  | author=Kunkel EJ, Campbell JJ, Haraldsen G, ''et al.'' |title=Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. |journal=J. Exp. Med. |volume=192 |issue= 5 |pages= 761-8 |year= 2000 |pmid= 10974041 |doi=  }}
*{{cite journal  | vauthors=Papadakis KA, Prehn J, Nelson V |title=The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. |journal=J. Immunol. |volume=165 |issue= 9 |pages= 5069–76 |year= 2000 |pmid= 11046037 |doi=  10.4049/jimmunol.165.9.5069|display-authors=etal}}
*{{cite journal  | author=Papadakis KA, Prehn J, Nelson V, ''et al.'' |title=The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. |journal=J. Immunol. |volume=165 |issue= 9 |pages= 5069-76 |year= 2000 |pmid= 11046037 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Papadakis KA, Landers C, Prehn J |title=CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. |journal=J. Immunol. |volume=171 |issue= 1 |pages= 159–65 |year= 2003 |pmid= 12816994 |doi= 10.4049/jimmunol.171.1.159|display-authors=etal}}
*{{cite journal  | author=Papadakis KA, Landers C, Prehn J, ''et al.'' |title=CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. |journal=J. Immunol. |volume=171 |issue= 1 |pages= 159-65 |year= 2003 |pmid= 12816994 |doi=  }}
*{{cite journal  | vauthors=Qiuping Z, Qun L, Chunsong H |title=Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6469–77 |year= 2003 |pmid= 14559839 |doi=  |display-authors=etal}}
*{{cite journal  | author=Qiuping Z, Qun L, Chunsong H, ''et al.'' |title=Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6469-77 |year= 2003 |pmid= 14559839 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Singh S, Singh UP, Stiles JK |title=Expression and functional role of CCR9 in prostate cancer cell migration and invasion. |journal=Clin. Cancer Res. |volume=10 |issue= 24 |pages= 8743–50 |year= 2005 |pmid= 15623660 |doi= 10.1158/1078-0432.CCR-04-0266 |display-authors=etal}}
*{{cite journal  | author=Singh S, Singh UP, Stiles JK, ''et al.'' |title=Expression and functional role of CCR9 in prostate cancer cell migration and invasion. |journal=Clin. Cancer Res. |volume=10 |issue= 24 |pages= 8743-50 |year= 2005 |pmid= 15623660 |doi= 10.1158/1078-0432.CCR-04-0266 }}
*{{cite journal  | vauthors=Babu S, Blauvelt CP, Kumaraswami V, Nutman TB |title=Chemokine receptors of T cells and of B cells in lymphatic filarial infection: a role for CCR9 in pathogenesis. |journal=J. Infect. Dis. |volume=191 |issue= 6 |pages= 1018–26 |year= 2005 |pmid= 15717282 |doi= 10.1086/427658 }}
*{{cite journal  | author=Babu S, Blauvelt CP, Kumaraswami V, Nutman TB |title=Chemokine receptors of T cells and of B cells in lymphatic filarial infection: a role for CCR9 in pathogenesis. |journal=J. Infect. Dis. |volume=191 |issue= 6 |pages= 1018-26 |year= 2005 |pmid= 15717282 |doi= 10.1086/427658 }}
*{{cite journal  | vauthors=Sen Y, Yongyi B, Yuling H |title=V alpha 24-invariant NKT cells from patients with allergic asthma express CCR9 at high frequency and induce Th2 bias of CD3+ T cells upon CD226 engagement. |journal=J. Immunol. |volume=175 |issue= 8 |pages= 4914–26 |year= 2005 |pmid= 16210593 |doi= 10.4049/jimmunol.175.8.4914|display-authors=etal}}
*{{cite journal  | author=Sen Y, Yongyi B, Yuling H, ''et al.'' |title=V alpha 24-invariant NKT cells from patients with allergic asthma express CCR9 at high frequency and induce Th2 bias of CD3+ T cells upon CD226 engagement. |journal=J. Immunol. |volume=175 |issue= 8 |pages= 4914-26 |year= 2005 |pmid= 16210593 |doi= }}
*{{cite journal  | vauthors=Nagakubo D, Jin Z, Hieshima K |title=Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax. |journal=Int. J. Cancer |volume=120 |issue= 7 |pages= 1591–7 |year= 2007 |pmid= 17205512 |doi= 10.1002/ijc.22483 |display-authors=etal}}
*{{cite journal  | author=Nagakubo D, Jin Z, Hieshima K, ''et al.'' |title=Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing Tax. |journal=Int. J. Cancer |volume=120 |issue= 7 |pages= 1591-7 |year= 2007 |pmid= 17205512 |doi= 10.1002/ijc.22483 }}
*{{cite journal  | vauthors=Olaussen RW, Karlsson MR, Lundin KE |title=Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation. |journal=Gastroenterology |volume=132 |issue= 7 |pages= 2371–82 |year= 2007 |pmid= 17570212 |doi= 10.1053/j.gastro.2007.04.023 |display-authors=etal}}
*{{cite journal  | author=Olaussen RW, Karlsson MR, Lundin KE, ''et al.'' |title=Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation. |journal=Gastroenterology |volume=132 |issue= 7 |pages= 2371-82 |year= 2007 |pmid= 17570212 |doi= 10.1053/j.gastro.2007.04.023 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{Chemokine receptors}}
{{Chemokine receptors}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Chemokine receptor modulators}}
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[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 13:06, 7 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.[1][2]

CCR9 has also recently been designated CDw199 (cluster of differentiation w199).

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in thymocyte recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.[2]

References

  1. Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G (Jun 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". J Immunol. 162 (10): 5671–5. PMID 10229797.
  2. 2.0 2.1 "Entrez Gene: CCR9 chemokine (C-C motif) receptor 9".

External links

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.